Reactome | MAP2Ks phosphorylate MAPKs

MAP2Ks phosphorylate MAPKs

Stable Identifier

R-HSA-5672973

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Activated MAP2K phosphorylates MAPK on threonine and tyrosine residues in the activation loop (residues T202 and Y204 in MAPK3, residues T185 and Y187 in MAPK1) (Ray et al, 1988; reviewed in Roskoski, 2012b). MAPK3 and MAPK1 are 84% identical and appear to be stimulated in parallel by all known activators of the MAPK pathway (Lefloch et al, 2009; reviewed in Lloyd, 2006).

Literature References

PubMed ID	Title	Journal	Year
3287375	Insulin-stimulated microtubule-associated protein kinase is phosphorylated on tyrosine and threonine in vivo Sturgill, TW, Ray, LB	Proc. Natl. Acad. Sci. U.S.A.	1988
16879721	Distinct functions for ERKs? Lloyd, AC	J. Biol.	2006
22569528	ERK1/2 MAP kinases: structure, function, and regulation Roskoski, R Jr	Pharmacol. Res.	2012
19242111	Total ERK1/2 activity regulates cell proliferation Pouysségur, J, Lefloch, R, Lenormand, P	Cell Cycle	2009