Reactome | p-T19-MYL12B [cytosol]

p-T19-MYL12B [cytosol]

Stable Identifier

R-HSA-5668936

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases activate PAKs (Homo sapiens)
        
        PAK2 phosphorylates myosin regulatory light chain (MRLC) (Homo sapiens)
        
        p-T19-MRLC-Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
        
        p-T19-MRLC [cytosol] (Homo sapiens)
        
        p-T19-MYL12B [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O14950 MYL12B

Gene Names

MYL12B, MRLC2, MYLC2B

Chain

chain:1-172

Reference Genes

BioGPS Gene:103910 MYL12B

BioGPS Gene:10627 MYL12B

COSMIC (genes):MYL12B MYL12B

CTD Gene:103910 MYL12B

CTD Gene:10627 MYL12B

dbSNP Gene:103910 MYL12B

dbSNP Gene:10627 MYL12B

ENSEMBL:ENSG00000118680 MYL12B

HGNC:29827 MYL12B

KEGG Gene (Homo sapiens):103910 MYL12B

Monarch:103910 MYL12B

Monarch:10627 MYL12B

NCBI Gene:103910 MYL12B

NCBI Gene:10627 MYL12B

UCSC:O14950 MYL12B

Reference Transcript

Other Identifiers

0004150600

103910

11744197_s_at

16850616

201318_s_at

221474_at

2796323

3591070

3776439

3776443

3776450

3776451

3776452

3776453

3776454

3776455

3776458

3776459

3776460

3776461

3776462

3776463

41187_at

63986_at

8019930

A_32_P42925

GE61295

GO:0003674

GO:0005509

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005829

GO:0005856

GO:0006936

GO:0008150

GO:0016459

GO:0032991

GO:0043167

GO:0043226

GO:0046872

GO:0070062

GO:0099738

HMNXSV003024931

ILMN_1654016

ILMN_1725204

PH_hs_0026604

TC18000017.hg

g829622_3p_at

g829622_3p_x_at

Participates

as a member of

p-T19-MRLC [cytosol] (Homo sapiens)

Other forms of this molecule

MYL12B [cytosol]

p-T19,S20-MYL12B [cytosol]

Inferred To

phospho-Myl12b [cytosol] (Mus musculus)

phospho-Myl12b [cytosol] (Rattus norvegicus)

phospho-rlc1 [cytosol] (Schizosaccharomyces pombe)

phospho-myl12.2 [cytosol] (Danio rerio)

phospho-MLC2 [cytosol] (Saccharomyces cerevisiae)

phospho-myl12.1 [cytosol] (Danio rerio)

phospho-mlcR [cytosol] (Dictyostelium discoideum)

phospho-mlc-2 [cytosol] (Caenorhabditis elegans)

phospho-sqh [cytosol] (Drosophila melanogaster)

phospho-mlc-1 [cytosol] (Caenorhabditis elegans)

phospho-CT39356 [cytosol] (Drosophila melanogaster)

phospho-p-T19-MYL12B [cytosol] (Canis familiaris)

phospho-mlc-4 [cytosol] (Caenorhabditis elegans)

phospho-MYL12B [cytosol] (Gallus gallus)

phospho-Mlc2 [cytosol] (Drosophila melanogaster)

Homologues of p-T19-MYL12B [cytosol] (Caenorhabditis elegans)

Homologues of p-T19-MYL12B [cytosol] (Danio rerio)

Homologues of p-T19-MYL12B [cytosol] (Drosophila melanogaster)

Modified Residues

Name

O-phospho-L-threonine at 19

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001138416.1, NP_001138417.1, NP_001289978.1, NP_291024.1

Target Pathogen

5b354852be737e166372ea62, 5b354852be737e166372e98f

OpenTargets

ENSG00000118680

GeneCards

O14950

HPA

ENSG00000118680-MYL12B

Ensembl

ENST00000648965, ENST00000581193, ENSG00000118680, ENSP00000383037, ENST00000584539, ENSP00000464464, ENST00000237500, ENST00000400175, ENSP00000496809, ENSP00000237500, ENSP00000463559

PRO

O14950

HMDB Protein

HMDBP07817

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB(1-375) [lysosomal membrane] (R-HSA-196160) ACTB(1-375) [nucleoplasm] (R-HSA-3321990) ACTB(1-375) [cytosol] (R-HSA-201861) ACTB(1-375) [plasma membrane] (R-HSA-196016)	0.537	3
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]	6	PI(4,5)P2 [endoplasmic reticulum membrane] (R-ALL-2023856) PI(4,5)P2 [plasma membrane] (R-ALL-179856) PI(4,5)P2 [Golgi membrane] (R-ALL-1806165) PI(4,5)P2 [nucleoplasm] (R-ALL-6810412) PI(4,5)P2 [cytoplasmic vesicle membrane] (R-ALL-8874467) PI(4,5)P2 [early endosome membrane] (R-ALL-8849966)	0.462	2

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