Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
NF2 [plasma membrane]
Stable Identifier
R-HSA-5669168
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Merlin, Moesin-ezrin-radixin-like protein, Neurofibromin-2, Schwannomerlin, Schwannomin, SCH
Locations in the PathwayBrowser for interactor UniProt:Q5VYS8-5 TUT7
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
RAC1 and CDC42 activate PAK1 (Homo sapiens)
NF2 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases activate PAKs (Homo sapiens)
NF2 binds PAK1 (Homo sapiens)
NF2 [plasma membrane] (Homo sapiens)
RAC1 and CDC42 activate PAK1 (Homo sapiens)
NF2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35240 NF2
Gene Names
NF2, SCH
Chain
chain:1-595
Reference Genes
COSMIC (genes):NF2 NF2
dbSNP Gene:4771 NF2
ENSEMBL:ENSG00000186575 NF2
Participates
as a component of
PAK1:NF2 [plasma membrane] (Homo sapiens)
as an input of
NF2 binds PAK1 (Homo sapiens)
This entity regulates
Negatively
RAC1 and CDC42 activate PAK1
(Homo sapiens)
Inferred To
NF2 [plasma membrane]
(Bos taurus)
NF2 [plasma membrane]
(Canis familiaris)
NF2 [plasma membrane]
(Gallus gallus)
NF2 [plasma membrane]
(Sus scrofa)
NF2 [plasma membrane]
(Xenopus tropicalis)
nfm-1 [plasma membrane]
(Caenorhabditis elegans)
Mer [plasma membrane]
(Drosophila melanogaster)
Nf2 [plasma membrane]
(Mus musculus)
Nf2 [plasma membrane]
(Rattus norvegicus)
Interactors (43)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q4VCS5 AMOT
0.882
10
UniProt:Q8IY63 AMOTL1
1
AMOTL1 [cytosol]
(R-HSA-2028603)
0.725
5
UniProt:O14964 HGS
2
HGS [cytosol]
(R-HSA-182954)
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
0.7
7
UniProt:O60341 KDM1A
1
KDM1A [nucleoplasm]
(R-HSA-996769)
0.666
4
UniProt:Q16584 MAP3K11
1
MAP3K11 [cytosol]
(R-HSA-449607)
0.645
4
UniProt:Q9Y2J4 AMOTL2
1
AMOTL2 [cytosol]
(R-HSA-2028606)
0.643
3
UniProt:Q9BZE4 GTPB4
0.61
9
UniProt:Q4VCS5-2 AMOT
1
AMOT-2 [cytosol]
(R-HSA-9761473)
0.591
6
UniProt:Q9H204 MED28
1
MED28 [nucleoplasm]
(R-HSA-6804546)
0.581
4
UniProt:O76041 NEBL
0.556
3
UniProt:Q5TAQ9-2 Q5TAQ92
0.556
3
UniProt:Q99598 TSNAX
1
TSNAX [cytosol]
(R-HSA-5216130)
0.556
3
UniProt:Q96KP6 TNIP3
1
TNIP3 [cytosol]
(R-HSA-561192)
0.556
3
UniProt:Q8NEZ2 VPS37A
1
VPS37A [endosome membrane]
(R-HSA-184333)
0.556
3
UniProt:Q8WXF7 ATLA1
0.556
3
UniProt:Q86WT6-2 TRIM69
0.556
3
UniProt:Q5VYS8-5 TUT7
0.556
3
UniProt:Q8WWB5 PIHD2
0.556
3
UniProt:Q9C0F3 ZNF436
1
ZNF436 [nucleoplasm]
(R-HSA-1247538)
0.556
3
UniProt:Q6ZR37 PKHG7
0.556
3
UniProt:P17024 ZNF20
1
ZNF20 [nucleoplasm]
(R-HSA-975024)
0.556
3
UniProt:Q6ZNH5 ZN497
0.556
3
UniProt:Q14525 KRT33B
1
KRT33B [cytosol]
(R-HSA-6809594)
0.556
3
UniProt:Q15776 ZKSCAN8
1
ZKSCAN8 [nucleoplasm]
(R-HSA-974985)
0.556
3
UniProt:Q6ZNE9 RUFY4
0.556
3
UniProt:P54274-2 TERF1
0.556
3
UniProt:Q9BY12-3 Q9BY123
0.556
3
UniProt:Q6X4W1-6 NSMF
0.556
3
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.556
3
UniProt:O95835 LATS1
2
LATS1 [cytosol]
(R-HSA-2028562)
p-S909,T1079-LATS1 [cytosol]
(R-HSA-2028551)
0.556
4
UniProt:Q7Z3I7 ZN572
0.556
3
UniProt:Q8IZU1 FAM9A
0.556
3
UniProt:Q6H8Q1-8 ABLIM2
0.556
3
UniProt:Q9UNS2 COPS3
2
COPS3 [nucleoplasm]
(R-HSA-5697017)
COPS3 [cytosol]
(R-HSA-416973)
0.556
3
UniProt:O75530-2 EED
0.556
3
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.556
3
UniProt:O75925 PIAS1
1
PIAS1 [nucleoplasm]
(R-HSA-877307)
0.556
3
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.556
3
UniProt:P46937 YAP1
8
YAP1 [nucleoplasm]
(R-HSA-1253322)
YAP1 [cytosol]
(R-HSA-1253345)
p-S127-YAP1 [cytosol]
(R-HSA-2028553)
p-5S-YAP1 [cytosol]
(R-HSA-2028554)
p-Y-YAP1 [nucleoplasm]
(R-HSA-8937857)
p-Y-YAP1 [cytosol]
(R-HSA-8937843)
p-Y407-YAP1 [nucleoplasm]
(R-HSA-8956661)
p-Y407-YAP1 [cytosol]
(R-HSA-9865208)
0.527
2
UniProt:Q10728 Ppp1r12a
5
phospho-Ppp1r12a [nucleoplasm]
(R-RNO-3002801)
Phosphorylated (Thr-697, Ser-854) protein phosphatase 1 regulatory subunit 12A [cytosol]
(R-RNO-420999)
Protein phosphatase 1 regulatory subunit 12A [cytosol]
(R-RNO-420968)
phospho-Ppp1r12a [cytosol]
(R-RNO-5668956)
Ppp1r12a [cytosol]
(R-RNO-419070)
0.524
2
UniProt:P0DPB4 SCHI1
0.508
2
UniProt:Q4VCS5-1 AMOT
1
AMOT-1 [cytosol]
(R-HSA-2028607)
0.499
2
UniProt:Q8NI35 PATJ
1
PATJ [plasma membrane]
(R-HSA-420011)
0.499
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text