Lymphotoxin-beta receptor (LTBR or TNFR3) is a tumor necrosis factor receptor superfamily (TNFRSF) member that is expressed in lymphoid stromal and epithelial cells and binds two members of the TNFSF, the lymphotoxin alpha/beta (LTA/B) heterotrimers, as well as homotrimeric TNFSF14 (LIGHT) (Rooney et al. 2000, Aggarwal 2003). Both ligands are cytokines produced by activated lymphocytes that plays an important role in the inflammatory and immunologic response. LTA is a product of stimulated T cells and can help elicit cytotoxic effects on cancer cells (Stopfer et al. 2004, Crowe et al. 1994, Mauri et al. 1998, Ware et al. 1992). LTBR (TNFR3) signalling mediates responses controlling cellular differentiation, development and maintenance of peripheral lymphoid organs, dendritic cell homeostasis, hepatic regeneration, interferon responses to pathogens, and death of mucosal derived carcinomas (Norris & Ware 2007, Schneider et al. 2004).