Reactome | MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex

MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex

Stable Identifier

R-HSA-5668978

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex

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MYLK (MLCK) is a Ca2+/calmodulin-dependent myosin light chain kinase that phosphorylates myosin regulatory light chains (MRLC) MYL9 and MYL12B at threonine T19 and serine S20 (also labeled in literature as T18 and S19) (Ikebe and Hartshorne 1985, Ikebe et al. 1986).

Literature References

PubMed ID	Title	Journal	Year
3079756	Identification, phosphorylation, and dephosphorylation of a second site for myosin light chain kinase on the 20,000-dalton light chain of smooth muscle myosin Elzinga, M, Ikebe, M, Hartshorne, DJ	J Biol Chem	1986
3839510	Phosphorylation of smooth muscle myosin at two distinct sites by myosin light chain kinase Hartshorne, DJ, Ikebe, M	J. Biol. Chem.	1985

Participants

Input

Output

Participates

as an event of

RHO GTPases activate PAKs (Homo sapiens)

Catalyst Activity

myosin light chain kinase activity of MYLK:Ca2+:CALM1 [cytosol]

Physical Entity

MYLK:Ca2+:CALM1 [cytosol] (Homo sapiens)

Activity

myosin light chain kinase activity (GO:0004687)

This event is regulated

Negatively by

Regulator

Myosin phosphatase [cytosol] (Homo sapiens)

Inferred From

Turkey MYLK phosphorylates MRLCs of the non-muscle myosin II complex (Meleagris gallopavo)

Authored

Orlic-Milacic, M (2015-02-02)

Rivero Crespo, F (2014-12-26)

Created

Orlic-Milacic, M (2015-01-30)

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