Reactome | PAK2 phosphorylates myosin regulatory light chain (MRLC)

PAK2 phosphorylates myosin regulatory light chain (MRLC)

Stable Identifier

R-HSA-5668932

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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PAK2 phosphorylates myosin regulatory light chain (MRLC)

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PAK2, activated by CDC42 or RAC1 RHO GTPases, phosphorylates myosin regulatory light chain (MRLC, MYL9 or MYL12B) of the non-muscle myosin II complex on threonine residue T19 (also labeled in literature as T18). This leads to the rearrangement of the actin cytoskeleton and cell retraction (Chew et al. 1998, Zeng et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10047984	Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (gamma-PAK) Goeckeler, ZM, Masaracchia, RA, Wysolmerski, RB, Chew, TL	J. Muscle Res. Cell. Motil.	1998
10639334	Endothelial cell retraction is induced by PAK2 monophosphorylation of myosin II Wysolmerski, R, Goeckeler, Z, Zeng, Q, Masaracchia, R, Lagunoff, D, Côté, G	J. Cell. Sci.	2000