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LTBR [plasma membrane]
Stable Identifier
R-HSA-5668750
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Tumor necrosis factor receptor superfamily member 3, TNR3_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q9H0F6 SHARPIN
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Homo sapiens)
2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Homo sapiens)
LTBR [plasma membrane] (Homo sapiens)
LA,TNFSF14 binds LTBR (Homo sapiens)
LTBR [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P36941 LTBR
Gene Names
LTBR, D12S370, TNFCR, TNFR3, TNFRSF3
Chain
signal peptide:1-30, chain:31-435
Reference Genes
BioGPS Gene:4055 LTBR
COSMIC (genes):LTBR LTBR
CTD Gene:4055 LTBR
dbSNP Gene:4055 LTBR
ENSEMBL:ENSG00000111321 LTBR
HGNC:6718 LTBR
KEGG:hsa:4055 LTBR
Monarch:4055 LTBR
NCBI Gene:4055 LTBR
OMIM:600979 LTBR
UCSC:P36941 LTBR
Reference Transcript
RefSeq:NM_001270987.1 LTBR
RefSeq:NM_002342.2 LTBR
Other Identifiers
11717828_a_at
11746908_a_at
1497_at
1559458_PM_at
1559458_at
16747236
203005_PM_at
203005_at
243400_PM_x_at
243400_x_at
3402445
3402446
3402447
3402448
3402449
3402451
3402452
3402453
3402454
3402455
3402456
3402457
3402458
3402459
3402460
3402461
3402462
3402463
3402464
3402465
3402466
3402467
3402468
3402469
3402470
3402471
3402472
3402473
3402474
3402476
3402478
35478_at
4055
67446_i_at
7953321
A_14_P117661
GE57554
GO:0002376
GO:0005515
GO:0005794
GO:0005886
GO:0006915
GO:0006955
GO:0007165
GO:0012501
GO:0016020
GO:0030154
GO:0031625
GO:0042802
GO:0043011
GO:0043123
GO:0043226
GO:0046330
GO:0048534
GO:0048856
GO:0071260
GO:2001238
HMNXSV003012809
HMNXSV003055967
Hs.185680.0.A1_3p_at
Hs.185680.0.A1_3p_x_at
Hs2.117847.1.S1_3p_at
ILMN_1667476
L04270_at
PH_hs_0000145
TC12000078.hg
g4505038_3p_at
Participates
as an input of
2xLTBR binds LTBR:lymphotoxin,TNFSF14 trimer (Homo sapiens)
LA,TNFSF14 binds LTBR (Homo sapiens)
as a component of
3xLTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
LTBR:lymphotoxin,TNFSF14 trimer [plasma membrane] (Homo sapiens)
Inferred To
LTBR [plasma membrane]
(Bos taurus)
LTBR [plasma membrane]
(Canis familiaris)
LTBR [plasma membrane]
(Sus scrofa)
Ghost homologue of LTBR [plasma membrane]
(Xenopus tropicalis)
Ltbr [plasma membrane]
(Mus musculus)
Ltbr [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_002333.1
,
NP_001257916.1
Guide to Pharmacology - Targets
1872
OpenTargets
ENSG00000111321
ENSEMBL
ENST00000539925
,
ENSP00000228918
,
ENST00000228918
,
ENSP00000440875
HPA
ENSG00000111321-LTBR
PRO
P36941
Pharos - Targets
P36941
GlyGen
P36941
PDB
1RF3
,
4MXW
Interactors (39)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q12933 TRAF2
5
TRAF2 [cytosol]
(R-HSA-66370)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
0.669
4
UniProt:Q13114 TRAF3
4
K63polyUb-TRAF3 [cytosol]
(R-HSA-936402)
TRAF3 [cytosol]
(R-HSA-914241)
K48polyUb-TRAF3 [cytosol]
(R-HSA-936556)
TRAF3 R118W [cytosol]
(R-HSA-5602321)
0.669
4
UniProt:P29846-PRO_0000037666
0.616
5
UniProt:Q08426 EHHADH
2
EHHADH [peroxisomal matrix]
(R-HSA-400155)
EHHADH [cytosol]
(R-HSA-9033147)
0.556
3
UniProt:Q9UI14 PRAF1
0.556
3
UniProt:P0DTD8 NS7B
0.547
2
UniProt:Q96HA1 POM121
1
POM121 [nuclear envelope]
(R-HSA-157747)
0.527
2
UniProt:P0CG47 UBB
20
UBB(77-152) [endocytic vesicle membrane]
(R-HSA-939253)
UBB(1-76) [endocytic vesicle membrane]
(R-HSA-939231)
UBB(153-228) [endocytic vesicle membrane]
(R-HSA-939171)
Ub-33-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783023)
Ub-109-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783008)
Ub-185-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783046)
Ub-215-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783002)
Ub-63-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783148)
Ub-139-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783012)
Ub-158-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783162)
Ub-6-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783014)
Ub-82-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783015)
Ub-163-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783025)
Ub-87-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6782998)
Ub-11-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783109)
Ub-124-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783131)
Ub-200-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783100)
Ub-48-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783165)
Ub-181-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783160)
Ub-29-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783070)
0.527
2
UniProt:Q9NPF0 CD320
2
CD320 [plasma membrane]
(R-HSA-2980909)
CD320 E88del [plasma membrane]
(R-HSA-3325560)
0.527
2
UniProt:Q9H0F6 SHARPIN
1
SHARPIN [cytosol]
(R-HSA-5212666)
0.527
2
UniProt:P12755 SKI
1
SKI [nucleoplasm]
(R-HSA-173473)
0.527
2
UniProt:Q8WYA0 IFT81
2
IFT81 [cilium]
(R-HSA-5617769)
IFT81 [ciliary tip]
(R-HSA-5625369)
0.527
2
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.527
3
UniProt:Q13490 BIRC2
5
BIRC2 [cytosol]
(R-HSA-50847)
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
0.527
3
UniProt:Q9BYM8 RBCK1
1
RBCK1 [cytosol]
(R-HSA-976018)
0.527
2
UniProt:Q8N5K1 CISD2
0.527
2
UniProt:Q86XZ4 SPAS2
0.527
2
UniProt:Q96EP0 RNF31
1
RNF31 [cytosol]
(R-HSA-5212660)
0.527
2
UniProt:Q96A37 RN166
0.527
2
UniProt:Q6ZUS5 CC121
0.527
2
UniProt:P0CJ78 ZN865
0.527
2
UniProt:O43663 PRC1
1
PRC1 [cytosol]
(R-HSA-264441)
0.527
2
UniProt:Q9BR77 CCD77
0.527
2
UniProt:Q9H0I3 CF263
0.527
2
UniProt:Q96GE4 CEP95
0.527
2
UniProt:Q9BT92 TCHP
0.527
2
UniProt:Q15051 IQCB1
1
IQCB1 [cytosol]
(R-HSA-5626648)
0.527
2
UniProt:Q567U6 CCD93
0.527
2
UniProt:Q9HBM1 SPC25
1
SPC25 [cytosol]
(R-HSA-375307)
0.527
2
UniProt:Q9UL54 TAOK2
0.527
2
UniProt:Q8IXZ2 ZC3H3
0.527
2
UniProt:Q9H2G9 BLZF1
1
BLZF1 [Golgi membrane]
(R-HSA-2422372)
0.527
2
UniProt:O95229 ZWINT
1
ZWINT [cytosol]
(R-HSA-376254)
0.527
2
UniProt:Q8WTV1 THAP3
0.527
2
UniProt:O00411 POLRMT
1
POLRMT [mitochondrial matrix]
(R-HSA-163267)
0.527
2
UniProt:A8MTY0 ZNF724
1
ZNF724P [nucleoplasm]
(R-HSA-2586597)
0.527
2
UniProt:O43557 TNFSF14
1
TNFSF14 [plasma membrane]
(R-HSA-5667149)
0.524
3
UniProt:Q15326 ZMY11
0.508
5
UniProt:P36941 LTBR
1
LTBR [plasma membrane]
(R-HSA-5668750)
0.508
2
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