YWHAB dimer dissociates from KSR1:MARK3

Stable Identifier
R-HSA-5672958
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Dephosphorylation of KSR1 S406 by PP2A promotes the dissociation of 14-3-3 from this site, exposing both the CR1 region that is required for membrane localization of KSR1 and the MAPK-binding FxFP motif (Ory et al, 2003; Muller et al, 2001; reviewed in Raabe and Raap, 2003).
Literature References
PubMed ID Title Journal Year
12932339 Ras signaling: PP2A puts Ksr and Raf in the right place

Raabe, T, Rapp, UR

Curr. Biol. 2003
11741534 C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1

Piwnica-Worms, H, Muller, J, Ory, S, Copeland, T, Morrison, DK

Mol Cell 2001
12932319 Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites

Veenstra, TD, Ory, S, Zhou, M, Morrison, DK, Conrads, TP

Curr Biol 2003
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