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MARK3 [cytosol]
Stable Identifier
R-HSA-5672591
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
CTAK1, EMK2
Locations in the PathwayBrowser for interactor UniProt:Q8WXK3 ASB13
Expand all
Developmental Biology (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
Transcriptional and post-translational regulation of MITF-M expression and activity (Homo sapiens)
MARK3 phosphorylates MITF-M on S173 (Homo sapiens)
MARK3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P27448 MARK3
Gene Names
MARK3, CTAK1, EMK2
Chain
chain:1-753
Reference Genes
BioGPS Gene:4140 MARK3
COSMIC (genes):MARK3 MARK3
CTD Gene:4140 MARK3
dbSNP Gene:4140 MARK3
ENSEMBL:ENSG00000075413 MARK3
HGNC:6897 MARK3
KEGG:hsa:4140 MARK3
Monarch:4140 MARK3
NCBI Gene:4140 MARK3
OMIM:602678 MARK3
UCSC:P27448 MARK3
Reference Transcript
RefSeq:NM_002376.6 MARK3
RefSeq:NM_001128918.2 MARK3
RefSeq:NM_001128921.2 MARK3
RefSeq:NM_001128919.2 MARK3
RefSeq:NM_001128920.2 MARK3
Other Identifiers
11725990_a_at
11738809_s_at
11740434_x_at
11754373_a_at
16789209
202568_PM_s_at
202568_s_at
202569_PM_s_at
202569_s_at
3553691
3553692
3553693
3553694
3553695
3553698
3553699
3553703
3553707
3553714
3553716
3553717
3553718
3553719
3553721
3553722
3553723
3553724
3553725
3553726
3553727
3553728
3553729
3553730
3553731
3553732
3553733
3553736
3553737
3553738
3553739
3553740
3553741
3553742
3553743
3553744
3553746
3553747
3553748
3553749
3553750
3553754
3553755
3553756
3553757
3553758
3553759
3553796
3553797
40826_at
4140
49762_at
69045_r_at
7977077
A_14_P107933
A_14_P112370
A_23_P140111
A_33_P3593546
GE58088
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005737
GO:0005829
GO:0005886
GO:0006468
GO:0008092
GO:0016301
GO:0016740
GO:0018105
GO:0030425
GO:0032092
GO:0035331
GO:0035556
GO:0036289
GO:0042995
GO:0043226
GO:0048156
GO:0050321
GO:0070062
GO:0106310
GO:0140096
GO:1900181
HMNXSV003007003
Hs.172766.0.S1_3p_s_at
ILMN_1704795
M80359_at
PH_hs_0025626
PH_hs_0033415
TC14000799.hg
g4505102_3p_a_at
Participates
as a component of
p-S311,S406 KSR1:MARK3 [cytosol] (Homo sapiens)
KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311 KSR1:MARK3 [cytosol] (Homo sapiens)
p-S311,T602 KSR1:MARK3 [plasma membrane] (Homo sapiens)
Inferred To
MARK3 [cytosol]
(Bos taurus)
MARK3 [cytosol]
(Caenorhabditis elegans)
MARK3 [cytosol]
(Canis familiaris)
MARK3 [cytosol]
(Dictyostelium discoideum)
MARK3 [cytosol]
(Drosophila melanogaster)
MARK3 [cytosol]
(Gallus gallus)
MARK3 [cytosol]
(Mus musculus)
MARK3 [cytosol]
(Plasmodium falciparum)
MARK3 [cytosol]
(Rattus norvegicus)
MARK3 [cytosol]
(Sus scrofa)
MARK3 [cytosol]
(Xenopus tropicalis)
Homologues of MARK3 [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_002367.5
,
NP_001122392.2
,
NP_001122393.2
,
NP_001122390.2
,
NP_001122391.2
Guide to Pharmacology - Targets
2099
OpenTargets
ENSG00000075413
ENSEMBL
ENSG00000075413
,
ENSP00000303698
,
ENST00000440884
,
ENSP00000411397
,
ENST00000416682
,
ENST00000303622
,
ENSP00000216288
,
ENSP00000402104
,
ENST00000429436
,
ENSP00000450772
,
ENST00000553942
,
ENSP00000408092
,
ENST00000216288
ZINC - FDA approved
MARK3_HUMAN
ZINC - Substances
MARK3_HUMAN
ZINC - Biogenic
MARK3_HUMAN
ZINC target
P27448
PRO
P27448
GlyGen
P27448
PDB
3FE3
,
8UOI
,
7P1L
,
8UOH
,
8UOL
,
8UOK
,
2QNJ
ZINC - Investigational
MARK3_HUMAN
HPA
ENSG00000075413-MARK3
GeneCards
MARK3
Pharos - Targets
P27448
ZINC - Predictions - Purchasable
MARK3_HUMAN
HMDB Protein
HMDBP01179
Interactors (23)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.944
17
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.916
13
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.916
13
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.906
13
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.859
9
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.786
9
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.72
5
UniProt:Q7KZI7 MARK2
0.643
3
IntAct:EBI-4399559 UBIQ
0.558
2
UniProt:P47756 CAPZB
1
CAPZB [cytosol]
(R-HSA-879409)
0.527
2
UniProt:Q96L34 MARK4
1
MARK4 [cytosol]
(R-HSA-5626653)
0.527
2
UniProt:P11309 PIM1
1
PIM1 [nucleoplasm]
(R-HSA-3215094)
0.527
2
UniProt:P0DTD2 9b
3
p-S53-9b [cytosol]
(R-COV-9758478)
9b [cytosol]
(R-COV-9694649)
9b [mitochondrial outer membrane]
(R-COV-9709803)
0.527
2
UniProt:O94964 MTCL2
0.527
2
UniProt:Q8TDM6 DLG5
1
DLG5 [plasma membrane]
(R-HSA-9715164)
0.527
2
UniProt:Q9Y4B5 MTCL1
0.527
2
UniProt:Q8BHN0
1
PPM1L [endoplasmic reticulum membrane]
(R-MMU-429688)
0.524
3
UniProt:Q8WXK3 ASB13
1
ASB13 [cytosol]
(R-HSA-975427)
0.508
2
UniProt:Q6S8E0 Q6S8E0
0.508
2
UniProt:Q15560 TCEA2
0.508
2
UniProt:O60741 HCN1
1
HCN1 [plasma membrane]
(R-HSA-977503)
0.499
5
UniProt:Q86UR5 RIMS1
1
RIMS1 [cytosol]
(R-HSA-210407)
0.499
3
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.483
4
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