Reactome | LTBR [plasma membrane]

LTBR [plasma membrane]

Stable Identifier

R-HSA-5668750

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Tumor necrosis factor receptor superfamily member 3, TNR3_HUMAN

Locations in the PathwayBrowser for interactor UniProt:O00411 POLRMT

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External Reference Information

External Reference

UniProt:P36941 LTBR

Gene Names

LTBR, D12S370, TNFCR, TNFR3, TNFRSF3

Chain

signal peptide:1-30, chain:31-435

Reference Genes

BioGPS Gene:4055 LTBR

COSMIC (genes):LTBR LTBR

CTD Gene:4055 LTBR

dbSNP Gene:4055 LTBR

ENSEMBL:ENSG00000111321 LTBR

ENSEMBL_homo_sapiens_GENE:ENSG00000111321.11 LTBR

HGNC:6718 LTBR

KEGG Gene (Homo sapiens):4055 LTBR

Monarch:4055 LTBR

NCBI Gene:4055 LTBR

OMIM:600979 LTBR

UCSC:P36941 LTBR

Reference Transcript

Other Identifiers

11717828_a_at

11746908_a_at

1497_at

16747236

203005_PM_at

203005_at

3402445

3402446

3402447

3402448

3402449

3402451

3402452

3402455

3402456

3402458

3402463

3402464

3402466

3402467

3402468

3402469

3402470

3402471

3402472

3402473

3402474

3402476

4055

7953321

GE57554

GO:0002376

GO:0005515

GO:0005794

GO:0005886

GO:0006915

GO:0006955

GO:0007165

GO:0012501

GO:0016020

GO:0023052

GO:0030154

GO:0031625

GO:0042802

GO:0043011

GO:0043123

GO:0043226

GO:0046330

GO:0048534

GO:0048856

GO:0071260

GO:2001238

HMNXSV003012809

HMNXSV003055967

ILMN_1667476

L04270_at

PH_hs_0000145

TC12000078.hg

g4505038_3p_at

Participates

as an input of

as a component of

Inferred To

LTBR [plasma membrane] (Bos taurus)

LTBR [plasma membrane] (Canis familiaris)

LTBR [plasma membrane] (Sus scrofa)

Ghost homologue of LTBR [plasma membrane] (Xenopus tropicalis)

Ltbr [plasma membrane] (Mus musculus)

Ltbr [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001257916.1, NP_002333.1

Guide to Pharmacology - Targets

1872

OpenTargets

ENSG00000111321

GeneCards

P36941

HPA

ENSG00000111321-LTBR

Ensembl

ENST00000228918, ENSP00000228918, ENSG00000111321, ENSP00000440875, ENST00000539925

PRO

P36941

Pharos - Targets

P36941

PDB

4MXW, 1RF3

Interactors (39)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13114 TRAF3	4	TRAF3 R118W [cytosol] (R-HSA-5602321) K48polyUb-TRAF3 [cytosol] (R-HSA-936556) TRAF3 [cytosol] (R-HSA-914241) K63polyUb-TRAF3 [cytosol] (R-HSA-936402)	0.669	4
UniProt:P29846-PRO_0000037666			0.616	5
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.564	3
UniProt:Q9UI14 PRAF1			0.556	3
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.556	3
UniProt:P0DTD8 NS7B			0.547	2
UniProt:A8MTY0 ZNF724	1	ZNF724P [nucleoplasm] (R-HSA-2586597)	0.527	2
UniProt:O00411 POLRMT	1	POLRMT [mitochondrial matrix] (R-HSA-163267)	0.527	2
UniProt:Q8WTV1 THAP3			0.527	2
UniProt:O95229 ZWINT	1	ZWINT [cytosol] (R-HSA-376254)	0.527	2
UniProt:Q9H2G9 BLZF1	1	BLZF1 [Golgi membrane] (R-HSA-2422372)	0.527	2
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.527	2
UniProt:Q8IXZ2 ZC3H3			0.527	2
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.527	3
UniProt:Q9UL54 TAOK2			0.527	2
UniProt:Q9HBM1 SPC25	1	SPC25 [cytosol] (R-HSA-375307)	0.527	2
UniProt:Q567U6 CCD93			0.527	2
UniProt:Q96HA1 POM121	1	POM121 [nuclear envelope] (R-HSA-157747)	0.527	2
UniProt:Q15051 IQCB1	1	IQCB1 [cytosol] (R-HSA-5626648)	0.527	2
UniProt:Q9BT92 TCHP			0.527	2
UniProt:Q96GE4 CEP95			0.527	2
UniProt:Q9BR77 CCD77			0.527	2
UniProt:Q9H0I3 CC113			0.527	2
UniProt:O43663 PRC1	1	PRC1 [cytosol] (R-HSA-264441)	0.527	2
UniProt:P0CJ78 ZN865			0.527	2
UniProt:Q9NPF0 CD320	2	CD320 [plasma membrane] (R-HSA-2980909) CD320 E88del [plasma membrane] (R-HSA-3325560)	0.527	2
UniProt:P12755 SKI	1	SKI [nucleoplasm] (R-HSA-173473)	0.527	2
UniProt:Q9H0F6 SHARPIN	1	SHARPIN [cytosol] (R-HSA-5212666)	0.527	2
UniProt:Q13490 BIRC2	5	K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(1-372) [cytosol] (R-HSA-202913) BIRC2(373-618) [cytosol] (R-HSA-202931) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2 [cytosol] (R-HSA-50847)	0.527	3
UniProt:Q9BYM8 RBCK1	1	RBCK1 [cytosol] (R-HSA-976018)	0.527	2
UniProt:Q8N5K1 CISD2			0.527	2
UniProt:Q86XZ4 SPAS2			0.527	2
UniProt:Q96EP0 RNF31	1	RNF31 [cytosol] (R-HSA-5212660)	0.527	2
UniProt:Q96A37 RN166			0.527	2
UniProt:Q6ZUS5 CC121			0.527	2
UniProt:Q8WYA0 IFT81	2	IFT81 [cilium] (R-HSA-5617769) IFT81 [ciliary tip] (R-HSA-5625369)	0.527	2
UniProt:O43557 TNFSF14	1	TNFSF14 [plasma membrane] (R-HSA-5667149)	0.524	3
UniProt:P36941 LTBR	1	LTBR [plasma membrane] (R-HSA-5668750)	0.508	2
UniProt:Q15326 ZMY11			0.508	5

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