Reactome | Phosphorylated AKT1S1:mTORC1 binds YWHAB

Phosphorylated AKT1S1:mTORC1 binds YWHAB

Stable Identifier

R-HSA-5672824

Type

Reaction [binding]

Species

Homo sapiens

Compartment

lysosomal membrane, cytosol

ReviewStatus

5/5

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Phosphorylated AKT1S1:mTORC1 binds YWHAB

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AKT1S1 (PRAS40) phosphorylation by AKT at Thr246, or at Ser183 by mTORC1, leads to the binding of YWHAB (14-3-3 beta) (Zhang et al. 2002, Kovacina et al. 2003, Oshiro et al. 2007). As AKT1S1 suppresses mTORC1 phosphorylation of physiological substrates S6K1 and 4E-BP1 (Oshiro et al. 2007) binding of YWHAB is proposed to relieve this inhibition (Wang et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
12151408	Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs Zha, X, Hornbeck, PV, Polakiewicz, RD, Alessi, DR, Tan, Y, Comb, MJ, Mastrangelo, AJ, Zhang, H	J. Biol. Chem.	2002