Reactome | p-S299,S302,T452,T455,S582 ARAF [cytosol]

p-S299,S302,T452,T455,S582 ARAF [cytosol]

Stable Identifier

R-HSA-5672646

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - MAP2K and MAPK activation (Homo sapiens)
        
        Dissociation of RAS:RAF complex (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Homo sapiens)
        
        WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Homo sapiens)
        
        activated RAF homo/heterodimer [cytosol] (Homo sapiens)
        
        activated RAF monomer [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Homo sapiens)
        
        activated RAF homo/heterodimer [cytosol] (Homo sapiens)
        
        activated RAF monomer [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
        
        p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        MAP2Ks phosphorylate MAPKs (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        RAF phosphorylates MAP2K dimer (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
        
        'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Homo sapiens)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Homo sapiens)
        
        WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Homo sapiens)
        
        activated RAF homo/heterodimer [cytosol] (Homo sapiens)
        
        activated RAF monomer [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        activated RAF homo/heterodimer [cytosol] (Homo sapiens)
        
        activated RAF monomer [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
      - Negative regulation of MAPK pathway (Homo sapiens)
        
        PEBP1 binds activated RAF1 (Homo sapiens)
        
        p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Homo sapiens)
        
        p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        PP2A dephosphorylates RAF1 (Homo sapiens)
        
        p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        p21RAS:GTP:p-S621 RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        PP5 dephosphorylates RAF1 S338 (Homo sapiens)
        
        p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
      - RAF activation (Homo sapiens)
        
        "Activator" RAF:YWHAB dimer binds RAS:GTP (Homo sapiens)
        
        'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
        
        'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        Phosphorylation of RAF (Homo sapiens)
        
        p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
        
        'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Homo sapiens)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
        
        'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
        
        'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        Raf dimer inhibitors bind RAF heterodimers (Homo sapiens)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
        
        'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)
        
        p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Homo sapiens)
        
        p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Homo sapiens)
        
        'activator' RAF:YWHAB dimer [cytosol] (Homo sapiens)
        
        'activator' RAFs [cytosol] (Homo sapiens)
        
        p-S299,S302,T452,T455,S582 ARAF [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P10398 ARAF

Gene Names

ARAF, ARAF1, PKS, PKS2

Chain

chain:1-606

Reference Genes

BioGPS Gene:369 ARAF

COSMIC (genes):ARAF ARAF

CTD Gene:369 ARAF

dbSNP Gene:369 ARAF

ENSEMBL:ENSG00000078061 ARAF

ENSEMBL_homo_sapiens_GENE:ENSG00000078061.14 ARAF

HGNC:646 ARAF

KEGG Gene (Homo sapiens):369 ARAF

Monarch:369 ARAF

NCBI Gene:369 ARAF

OMIM:311010 ARAF

UCSC:P10398 ARAF

Reference Transcript

Other Identifiers

11728747_s_at

11728748_x_at

11752388_a_at

11756111_a_at

11763195_at

1706_at

1707_g_at

17103160

201895_PM_at

201895_at

230652_PM_at

230652_at

369

3976302

3976309

3976310

3976312

3976313

3976315

3976317

3976318

3976319

3976320

3976322

3976323

3976324

3976327

3976328

3976331

3976332

3976334

3976335

3976337

3976338

3976339

3976340

58393_at

8167165

A_14_P110286

A_23_P73511

A_33_P3362353

GE79947

GO:0000165

GO:0000166

GO:0001934

GO:0003824

GO:0004672

GO:0004674

GO:0004709

GO:0005515

GO:0005524

GO:0005575

GO:0005739

GO:0005829

GO:0006468

GO:0007165

GO:0012501

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0030163

GO:0032006

GO:0032434

GO:0033138

GO:0036211

GO:0043066

GO:0043226

GO:0046872

GO:0106310

GO:0140096

GO:1902531

HMNXSV003053579

HMNXSV003056217

Hs.77183.1.A1_3p_at

M13829_s_at

PH_hs_0034517

TC0X000237.hg

TC0X001688.hg

U01337_at

g4502192_3p_at

g4502192_3p_x_at

p26937

Participates

as a candidate of

Other forms of this molecule

p-S299,S302,T452,T455,S582 ARAF [plasma membrane]

p-S582 ARAF [cytosol]

p-S214,S582 ARAF [cytosol]

Inferred To

phospho-p-S299,S302,T452,T455,S582 ARAF [cytosol] (Bos taurus)

phospho-p-S299,S302,T452,T455,S582 ARAF [cytosol] (Caenorhabditis elegans)

phospho-p-S299,S302,T452,T455,S582 ARAF [cytosol] (Danio rerio)

phospho-p-S299,S302,T452,T455,S582 ARAF [cytosol] (Drosophila melanogaster)

phospho-p-S299,S302,T452,T455,S582 ARAF [cytosol] (Mus musculus)

phospho-p-S299,S302,T452,T455,S582 ARAF [cytosol] (Plasmodium falciparum)

phospho-p-S299,S302,T452,T455,S582 ARAF [cytosol] (Rattus norvegicus)

phospho-p-S299,S302,T452,T455,S582 ARAF [cytosol] (Sus scrofa)

phospho-p-S299,S302,T452,T455,S582 ARAF [cytosol] (Xenopus tropicalis)

Homologues of p-S299,S302,T452,T455,S582 ARAF [cytosol] (Plasmodium falciparum)

phospho-ARAF [cytosol] (Canis familiaris)

Modified Residues

Name

O-phospho-L-serine at 582

Coordinate

582

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 299

Coordinate

299

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O4'-phospho-L-tyrosine at 302

Coordinate

302

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O-phospho-L-threonine at 452

Coordinate

452

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 455

Coordinate

455

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

XP_011542210.1, NP_001645.1, NP_001243126.1, NP_001243125.1

Guide to Pharmacology - Targets

1933

OpenTargets

ENSG00000078061

IntEnz

2.7.11.1

GeneCards

P10398

HPA

ENSG00000078061-ARAF

Ensembl

ENSG00000078061, ENSP00000366244, ENSP00000366238, ENST00000377045, ENST00000377039

ZINC target

P10398

PRO

P10398

Pharos - Targets

P10398

HMDB Protein

HMDBP01219

PDB

9AXM, 1WXM, 2MSE

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P36507 MAP2K2	12	MAP2K2(1-10) [cytosol] (R-HSA-5211334) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 Y134C [cytosol] (R-HSA-9652089) p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073)	0.91	10
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.897	10
UniProt:Q02750 MAP2K1	20	MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67N [cytosol] (R-HSA-9652016) MAP2K1 Q56P [cytosol] (R-HSA-9652064) MAP2K1 E203K [cytosol] (R-HSA-9652023) MAP2K1 V60E [cytosol] (R-HSA-9652067) MAP2K1 P124S [cytosol] (R-HSA-9652062) MAP2K1 Y130C [cytosol] (R-HSA-9652101) MAP2K1 C121S [cytosol] (R-HSA-9652013) MAP2K1 G128V [cytosol] (R-HSA-9652047) MAP2K1 F53L [cytosol] (R-HSA-9652031) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 L42_K57del [cytosol] (R-HSA-9652026)	0.855	10
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.837	10
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.827	7
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.81	9
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.809	8
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.758	4
UniProt:Q13451 FKBP5	2	FKBP5 [cytosol] (R-HSA-5618096) FKBP5 [nucleoplasm] (R-HSA-8939165)	0.643	3
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.643	4
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.611	3
UniProt:Q8IXH7 NELFCD	1	NELFCD [nucleoplasm] (R-HSA-112428)	0.553	5
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.527	3
UniProt:P58753 TIRAP	2	TIRAP [cytosol] (R-HSA-166141) p-4Y-TIRAP [plasma membrane] (R-HSA-2201321)	0.499	2
UniProt:Q92985 IRF7	5	K63polyUb-IRF7 [endosome membrane] (R-HSA-975154) IRF7 [endosome membrane] (R-HSA-450274) p-S477,S479-IRF7 [nucleoplasm] (R-HSA-450270) p-S477,S479-IRF7 [cytosol] (R-HSA-450318) IRF7 [cytosol] (R-HSA-450281)	0.499	2
UniProt:O43187 IRAK2	6	IRAK2 [endosome membrane] (R-HSA-975116) p-IRAK2 [endosome membrane] (R-HSA-975187) IRAK2 [plasma membrane] (R-HSA-937014) IRAK2 [cytosol] (R-HSA-772534) p-IRAK2 [plasma membrane] (R-HSA-936949) p-IRAK2 [cytosol] (R-HSA-446636)	0.499	2
UniProt:P01116 KRAS	20	S-Farn-Me-PalmS KRAS [plasma membrane] (R-HSA-9674814) p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane] (R-HSA-9674821) KRAS A146T [plasma membrane] (R-HSA-9649623) KRAS K147E [plasma membrane] (R-HSA-9651169) KRAS K147T [plasma membrane] (R-HSA-9651180) KRAS V14G [plasma membrane] (R-HSA-9651295) KRAS K147N [plasma membrane] (R-HSA-9651177) KRAS A146V [plasma membrane] (R-HSA-9649626) KRAS A146S [plasma membrane] (R-HSA-9649621) KRAS A146P [plasma membrane] (R-HSA-9649617) KRAS P34R [plasma membrane] (R-HSA-9651276) KRAS P34L [plasma membrane] (R-HSA-9651269) KRAS G12A [plasma membrane] (R-HSA-9649088) KRAS G12R [plasma membrane] (R-HSA-9649090) KRAS G13V [plasma membrane] (R-HSA-9649644) KRAS G13S [plasma membrane] (R-HSA-9649642) KRAS G13C [plasma membrane] (R-HSA-9649636) KRAS G13R [plasma membrane] (R-HSA-9649639) KRAS G13A [plasma membrane] (R-HSA-9649632) KRAS K5N [plasma membrane] (R-HSA-9651361)	0.483	2

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