Reactome | p-S214,S582 ARAF [cytosol]

p-S214,S582 ARAF [cytosol]

Stable Identifier

R-HSA-5672639

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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External Reference Information

External Reference

UniProt:P10398 ARAF

Gene Names

ARAF, ARAF1, PKS, PKS2

Chain

chain:1-606

Reference Genes

BioGPS Gene:369 ARAF

COSMIC (genes):ARAF ARAF

CTD Gene:369 ARAF

dbSNP Gene:369 ARAF

ENSEMBL:ENSG00000078061 ARAF

HGNC:646 ARAF

KEGG:hsa:369 ARAF

Monarch:369 ARAF

NCBI Gene:369 ARAF

OMIM:311010 ARAF

UCSC:P10398 ARAF

Reference Transcript

Other Identifiers

11728747_s_at

11728748_x_at

11752388_a_at

11756111_a_at

11763195_at

1706_at

1707_g_at

17103160

201895_PM_at

201895_at

230652_PM_at

230652_at

369

3976275

3976302

3976308

3976309

3976310

3976312

3976313

3976315

3976316

3976317

3976318

3976319

3976320

3976322

3976323

3976324

3976327

3976328

3976329

3976330

3976331

3976332

3976334

3976335

3976336

3976337

3976338

3976339

3976340

58393_at

8167165

A_14_P110286

A_14_P126705

A_23_P73511

A_33_P3362353

GE79947

GO:0000165

GO:0001934

GO:0003824

GO:0004672

GO:0004674

GO:0004709

GO:0005515

GO:0005524

GO:0005575

GO:0005739

GO:0005829

GO:0006468

GO:0007165

GO:0016740

GO:0032006

GO:0032434

GO:0033138

GO:0036211

GO:0043066

GO:0043226

GO:0046872

GO:0106310

GO:0140096

GO:1902531

HMNXSV003053579

HMNXSV003056217

Hs.77183.1.A1_3p_at

M13829_s_at

PH_hs_0034517

TC0X000237.hg

TC0X001688.hg

U01337_at

g4502192_3p_at

g4502192_3p_x_at

p26937

Participates

as a member of

inactive RAFs [cytosol] (Homo sapiens)

Other forms of this molecule

p-S299,S302,T452,T455,S582 ARAF [cytosol]

p-S299,S302,T452,T455,S582 ARAF [plasma membrane]

p-S582 ARAF [cytosol]

Inferred To

phospho-ARAF [cytosol] (Canis familiaris)

Homologues of p-S214,S582 ARAF [cytosol] (Plasmodium falciparum)

phospho-p-S214,S582 ARAF [cytosol] (Bos taurus)

phospho-p-S214,S582 ARAF [cytosol] (Caenorhabditis elegans)

phospho-p-S214,S582 ARAF [cytosol] (Danio rerio)

phospho-p-S214,S582 ARAF [cytosol] (Drosophila melanogaster)

phospho-p-S214,S582 ARAF [cytosol] (Mus musculus)

phospho-p-S214,S582 ARAF [cytosol] (Plasmodium falciparum)

phospho-p-S214,S582 ARAF [cytosol] (Rattus norvegicus)

phospho-p-S214,S582 ARAF [cytosol] (Sus scrofa)

phospho-p-S214,S582 ARAF [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 214

Coordinate

214

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 582

Coordinate

582

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_011542210.1, NP_001243126.1, NP_001243125.1, NP_001645.1

Guide to Pharmacology - Targets

1933

OpenTargets

ENSG00000078061

ENSEMBL

ENST00000377039, ENSP00000366244, ENST00000377045, ENSP00000366238

ZINC - Substances

ARAF_HUMAN

ZINC target

P10398

PRO

P10398

GlyGen

P10398

PDB

1WXM, 2MSE, 9AXM

IntEnz

2.7.11.1

HPA

ENSG00000078061-ARAF

Pharos - Targets

P10398

HMDB Protein

HMDBP01219

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P36507 MAP2K2	12	p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073) MAP2K2 Y134C [cytosol] (R-HSA-9652089) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2(1-10) [cytosol] (R-HSA-5211334)	0.91	10
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.897	10
UniProt:Q02750 MAP2K1	20	MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67N [cytosol] (R-HSA-9652016) p-S218,S222-MAP2K1 [cytosol] (R-HSA-109837) MAP2K1 [cytosol] (R-HSA-59502) p-S218,S222,T286,T292-MAP2K1 [cytosol] (R-HSA-112339) p-T286,T292-MAP2K1 [cytosol] (R-HSA-112374) p-S,218, S222,T292 MAP2K1 [cytosol] (R-HSA-5674490) MAP2K1 F53C [cytosol] (R-HSA-9652028) MAP2K1 P124Q [cytosol] (R-HSA-9652058) MAP2K1 L42_K57del [cytosol] (R-HSA-9652026) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 F53L [cytosol] (R-HSA-9652031)	0.855	10
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.837	10
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.827	7
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.81	9
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.809	8
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.758	4
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.643	4
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.643	3
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.611	3
UniProt:Q8IXH7 NELFCD	1	NELFCD [nucleoplasm] (R-HSA-112428)	0.553	5
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.527	3
UniProt:Q92985 IRF7	5	IRF7 [cytosol] (R-HSA-450281) p-S477,S479-IRF7 [cytosol] (R-HSA-450318) p-S477,S479-IRF7 [nucleoplasm] (R-HSA-450270) IRF7 [endosome membrane] (R-HSA-450274) K63polyUb-IRF7 [endosome membrane] (R-HSA-975154)	0.499	2
UniProt:O43187 IRAK2	6	IRAK2 [endosome membrane] (R-HSA-975116) p-IRAK2 [endosome membrane] (R-HSA-975187) IRAK2 [plasma membrane] (R-HSA-937014) IRAK2 [cytosol] (R-HSA-772534) p-IRAK2 [plasma membrane] (R-HSA-936949) p-IRAK2 [cytosol] (R-HSA-446636)	0.499	2
UniProt:P58753 TIRAP	2	TIRAP [cytosol] (R-HSA-166141) p-4Y-TIRAP [plasma membrane] (R-HSA-2201321)	0.499	2
UniProt:P01116 KRAS	20	S-Farn-Me-PalmS KRAS [plasma membrane] (R-HSA-9674814) p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane] (R-HSA-9674821) KRAS A146T [plasma membrane] (R-HSA-9649623) KRAS K147E [plasma membrane] (R-HSA-9651169) KRAS K147T [plasma membrane] (R-HSA-9651180) KRAS V14G [plasma membrane] (R-HSA-9651295) KRAS K147N [plasma membrane] (R-HSA-9651177) KRAS A146V [plasma membrane] (R-HSA-9649626) KRAS A146S [plasma membrane] (R-HSA-9649621) KRAS A146P [plasma membrane] (R-HSA-9649617) KRAS P34R [plasma membrane] (R-HSA-9651276) KRAS P34L [plasma membrane] (R-HSA-9651269) KRAS G12A [plasma membrane] (R-HSA-9649088) KRAS G12R [plasma membrane] (R-HSA-9649090) KRAS G13V [plasma membrane] (R-HSA-9649644) KRAS G13S [plasma membrane] (R-HSA-9649642) KRAS G13C [plasma membrane] (R-HSA-9649636) KRAS G13R [plasma membrane] (R-HSA-9649639) KRAS G13A [plasma membrane] (R-HSA-9649632) KRAS K5N [plasma membrane] (R-HSA-9651361)	0.483	2

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