Reactome | CDC42 [endoplasmic reticulum membrane]

CDC42 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-5672086

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Cell division control protein 42 homolog, CDC42_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:O15511 ARPC5

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-12 family signaling (Homo sapiens)
      - Interleukin-12 signaling (Homo sapiens)
        
        Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
        
        Expression of cell division cycle 42 (Homo sapiens)
        
        CDC42 [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P60953 CDC42

Gene Names

CDC42, cell division cycle 42

Chain

chain:1-188, propeptide:189-191

Reference Genes

COSMIC (genes):CDC42 CDC42

dbSNP Gene:998 CDC42

ENSEMBL:ENSG00000070831 CDC42

Participates

as a component of

CDC42:GTP [endoplasmic reticulum membrane] (Homo sapiens)

as an output of

Expression of cell division cycle 42 (Homo sapiens)

as a member of

RHOA,RHOG,RAC1,CDC42 [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

CDC42 [cytosol]

CDC42 [plasma membrane]

Inferred To

cdc42 [endoplasmic reticulum membrane] (Danio rerio)

cdc42 [endoplasmic reticulum membrane] (Xenopus tropicalis)

CDC42 [endoplasmic reticulum membrane] (Bos taurus)

CDC42 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

CDC42 [endoplasmic reticulum membrane] (Canis familiaris)

CDC42 [endoplasmic reticulum membrane] (Dictyostelium discoideum)

CDC42 [endoplasmic reticulum membrane] (Drosophila melanogaster)

CDC42 [endoplasmic reticulum membrane] (Gallus gallus)

CDC42 [endoplasmic reticulum membrane] (Mus musculus)

CDC42 [endoplasmic reticulum membrane] (Rattus norvegicus)

CDC42 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

CDC42 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

CDC42 [endoplasmic reticulum membrane] (Sus scrofa)

Interactors (52)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.957	19
UniProt:P42768 WAS	2	p-Y291-WAS [cytosol] (R-HSA-2197668) WAS [cytosol] (R-HSA-201879)	0.949	14
UniProt:Q13153 PAK1	5	p-S144,T423-PAK1 [cytosol] (R-HSA-399819) PAK1 [cytosol] (R-HSA-162629) Active PAK1 [cytosol] (R-HSA-8964622) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) PAK1 [plasma membrane] (R-HSA-3928409)	0.944	15
UniProt:Q9BYG5 PARD6B	2	PARD6B [plasma membrane] (R-HSA-418193) PARD6B [cytosol] (R-HSA-419973)	0.896	18
UniProt:Q00587 CDC42EP1	1	CDC42EP1 [cytosol] (R-HSA-9691382)	0.886	9
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524)	0.874	9
UniProt:O14613 CDC42EP2	2	p-CDC42EP2 [cytosol] (R-HSA-5692662) CDC42EP2 [cytosol] (R-HSA-5692692)	0.83	10
UniProt:O96013 PAK4	1	PAK4 [cytosol] (R-HSA-428461)	0.825	5
UniProt:Q5VT25 CDC42BPA	1	CDC42BPA [cytosol] (R-HSA-419871)	0.815	6
GTP [ChEBI:15996]	7	GTP [cilium] (R-ALL-5617813) GTP [early endosome membrane] (R-ALL-2130170) GTP [lysosomal membrane] (R-ALL-2213216) GTP [platelet dense granule lumen] (R-ALL-114625) GTP [cytoplasmic vesicle membrane] (R-ALL-1996291) GTP [ER to Golgi transport vesicle membrane] (R-ALL-983318) GTP [Golgi membrane] (R-ALL-1806221)	0.797	8
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.794	10
UniProt:P52565 ARHGDIA	1	ARHGDIA [cytosol] (R-HSA-194478)	0.756	5
UniProt:Q9NPB6 PARD6A	4	PARD6A [plasma membrane] (R-HSA-418187) PARD6A [cytosol] (R-HSA-420001) PARD6A [cell junction] (R-HSA-2134480) p-S345-PARD6A [plasma membrane] (R-HSA-2134533)	0.755	7
UniProt:O00401 WASL	4	p-Y256-WASL [cytosol] (R-HSA-2197672) N-WASP [cytosol] (R-HSA-201873) WASL [plasma membrane] (R-HSA-203010) WASL [endocytic vesicle membrane] (R-HSA-535012)	0.75	4
UniProt:Q9P286 PAK5	2	PAK5 [cytosol] (R-HSA-428459) PAK7 [plasma membrane] (R-HSA-211555)	0.743	5
UniProt:Q9JK83	2	Pard6b [plasma membrane] (R-MMU-418193) Pard6b [cytosol] (R-MMU-419973)	0.729	6
UniProt:Q9NRR3 CDC42SE2	1	CDC42SE2 [plasma membrane] (R-HSA-9714853)	0.725	5
UniProt:Q13576 IQGAP2	3	IQGAP2 [plasma membrane] (R-HSA-6804811) IQGAP2 [secretory granule membrane] (R-HSA-6804779) IQGAP2 [cytosol] (R-HSA-5625975)	0.688	4
UniProt:Q9BYG4 PARD6G	2	PARD6G [plasma membrane] (R-HSA-418192) PARD6G [cytosol] (R-HSA-419967)	0.681	5
UniProt:P19878 NCF2	2	NCF2 [cytosol] (R-HSA-1222600) p-T233-NCF2 [phagolysosome] (R-HSA-1996211)	0.676	3
UniProt:P41743 PRKCI	3	PRKCI [nucleoplasm] (R-HSA-9021345) PRKCI [cytosol] (R-HSA-58206) PRKCI [plasma membrane] (R-HSA-420005)	0.67	5
UniProt:P25054 APC	20	APC R213* [cytosol] (R-HSA-9666924) APC C1410* [cytosol] (R-HSA-9666925) APC K1310* [cytosol] (R-HSA-9666926) APC R499* [cytosol] (R-HSA-9666927) APC R1450* [cytosol] (R-HSA-5251499) APC G1357* [cytosol] (R-HSA-9666940) APC L1488* [cytosol] (R-HSA-9666941) APC S1400* [cytosol] (R-HSA-9666942) APC S1346* [cytosol] (R-HSA-9666943) APC R405* [cytosol] (R-HSA-9666936) APC S1281* [cytosol] (R-HSA-9666937) APC E1573* [cytosol] (R-HSA-9666938) APC R805* [cytosol] (R-HSA-9666939) APC R1386* [cytosol] (R-HSA-9666932) APC S1327* [cytosol] (R-HSA-9666933) APC E1209* [cytosol] (R-HSA-9666934) APC Q1469* [cytosol] (R-HSA-9666935) APC R564* [cytosol] (R-HSA-9666928) APC E1536* [cytosol] (R-HSA-9666929) APC G1288* [cytosol] (R-HSA-9666930)	0.668	9
UniProt:Q9UQB8-4 BAIAP2			0.667	4
UniProt:Q9NQU5 PAK6	1	PAK6 [cytosol] (R-HSA-428454)	0.659	4
UniProt:Q9NRR8 C42S1			0.659	3
UniProt:Q61036 Pak3	3	phospho-p-S154,T436-PAK3 [plasma membrane] (R-MMU-3928479) phospho-p-S154,T436-PAK3 [cytosol] (R-MMU-5357471) Pak3 [cytosol] (R-MMU-442833)	0.656	3
UniProt:Q86VI3 IQGAP3	1	IQGAP3 [cytosol] (R-HSA-5625977)	0.643	5
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.621	3
UniProt:Q92963 RIT1	1	RIT1 [plasma membrane] (R-HSA-187703)	0.619	6
UniProt:Q15642 TRIP10	1	TRIP10 [cytosol] (R-HSA-195120)	0.609	2
UniProt:O30916 SOPB			0.602	5
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.573	2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.564	2
UniProt:O52623 SOPE			0.558	2
UniProt:Q00587-2 CDC42EP1			0.556	3
UniProt:Q8WUI4-6 HDAC7			0.556	3
UniProt:B2RTY4 MYO9A	1	MYO9A [cytosol] (R-HSA-200628)	0.553	2
UniProt:Q9H3Q1 CDC42EP4	1	CDC42EP4 [cytosol] (R-HSA-9691381)	0.547	2
UniProt:P35268 RPL22	1	RPL22 [cytosol] (R-HSA-72428)	0.547	2
UniProt:P52306 RAP1GDS1	1	RAP1GDS1 [mitochondrial outer membrane] (R-HSA-9693756)	0.547	2
UniProt:Q9Y5S2 CDC42BPB	1	CDC42BPB [cytosol] (R-HSA-419873)	0.547	2
UniProt:Q16584 MAP3K11	1	MAP3K11 [cytosol] (R-HSA-449607)	0.536	3
UniProt:Q9VEX9	1	Bin1 [nucleoplasm] (R-DME-351694)	0.527	2
UniProt:P60660 MYL6	2	p-S20-MYL6 [cytosol] (R-HSA-445778) MYL6 [cytosol] (R-HSA-419186)	0.527	2
UniProt:Q9UHB6 LIMA1			0.527	2
UniProt:O15511 ARPC5	4	ARPC5 [ficolin-1-rich granule lumen] (R-HSA-6801065) ARPC5 [extracellular region] (R-HSA-6806476) ARPC5 [secretory granule lumen] (R-HSA-6801071) ARPC5 [cytosol] (R-HSA-200806)	0.527	2
UniProt:O08816 Wasl	1	N-Wasp [cytosol] (R-RNO-442543)	0.524	2
UniProt:P60953 CDC42	3	CDC42 [cytosol] (R-HSA-442630) CDC42 [plasma membrane] (R-HSA-449545) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086)	0.524	2
UniProt:O95477 ABCA1	11	ABCA1 [plasma membrane] (R-HSA-194209) 4xPALM-C-p-2S-ABCA1 [plasma membrane] (R-HSA-5682069) 4xPALM-C-ABCA1 [endoplasmic reticulum membrane] (R-HSA-5682085) 4xPALM-C-ABCA1 [plasma membrane] (R-HSA-5682091) ABCA1 [endoplasmic reticulum membrane] (R-HSA-5682105) ABCA1 Q537R [plasma membrane] (R-HSA-5682199) ABCA1 R587W [plasma membrane] (R-HSA-5682197) ABCA1 S1446L [plasma membrane] (R-HSA-5682195) ABCA1 C1417R [plasma membrane] (R-HSA-5682190) ABCA1 N935S [plasma membrane] (R-HSA-5682200) ABCA1 W590S [plasma membrane] (R-HSA-5682201)	0.524	2
UniProt:Q96L34 MARK4	1	MARK4 [cytosol] (R-HSA-5626653)	0.499	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	11
UniProt:P45983 MAPK8	3	MAPK8 [cytosol] (R-HSA-168141) p-T,Y-MAPK8 [cytosol] (R-HSA-194371) p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349)	0.483	2

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