Reactome | p-T774-PKN1 phosphorylates PPP1R14A

p-T774-PKN1 phosphorylates PPP1R14A

Stable Identifier

R-HSA-5671763

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Activated PKN1 (p-T774-PKN1) phosphorylates PPP1R14A (CPI-17), an inhibitor of myosin light chain phosphatase complex (MLPC), on threonine residue T38 (Hamaguchi et al. 2000), and high levels of PKN1 activity correlate with high levels of PPP1R14A phosphorylation (Lartey et al. 2007). It is not certain that PKN1 can directly bind PPP1R14A, and C family protein kinases (PKCs) may be the main PPP1R14A kinases (Zemlickova et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15003508	Association of CPI-17 with protein kinase C and casein kinase I Dubois, T, Johannes, FJ, Zemlickova, E, Aitken, A	Biochem. Biophys. Res. Commun.	2004
17301291	Up-regulation of myometrial RHO effector proteins (PKN1 and DIAPH1) and CPI-17 (PPP1R14A) phosphorylation in human pregnancy is associated with increased GTP-RHOA in spontaneous preterm labor Strachan, B, Lartey, J, Smith, M, Mellor, H, Pawade, J, López Bernal, A	Biol. Reprod.	2007
10924361	Phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by protein kinase N Hartshorne, DJ, Kaibuchi, K, Seko, T, Ito, M, Feng, J, Nakano, T, Takase, K, Machida, H, Koyama, M, Hamaguchi, T, Amano, M	Biochem. Biophys. Res. Commun.	2000