PAK1 phosphorylates myosin phosphatase

Stable Identifier
R-HSA-5668947
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PAK1 phosphorylates myosin phosphatase
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PAK1 phosphorylates the regulatory subunit MYPT1 (PPP1R12A) of the myosin phosphatase complex on threonine residue T696, thereby inhibiting the catalytic activity of the myosin phosphatase and indirectly increasing phosphorylation of the myosin regulatory light chain (MRLC) (Chu et al. 2013).
Literature References
PubMed ID Title Journal Year
23161543 Biphasic regulation of myosin light chain phosphorylation by p21-activated kinase modulates intestinal smooth muscle contractility

Stewart, RH, LeTourneau, PA, Chu, J, Kislitsyna, K, Kots, A, Day, MC, Olate, N, Uray, K, Laine, GA, Cox, CS, Pham, NT

J. Biol. Chem. 2013
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Catalyst Activity

protein serine/threonine kinase activity of p-S144,T423-PAK1 [cytosol]

Physical Entity
p-S144,T423-PAK1 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
PAK1 phosphorylates myosin phosphatase (Bos taurus)
PAK1 phosphorylates myosin phosphatase (Caenorhabditis elegans)
PAK1 phosphorylates myosin phosphatase (Canis familiaris)
PAK1 phosphorylates myosin phosphatase (Drosophila melanogaster)
PAK1 phosphorylates myosin phosphatase (Gallus gallus)
PAK1 phosphorylates myosin phosphatase (Mus musculus)
PAK1 phosphorylates myosin phosphatase (Rattus norvegicus)
PAK1 phosphorylates myosin phosphatase (Sus scrofa)
PAK1 phosphorylates myosin phosphatase (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-02-02)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2015-01-29)
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