Reactome | Phosphorylated AKT1S1:mTORC1 binds YWHAB

Phosphorylated AKT1S1:mTORC1 binds YWHAB

Stable Identifier

R-HSA-5672824

Type

Reaction [binding]

Species

Homo sapiens

Compartment

lysosomal membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Phosphorylated AKT1S1:mTORC1 binds YWHAB

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

AKT1S1 (PRAS40) phosphorylation by AKT at Thr246, or at Ser183 by mTORC1, leads to the binding of YWHAB (14-3-3 beta) (Zhang et al. 2002, Kovacina et al. 2003, Oshiro et al. 2007). As AKT1S1 suppresses mTORC1 phosphorylation of physiological substrates S6K1 and 4E-BP1 (Oshiro et al. 2007) binding of YWHAB is proposed to relieve this inhibition (Wang et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
12151408	Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs Zhang, H, Zha, X, Tan, Y, Hornbeck, PV, Mastrangelo, AJ, Alessi, DR, Polakiewicz, RD, Comb, MJ	J. Biol. Chem.	2002