Reactome | ATG9A [phagophore assembly site membrane]

ATG9A [phagophore assembly site membrane]

Stable Identifier

R-HSA-5671732

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

phagophore assembly site membrane

Synonyms

mATG9, Autophagy-related protein 9A, ATG9A_HUMAN, Atg9L1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q7Z3C6 ATG9A

Gene Names

ATG9A, APG9L1

Chain

initiator methionine:, chain:2-839

Reference Genes

BioGPS Gene:79065 ATG9A

COSMIC (genes):ATG9A ATG9A

CTD Gene:79065 ATG9A

dbSNP Gene:79065 ATG9A

ENSEMBL:ENSG00000198925 ATG9A

HGNC:22408 ATG9A

KEGG:hsa:79065 ATG9A

Monarch:79065 ATG9A

NCBI Gene:79065 ATG9A

OMIM:612204 ATG9A

UCSC:Q7Z3C6 ATG9A

Reference Transcript

Participates

as a member of

ATG9A,(ATG9B) [phagophore assembly site membrane] (Homo sapiens)

as a component of

ATG9A:p-S172-TBK1:p-S177-OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane] (Homo sapiens)

as an input of

OPTN binds ATG9A (Homo sapiens)

Inferred To

atg9a [phagophore assembly site membrane] (Danio rerio)

atg9a [phagophore assembly site membrane] (Xenopus tropicalis)

ATG9A [phagophore assembly site membrane] (Bos taurus)

ATG9A [phagophore assembly site membrane] (Canis familiaris)

ATG9A [phagophore assembly site membrane] (Gallus gallus)

ATG9A [phagophore assembly site membrane] (Sus scrofa)

Atg9 [phagophore assembly site membrane] (Drosophila melanogaster)

ATG9 [phagophore assembly site membrane] (Saccharomyces cerevisiae)

atg9 [phagophore assembly site membrane] (Dictyostelium discoideum)

atg9 [phagophore assembly site membrane] (Schizosaccharomyces pombe)

atg-9 [phagophore assembly site membrane] (Caenorhabditis elegans)

Atg9a [phagophore assembly site membrane] (Mus musculus)

Atg9a [phagophore assembly site membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001070666.1, NP_076990.4

OpenTargets

ENSG00000198925

ENSEMBL

ENSP00000386482, ENST00000409033, ENST00000361242, ENSP00000379983, ENST00000409422, ENST00000396761, ENSP00000386535, ENSP00000355173, ENSG00000198925, ENSP00000386710, ENST00000409618

HPA

ENSG00000198925-ATG9A

GeneCards

ATG9A

PRO

Q7Z3C6

Pharos - Targets

Q7Z3C6

GlyGen

Q7Z3C6

PDB

7JLO, 8KBZ, 7JLQ, 8KC3, 6WR4, 8Y1L, 6WQZ, 7JLP

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96CW1 AP2M1	6	AP2M1 [plasma membrane] (R-HSA-167585) AP2M1 [lysosomal membrane] (R-HSA-196144) AP2M1 [cytosol] (R-HSA-182227) AP2M1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130423) AP2M1 [endolysosome membrane] (R-HSA-6784828) p-T156 AP2M1 [cytosol] (R-HSA-8856805)	0.895	22
UniProt:Q8NEM7-2 SUPT20H			0.653	8
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q9BYR5 KRTAP4-2	1	KRTAP4-2 [cytosol] (R-HSA-6809948)	0.556	3
UniProt:Q04864 REL	2	REL [cytosol] (R-HSA-1168579) REL [nucleoplasm] (R-HSA-1168585)	0.556	3
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.556	3
UniProt:Q17RB8 LONRF1	1	LONRF1 [cytosol] (R-HSA-8850905)	0.556	3
UniProt:Q05086-2 UBE3A			0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.527	2
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.527	2
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.527	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.527	2
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.527	2
UniProt:Q2TAZ0 ATG2A			0.499	4
UniProt:Q9UHD2 TBK1	5	p-S172-TBK1 [cytosol] (R-HSA-168379) TBK1 [cytosol] (R-HSA-166267) K63polyUb-K30,K401-TBK1 [cytosol] (R-HSA-9730430) p-TBK1 [cytosol] (R-HSA-9008705) pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397)	0.499	2
UniProt:Q96QK1 VPS35	1	VPS35 [cytosol] (R-HSA-3247740)	0.463	2
UniProt:Q9UBQ0 VPS29	1	VPS29 [cytosol] (R-HSA-3247738)	0.462	2

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