Reactome | NOX3 complex:RAC1:GTP generates superoxide from oxygen

NOX3 complex:RAC1:GTP generates superoxide from oxygen

Stable Identifier

R-HSA-5668731

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane, extracellular region

ReviewStatus

5/5

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NOX3 complex:RAC1:GTP generates superoxide from oxygen

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While NOX3:CYBA complex has constitutive NADPH oxidase activity, the presence of NCF1, NCF2 or NOXA1 and RAC1:GTP enhances the production of superoxide O2- by the NOX3:CYBA complex. When NCF1 is replaced with NOXO1, RAC1:GTP becomes dispensible for the full activation of the NOX3 complex (Ueno et al. 2005, Ueyama et al. 2006, Miyano and Sumimoto 2007, Kao et al. 2008)

Literature References

PubMed ID	Title	Journal	Year
16507994	Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases Ueyama, T, Geiszt, M, Leto, TL	Mol. Cell. Biol.	2006
15824103	The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators Ueno, N, Takeya, R, Miyano, K, Kikuchi, H, Sumimoto, H	J. Biol. Chem.	2005
18347018	Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism Kao, YY, Gianni, D, Bohl, B, Taylor, RM, Bokoch, GM	J. Biol. Chem.	2008
17583407	Role of the small GTPase Rac in p22phox-dependent NADPH oxidases Miyano, K, Sumimoto, H	Biochimie	2007