Reactome | CNKSR2 [cytosol]

CNKSR2 [cytosol]

Stable Identifier

R-HSA-5672632

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - MAP2K and MAPK activation (Homo sapiens)
        
        Dissociation of RAS:RAF complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR2 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR2 [cytosol] (Homo sapiens)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR2 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR2 [cytosol] (Homo sapiens)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR2 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR2 [cytosol] (Homo sapiens)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR2 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR2 [cytosol] (Homo sapiens)
        
        MAP2Ks phosphorylate MAPKs (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR2 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR2 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR2 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR2 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR2 [cytosol] (Homo sapiens)
        
        RAF phosphorylates MAP2K dimer (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR2 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR2 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR2 [cytosol] (Homo sapiens)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR2 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR2 [cytosol] (Homo sapiens)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR2 [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        RAF/MAPK scaffolds [cytosol] (Homo sapiens)
        
        CNKSR2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8WXI2 CNKSR2

Gene Names

CNKSR2, CNK2, KIAA0902, KSR2

Chain

chain:1-1034

Reference Genes

BioGPS Gene:22866 CNKSR2

COSMIC (genes):CNKSR2 CNKSR2

CTD Gene:22866 CNKSR2

dbSNP Gene:22866 CNKSR2

ENSEMBL:ENSG00000149970 CNKSR2

ENSEMBL_homo_sapiens_GENE:ENSG00000149970.16 CNKSR2

HGNC:19701 CNKSR2

KEGG Gene (Homo sapiens):22866 CNKSR2

Monarch:22866 CNKSR2

NCBI Gene:22866 CNKSR2

OMIM:300724 CNKSR2

UCSC:Q8WXI2 CNKSR2

Reference Transcript

Other Identifiers

11736639_a_at

11759207_at

11760118_a_at

1554607_PM_at

1554607_at

17101990

206731_PM_at

206731_at

22866

229116_PM_at

229116_at

238832_PM_at

238832_at

34418_at

3971218

3971220

3971221

3971230

3971231

3971232

3971235

3971237

3971238

3971240

3971241

3971247

3971251

3971252

3971257

3971258

3971262

3971263

3971264

3971265

3971266

3971267

3971269

3971270

3971271

3971272

3971277

3971278

3971279

3971280

3971281

3971282

3971283

3971284

3971285

3971286

3971288

42822_at

53487_at

8166355

83196_at

A_14_P104036

A_14_P112319

A_14_P112489

A_23_P153183

GE53573

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005886

GO:0009966

GO:0014069

GO:0016020

GO:0019901

GO:0023052

GO:0034330

GO:0035556

GO:0042802

GO:0043025

GO:0043226

GO:0045211

GO:0070062

GO:0098978

GO:0099147

GO:0099173

HMNXSV003001170

Hs.150353.0.A1_3p_at

Hs.78406.1.A1_3p_at

Hs2.100527.2.S1_3p_at

ILMN_1795756

PH_hs_0035504

TC0X000097.hg

g7662367_3p_at

Participates

as a candidate of

RAF/MAPK scaffolds [cytosol] (Homo sapiens)

Inferred To

CNKSR2 [cytosol] (Bos taurus)

CNKSR2 [cytosol] (Canis familiaris)

CNKSR2 [cytosol] (Gallus gallus)

CNKSR2 [cytosol] (Sus scrofa)

Cnksr2 [cytosol] (Mus musculus)

Cnksr2 [cytosol] (Rattus norvegicus)

cnk [cytosol] (Drosophila melanogaster)

cnk-1 [cytosol] (Caenorhabditis elegans)

cnksr2 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001162119.1, NP_001162120.1, NP_001162118.1, NP_055742.2

OpenTargets

ENSG00000149970

HPA

ENSG00000149970-CNKSR2

GeneCards

Q8WXI2

Ensembl

ENSP00000368824, ENST00000379510, ENSP00000496709, ENSP00000397906, ENST00000642359, ENSP00000444633, ENST00000543067, ENSG00000149970, ENST00000425654

PRO

Q8WXI2

Pharos - Targets

Q8WXI2

Orphanet

23631

PDB

2EAN, 3BS5

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.508	2

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