Reactome | KSR2 [cytosol]

KSR2 [cytosol]

Stable Identifier

R-HSA-5672589

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - MAP2K and MAPK activation (Homo sapiens)
        
        Dissociation of RAS:RAF complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        KSR2 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        KSR2 [cytosol] (Homo sapiens)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        KSR2 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        KSR2 [cytosol] (Homo sapiens)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        KSR2 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        KSR2 [cytosol] (Homo sapiens)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        KSR2 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        KSR2 [cytosol] (Homo sapiens)
        
        MAP2Ks phosphorylate MAPKs (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        KSR2 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        KSR2 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        KSR2 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        KSR2 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        KSR2 [cytosol] (Homo sapiens)
        
        RAF phosphorylates MAP2K dimer (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        KSR2 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        KSR2 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        KSR2 [cytosol] (Homo sapiens)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        KSR2 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        KSR2 [cytosol] (Homo sapiens)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        KSR2 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        KSR2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q6VAB6 KSR2

Gene Names

KSR2

Chain

chain:1-950

Reference Genes

BioGPS Gene:283455 KSR2

COSMIC (genes):KSR2 KSR2

CTD Gene:283455 KSR2

dbSNP Gene:283455 KSR2

ENSEMBL:ENSG00000171435 KSR2

HGNC:18610 KSR2

KEGG Gene (Homo sapiens):283455 KSR2

Monarch:283455 KSR2

NCBI Gene:283455 KSR2

OMIM:610737 KSR2

UCSC:Q6VAB6 KSR2

Reference Transcript

Other Identifiers

0006420438

11743720_s_at

1553491_at

16770888

230551_at

283455

3473583

3473584

3473585

3473594

3473595

3473596

3473597

3473598

3473599

3473601

3473602

3473603

3473604

3473608

3473610

3473614

3473616

3473617

3473618

3473621

3473622

3473623

3473626

3473627

3473647

3473662

3473675

3473676

3473677

3473690

3473708

3473710

3473712

3473713

58703_at

7966810

A_32_P216635

GE478081

GE819786

GO:0000166

GO:0003674

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0005886

GO:0006464

GO:0006468

GO:0007165

GO:0007265

GO:0008150

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0019722

GO:0035556

GO:0042592

GO:0043167

GO:0046872

GO:0106310

GO:0106311

GO:0120162

HMNXSV003018327

HMNXSV003051090

Hs.107331.0.A1_3p_at

ILMN_1794514

ILMN_1885628

PH_hs_0024255

TC12002015.hg

TC12003110.hg

TC12003111.hg

Participates

as a candidate of

RAF/MAPK scaffolds [cytosol] (Homo sapiens)

Inferred To

Homologues of KSR2 [cytosol] (Caenorhabditis elegans)

Homologues of KSR2 [cytosol] (Dictyostelium discoideum)

KSR2 [cytosol] (Bos taurus)

KSR2 [cytosol] (Canis familiaris)

KSR2 [cytosol] (Gallus gallus)

KSR2 [cytosol] (Sus scrofa)

ksr2 [cytosol] (Danio rerio)

ksr2 [cytosol] (Xenopus tropicalis)

zakA [cytosol] (Dictyostelium discoideum)

ksr [cytosol] (Drosophila melanogaster)

splA [cytosol] (Dictyostelium discoideum)

Ksr2 [cytosol] (Mus musculus)

Ksr2 [cytosol] (Rattus norvegicus)

ksr-2 [cytosol] (Caenorhabditis elegans)

zak2 [cytosol] (Dictyostelium discoideum)

ksr-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

XP_011536527.1, NP_775869.3

Guide to Pharmacology - Targets

2052

OpenTargets

ENSG00000171435

IntEnz

2.7.11.1

GeneCards

Q6VAB6

HPA

ENSG00000171435-KSR2

Ensembl

ENSP00000339952, ENSG00000171435, ENST00000339824

PRO

Q6VAB6

Pharos - Targets

Q6VAB6

Orphanet

27529

HMDB Protein

HMDBP10936

PDB

7JUS, 2Y4I, 7JUT, 7JUQ, 7JUU, 5KKR, 7JUV, 7JUR

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07900 HSP90AA1	8	HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.669	6
UniProt:Q13451 FKBP5	2	FKBP5 [cytosol] (R-HSA-5618096) FKBP5 [nucleoplasm] (R-HSA-8939165)	0.669	7
UniProt:P36507 MAP2K2	12	MAP2K2(1-10) [cytosol] (R-HSA-5211334) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 Y134C [cytosol] (R-HSA-9652089) p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073)	0.527	7
UniProt:Q02750 MAP2K1	20	MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67N [cytosol] (R-HSA-9652016) MAP2K1 Q56P [cytosol] (R-HSA-9652064) MAP2K1 E203K [cytosol] (R-HSA-9652023) MAP2K1 V60E [cytosol] (R-HSA-9652067) MAP2K1 P124S [cytosol] (R-HSA-9652062) MAP2K1 Y130C [cytosol] (R-HSA-9652101) MAP2K1 C121S [cytosol] (R-HSA-9652013) MAP2K1 G128V [cytosol] (R-HSA-9652047) MAP2K1 F53L [cytosol] (R-HSA-9652031) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 E44_E57del [cytosol] (R-HSA-9652026)	0.527	7
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.527	6
UniProt:P53041 PPP5C	2	PPP5C [nucleoplasm] (R-HSA-5683410) PPP5C [cytosol] (R-HSA-5675402)	0.527	6
UniProt:Q93008 USP9X	1	USP9X [cytosol] (R-HSA-870499)	0.527	6
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.527	6
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.527	6
UniProt:P19388 POLR2E	2	POLR2E [nucleoplasm] (R-HSA-83713) POLR2E [cytosol] (R-HSA-1964438)	0.527	6

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