Reactome | RAC1:GTP binds NOX3 complex

RAC1:GTP binds NOX3 complex

Stable Identifier

R-HSA-5668735

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Activated RAC1 (RAC1:GTP) binds to the NADPH oxidase NOX3 complex, consisting of NOX3, CYBA (p22phox), NCF1 (p47phox) and NCF2 (p67phox) or NOXA1. RAC1 directly interacts with a conserved region of NOX3 and with tetratricopeptide repeats of NCF2 or NOXA1 (Ueyama et al. 2006, Miyano and Sumimoto 2007, Kao et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
16507994	Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases Ueyama, T, Geiszt, M, Leto, TL	Mol. Cell. Biol.	2006
18347018	Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism Kao, YY, Gianni, D, Bohl, B, Taylor, RM, Bokoch, GM	J. Biol. Chem.	2008
17583407	Role of the small GTPase Rac in p22phox-dependent NADPH oxidases Miyano, K, Sumimoto, H	Biochimie	2007