Reactome | p-2S MAP2K homo/heterodimers [cytosol]

p-2S MAP2K homo/heterodimers [cytosol]

Stable Identifier

R-HSA-5672721

Type

Set [DefinedSet]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Participants

members

Participates

as an output of

as a component of

p-BRAF/RAF fusion dimers:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [cytosol] (Homo sapiens)
p-BRAF/RAF fusion dimers:p-2S MAP2Ks:MAPKs:scaffold proteins [cytosol] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
activated RAF1 mutant:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)
RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:p-T,Y MAPK complex [cytosol] (Homo sapiens)
high kinase activity BRAF mutants:scaffold:p-2S MAP2K:MAPK complex [cytosol] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Homo sapiens)
IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] (Homo sapiens)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Homo sapiens)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Homo sapiens)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Homo sapiens)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Homo sapiens)

as an input of

IL17RD binds p-2S MAP2Ks and MAPKs (Homo sapiens)

as a candidate of

RAF activating kinases [plasma membrane] (Homo sapiens)

Inferred To

p-2S MAP2K homo/heterodimers [cytosol] (Bos taurus)

p-2S MAP2K homo/heterodimers [cytosol] (Caenorhabditis elegans)

p-2S MAP2K homo/heterodimers [cytosol] (Danio rerio)

p-2S MAP2K homo/heterodimers [cytosol] (Dictyostelium discoideum)

p-2S MAP2K homo/heterodimers [cytosol] (Drosophila melanogaster)

p-2S MAP2K homo/heterodimers [cytosol] (Mus musculus)

p-2S MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)

p-2S MAP2K homo/heterodimers [cytosol] (Saccharomyces cerevisiae)

p-2S MAP2K homo/heterodimers [cytosol] (Schizosaccharomyces pombe)

p-S218,S222 MAP2K1 dimer [cytosol] (Gallus gallus)

p-S222,S226 MAP2K2 dimer [cytosol] (Canis familiaris)

p-S222,S226 MAP2K2 dimer [cytosol] (Sus scrofa)

© 2025 Reactome

Cite Us!