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hyperphosphorylated RAF1 [plasma membrane]
Stable Identifier
R-HSA-5675193
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p-S29,S43,S259,S296,S301,S338,Y341,T491,S494,S621,S642 RAF1, RAF proto-oncogene serine/threonine-protein kinase , Raf-1, C-RAF, cRaf
Icon
Locations in the PathwayBrowser for interactor UniProt:P50991 CCT4
Expand all
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
Negative feedback regulation of MAPK pathway (Homo sapiens)
Activated MAPK phosphorylates RAF1 (Homo sapiens)
hyperphosphorylated RAF1 [plasma membrane] (Homo sapiens)
PP2A dephosphorylates RAF1 (Homo sapiens)
hyperphosphorylated RAF1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04049 RAF1
Gene Names
RAF1, RAF
Chain
chain:1-648
Reference Genes
BioGPS Gene:5894 RAF1
COSMIC (genes):RAF1 RAF1
CTD Gene:5894 RAF1
dbSNP Gene:5894 RAF1
ENSEMBL:ENSG00000132155 RAF1
ENSEMBL_homo_sapiens_GENE:ENSG00000132155.14 RAF1
HGNC:9829 RAF1
KEGG Gene (Homo sapiens):5894 RAF1
Monarch:5894 RAF1
NCBI Gene:5894 RAF1
OMIM:164760 RAF1
UCSC:P04049 RAF1
Reference Transcript
RefSeq:NM_002880.3 RAF1
RefSeq:XM_011533974.2 RAF1
RefSeq:XM_005265355.2 RAF1
Other Identifiers
11716472_a_at
11748273_a_at
16950848
1917_at
201244_PM_s_at
201244_s_at
2663243
2663245
2663246
2663247
2663248
2663251
2663253
2663258
2663261
2663263
2663270
2663271
2663272
2663273
2663274
2663275
2663278
2663279
2663280
2663281
2663282
2663283
2663284
2663288
2663289
2663290
2663291
2663292
38742_s_at
38743_f_at
42597_at
5894
8085374
A_23_P40952
GO:0000165
GO:0000166
GO:0001678
GO:0001934
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004709
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005739
GO:0005741
GO:0005794
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0006915
GO:0007010
GO:0007165
GO:0007190
GO:0008285
GO:0008286
GO:0008625
GO:0012501
GO:0014044
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0019899
GO:0023052
GO:0030154
GO:0030878
GO:0031143
GO:0031267
GO:0031333
GO:0033138
GO:0035019
GO:0035023
GO:0035773
GO:0035994
GO:0036211
GO:0038133
GO:0042060
GO:0042552
GO:0042802
GO:0042981
GO:0043066
GO:0043154
GO:0043226
GO:0043410
GO:0044342
GO:0045104
GO:0045595
GO:0045944
GO:0046872
GO:0048009
GO:0048011
GO:0048538
GO:0048856
GO:0048870
GO:0060324
GO:0060333
GO:0065003
GO:0071550
GO:0098542
GO:0106310
GO:0140096
GO:1902042
GO:1902531
GO:2000145
HMNXSV003010706
HMNXSV003037375
ILMN_1813489
PH_hs_0039978
TC03001174.hg
X03484_at
g4506400_3p_a_at
Participates
as an output of
Activated MAPK phosphorylates RAF1 (Homo sapiens)
This entity regulates
Positively
PP2A dephosphorylates RAF1
(Homo sapiens)
Other forms of this molecule
p-S338,Y340,Y341-RAF1 [cytosol]
p-S338-RAF1 [cytosol]
p-S621-RAF1 S259F [cytosol]
p-S621-RAF1 S257L [cytosol]
p-S621-RAF1 P261L [cytosol]
p-S621-RAF1 N262K [cytosol]
p-S621-RAF1 P261A [cytosol]
p-S621-RAF1 P261S [cytosol]
p-S621-RAF1 S259T [cytosol]
p-S621-RAF1 P261T [cytosol]
p-S621-RAF1 P261R [cytosol]
p-S621-RAF1 S259P [cytosol]
p-S621-RAF1 T260I [cytosol]
p-S621-RAF1 T260R [cytosol]
p-S621-RAF1 V263A [cytosol]
p-S621-RAF1 R256S [cytosol]
p-S621-RAF1 T491I [cytosol]
p-S621-RAF1 D486N [cytosol]
p-S621-RAF1 S427G [cytosol]
p-S621-RAF1 L613V [cytosol]
p-S621-RAF1 G361A [cytosol]
p-S621-RAF1 G370R [cytosol]
p-S621-RAF1 D486G [cytosol]
p-S621-RAF1 T491R [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol]
p-S338,Y341,S494,S621-RAF1 T491I [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol]
p-S338,Y341,S494,S621 RAF1 T491R [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol]
p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol]
p-S621-RAF1 [plasma membrane]
p-Y341,T491,S494,S621 RAF1 [plasma membrane]
p-S259,S621-RAF1 [cytosol]
RAF1 [cytosol]
p-Y-RAF1 [cytosol]
p-S621-RAF1 [cytosol]
p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
Inferred To
Homologues of hyperphosphorylated RAF1 [plasma membrane]
(Plasmodium falciparum)
phospho-RAF1 [plasma membrane]
(Canis familiaris)
phospho-hyperphosphorylated RAF1 [plasma membrane]
(Caenorhabditis elegans)
phospho-hyperphosphorylated RAF1 [plasma membrane]
(Drosophila melanogaster)
phospho-hyperphosphorylated RAF1 [plasma membrane]
(Gallus gallus)
phospho-hyperphosphorylated RAF1 [plasma membrane]
(Mus musculus)
phospho-hyperphosphorylated RAF1 [plasma membrane]
(Plasmodium falciparum)
phospho-hyperphosphorylated RAF1 [plasma membrane]
(Rattus norvegicus)
phospho-hyperphosphorylated RAF1 [plasma membrane]
(Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 621
Coordinate
621
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O4'-phospho-L-tyrosine at 341
Coordinate
341
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O-phospho-L-serine at 338
Coordinate
338
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 491
Coordinate
491
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 494
Coordinate
494
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 29
Coordinate
29
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 43
Coordinate
43
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 259
Coordinate
259
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 296
Coordinate
296
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 301
Coordinate
301
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 642
Coordinate
642
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_002871.1
,
XP_011532276.1
,
XP_005265412.1
ZINC - World Drugs
RAF1_HUMAN
Guide to Pharmacology - Targets
2184
OpenTargets
ENSG00000132155
ZINC - FDA approved
RAF1_HUMAN
ZINC - Substances
RAF1_HUMAN
ZINC - Biogenic
RAF1_HUMAN
ZINC target
P04049
PRO
P04049
PDB
6XGU
,
6PTW
,
6NTC
,
8T75
,
7JHP
,
7Z38
,
8ATR
,
4FJ3
,
4G0N
,
8AV0
,
1GUA
,
6XHA
,
8CPD
,
6PTS
,
8GAE
,
8CHF
,
9AXA
,
4IEA
,
7Z37
,
8A6F
,
3KUC
,
3OMV
,
9AYA
,
6XI7
,
3NKX
,
8ATS
,
8GFT
,
1C1Y
,
3IQJ
,
8A6H
,
8A68
,
3IQV
,
8EPW
,
3CU8
,
4G3X
,
9AY7
,
6VJJ
,
6XGV
,
3KUD
,
3IQU
,
4IHL
,
6XHB
,
1RFA
,
6NTD
,
8T74
,
8U1L
,
1FAR
,
3O8I
,
1FAQ
,
9AXC
ZINC - Investigational
RAF1_HUMAN
HPA
ENSG00000132155-RAF1
GeneCards
P04049
Ensembl
ENST00000442415
,
ENSP00000509968
,
ENSP00000401888
,
ENST00000685653
,
ENST00000251849
,
ENST00000691899
,
ENSP00000251849
,
ENSP00000508763
,
ENSG00000132155
Pharos - Targets
P04049
Orphanet
16828
ZINC - Predictions - Purchasable
RAF1_HUMAN
HMDB Protein
HMDBP01153
Interactors (70)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01112 HRAS
20
HRAS Q61R [plasma membrane]
(R-HSA-6802458)
HRAS Q61L [plasma membrane]
(R-HSA-6802452)
HRAS Q61K [plasma membrane]
(R-HSA-6802442)
HRAS G13R [plasma membrane]
(R-HSA-6802368)
HRAS G12V [plasma membrane]
(R-HSA-6802350)
HRAS G12S [plasma membrane]
(R-HSA-6802343)
HRAS T58I [plasma membrane]
(R-HSA-9656014)
HRAS G13C [plasma membrane]
(R-HSA-9656008)
HRAS K117R [plasma membrane]
(R-HSA-9656010)
HRAS G13V [plasma membrane]
(R-HSA-9656579)
HRAS G13D [plasma membrane]
(R-HSA-9656572)
HRAS G13S [plasma membrane]
(R-HSA-9656574)
HRAS K117N [plasma membrane]
(R-HSA-9656603)
HRAS G12D [plasma membrane]
(R-HSA-9656564)
HRAS G12C [plasma membrane]
(R-HSA-9656561)
HRAS [plasma membrane]
(R-HSA-62717)
S-Farn-Me HRAS [plasma membrane]
(R-HSA-9665052)
S-Farn-Me PalmS HRAS [Golgi membrane]
(R-HSA-9647896)
S-Farn-Me HRAS [endoplasmic reticulum membrane]
(R-HSA-9647796)
S-Farn-HRAS [endoplasmic reticulum membrane]
(R-HSA-9647788)
0.978
30
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.966
35
UniProt:P15056 BRAF
20
BRAF(1-380)-MACF1(600-7388)fusion [cytosol]
(R-HSA-6802402)
p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol]
(R-HSA-6802536)
BRAF E501G [cytosol]
(R-HSA-9651132)
BRAF D594N [cytosol]
(R-HSA-6802299)
BRAF D638E [cytosol]
(R-HSA-9651125)
BRAF G596R [cytosol]
(R-HSA-6802385)
BRAF D594V [cytosol]
(R-HSA-6802305)
BRAF G596V [cytosol]
(R-HSA-9651138)
BRAF G466E [cytosol]
(R-HSA-6802374)
BRAF D594G [cytosol]
(R-HSA-6802295)
BRAF L505H [cytosol]
(R-HSA-9648845)
BRAF F595L [cytosol]
(R-HSA-6802316)
BRAF L597V [cytosol]
(R-HSA-6802397)
BRAF G464E [cytosol]
(R-HSA-6802369)
BRAF N581D [cytosol]
(R-HSA-9651152)
BRAF E586K [cytosol]
(R-HSA-6802308)
BRAF V600K [cytosol]
(R-HSA-6802502)
BRAF A246P [cytosol]
(R-HSA-9651123)
BRAF G469V [cytosol]
(R-HSA-9648620)
BRAF T244P [cytosol]
(R-HSA-9651165)
0.966
72
UniProt:Q02750 MAP2K1
20
MAP2K1(9-393) [cytosol]
(R-HSA-5211353)
MAP2K1(2-8) [cytosol]
(R-HSA-5211342)
MAP2K1 F53S [cytosol]
(R-HSA-9652034)
MAP2K1 D67N [cytosol]
(R-HSA-9652016)
MAP2K1 Q56P [cytosol]
(R-HSA-9652064)
MAP2K1 E203K [cytosol]
(R-HSA-9652023)
MAP2K1 V60E [cytosol]
(R-HSA-9652067)
MAP2K1 P124S [cytosol]
(R-HSA-9652062)
MAP2K1 Y130C [cytosol]
(R-HSA-9652101)
MAP2K1 C121S [cytosol]
(R-HSA-9652013)
MAP2K1 G128V [cytosol]
(R-HSA-9652047)
MAP2K1 F53L [cytosol]
(R-HSA-9652031)
MAP2K1 K57N [cytosol]
(R-HSA-9652050)
MAP2K1 K57T [cytosol]
(R-HSA-9652052)
MAP2K1 F53V [cytosol]
(R-HSA-9652038)
MAP2K1 D67Y [cytosol]
(R-HSA-9652019)
MAP2K1 G128D [cytosol]
(R-HSA-9652043)
MAP2K1 P124L [cytosol]
(R-HSA-9652056)
MAP2K1 F53Y [cytosol]
(R-HSA-9652041)
MAP2K1 L42_K57del [cytosol]
(R-HSA-9652026)
0.96
39
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.955
38
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.936
27
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.928
25
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.926
24
UniProt:P01111 NRAS
20
NRAS [tertiary granule membrane]
(R-HSA-6800190)
NRAS Q61H [plasma membrane]
(R-HSA-9649678)
NRAS G13R [plasma membrane]
(R-HSA-9649672)
NRAS G13V [plasma membrane]
(R-HSA-9649675)
NRAS G13C [plasma membrane]
(R-HSA-9649669)
NRAS G12V [plasma membrane]
(R-HSA-9649666)
NRAS G12C [plasma membrane]
(R-HSA-9649660)
NRAS G12R [plasma membrane]
(R-HSA-9649662)
NRAS G12A [plasma membrane]
(R-HSA-9649657)
NRAS Q61P [plasma membrane]
(R-HSA-9649680)
NRAS Q61R [plasma membrane]
(R-HSA-6802461)
NRAS Q61L [plasma membrane]
(R-HSA-6802455)
NRAS Q61K [plasma membrane]
(R-HSA-6802446)
NRAS G13D [plasma membrane]
(R-HSA-6802363)
NRAS G12S [plasma membrane]
(R-HSA-6802347)
NRAS G12D [plasma membrane]
(R-HSA-6802339)
NRAS Q60E [plasma membrane]
(R-HSA-9656589)
NRAS [plasma membrane]
(R-HSA-62725)
S-Farn-Me NRAS [plasma membrane]
(R-HSA-9647893)
S-Farn-Me PalmS NRAS [Golgi membrane]
(R-HSA-9647906)
0.925
12
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.913
24
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.899
20
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.887
9
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.857
17
UniProt:P36507 MAP2K2
12
MAP2K2(1-10) [cytosol]
(R-HSA-5211334)
MAP2K2(11-400) [cytosol]
(R-HSA-5211337)
MAP2K2 C125S [cytosol]
(R-HSA-9652070)
MAP2K2 P128Q [cytosol]
(R-HSA-9652082)
MAP2K2 V35M [cytosol]
(R-HSA-9652086)
MAP2K2 Y134C [cytosol]
(R-HSA-9652089)
p-S222,S226-MAP2K2 [cytosol]
(R-HSA-169292)
MAP2K2 [cytosol]
(R-HSA-59504)
p-S,T-MAP2K2 [cytosol]
(R-HSA-109848)
MAP2K2 N126D [cytosol]
(R-HSA-9652079)
MAP2K2 L46F [cytosol]
(R-HSA-9652076)
MAP2K2 F57C [cytosol]
(R-HSA-9652073)
0.85
7
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.811
6
UniProt:P30086 PEBP1
1
PEBP1 [cytosol]
(R-HSA-61487)
0.758
10
UniProt:P07900 HSP90AA1
8
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
HSP90AA1 [lysosomal lumen]
(R-HSA-9622850)
0.744
15
UniProt:Q3ZCQ8 TIMM50
1
TIMM50 [mitochondrial inner membrane]
(R-HSA-1252070)
0.738
7
UniProt:P01116 KRAS
20
S-Farn-Me-PalmS KRAS [plasma membrane]
(R-HSA-9674814)
p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane]
(R-HSA-9674821)
KRAS A146T [plasma membrane]
(R-HSA-9649623)
KRAS K147E [plasma membrane]
(R-HSA-9651169)
KRAS K147T [plasma membrane]
(R-HSA-9651180)
KRAS V14G [plasma membrane]
(R-HSA-9651295)
KRAS K147N [plasma membrane]
(R-HSA-9651177)
KRAS A146V [plasma membrane]
(R-HSA-9649626)
KRAS A146S [plasma membrane]
(R-HSA-9649621)
KRAS A146P [plasma membrane]
(R-HSA-9649617)
KRAS P34R [plasma membrane]
(R-HSA-9651276)
KRAS P34L [plasma membrane]
(R-HSA-9651269)
KRAS G12A [plasma membrane]
(R-HSA-9649088)
KRAS G12R [plasma membrane]
(R-HSA-9649090)
KRAS G13V [plasma membrane]
(R-HSA-9649644)
KRAS G13S [plasma membrane]
(R-HSA-9649642)
KRAS G13C [plasma membrane]
(R-HSA-9649636)
KRAS G13R [plasma membrane]
(R-HSA-9649639)
KRAS G13A [plasma membrane]
(R-HSA-9649632)
KRAS K5N [plasma membrane]
(R-HSA-9651361)
0.695
6
UniProt:P01116-2 KRAS
8
S-Farn-Me KRAS4B [cytosol]
(R-HSA-9654510)
pS181-S-Farn-Me KRAS4B [mitochondrial outer membrane]
(R-HSA-9653578)
pS181-S-Farn-Me KRAS4B [plasma membrane]
(R-HSA-9653482)
S-Farn-Me KRAS4B [endoplasmic reticulum membrane]
(R-HSA-9649690)
S-Farn KRAS4B [endoplasmic reticulum membrane]
(R-HSA-9649698)
S-Farn proKRAS4B [endoplasmic reticulum membrane]
(R-HSA-9649693)
pro-KRAS4B [cytosol]
(R-HSA-9649686)
S-Farn-Me KRAS4B [plasma membrane]
(R-HSA-9647815)
0.676
3
UniProt:O95816 BAG2
1
BAG2 [cytosol]
(R-HSA-5255445)
0.669
12
UniProt:P49368 CCT3
1
CCT3 [cytosol]
(R-HSA-390463)
0.659
8
UniProt:Q13188 STK3
4
p-T180-STK3(1-322) [cytosol]
(R-HSA-2028696)
STK3(323-491) [cytosol]
(R-HSA-2028684)
STK3(1-491) [cytosol]
(R-HSA-2028280)
p-T180-STK3(1-491) [cytosol]
(R-HSA-2028274)
0.645
6
UniProt:O43852 CALU
3
CALU [endoplasmic reticulum lumen]
(R-HSA-350695)
p-CALU [endoplasmic reticulum lumen]
(R-HSA-8956931)
CALU [extracellular region]
(R-HSA-350739)
0.643
4
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.643
3
UniProt:P50990 CCT8
5
CCT8 [secretory granule lumen]
(R-HSA-6801035)
CCT8 [ficolin-1-rich granule lumen]
(R-HSA-6800894)
CCT8 [extracellular region]
(R-HSA-6806238)
CCT8 [azurophil granule lumen]
(R-HSA-6799369)
CCT8 [cytosol]
(R-HSA-390449)
0.643
7
UniProt:P10398 ARAF
4
p-S299,S302,T452,T455,S582 ARAF [cytosol]
(R-HSA-5672646)
p-S299,S302,T452,T455,S582 ARAF [plasma membrane]
(R-HSA-5672648)
p-S582 ARAF [cytosol]
(R-HSA-5672681)
p-S214,S582 ARAF [cytosol]
(R-HSA-5672639)
0.643
4
UniProt:P62834 RAP1A
4
RAP1A [plasma membrane]
(R-HSA-354118)
RAP1A [endosome membrane]
(R-HSA-190053)
RAP1A [cytosol]
(R-HSA-169884)
RAP1A [specific granule membrane]
(R-HSA-6806137)
0.623
2
UniProt:Q96S96 PEBP4
0.597
4
UniProt:P11021 HSPA5
6
HSPA5 [extracellular region]
(R-HSA-351322)
HSPA5 [endoplasmic reticulum lumen]
(R-HSA-387190)
HSPA5 [endoplasmic reticulum membrane]
(R-HSA-351315)
HSPA5 [cytosol]
(R-HSA-5252115)
HSPA5 [nucleoplasm]
(R-HSA-5252042)
HSPA5 [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985498)
0.576
5
UniProt:Q6TCH7 PAQR3
1
PAQR3 [Golgi membrane]
(R-HSA-5674103)
0.576
3
UniProt:P32883 Kras
17
phospho-p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane]
(R-MMU-9674821)
Kras [plasma membrane]
(R-MMU-1250483)
S-Farn-Me KRAS4A [plasma membrane]
(R-MMU-9647811)
S-Farn-Me KRAS4B [cytosol]
(R-MMU-9654510)
phospho-pS181-S-Farn-Me KRAS4B [plasma membrane]
(R-MMU-9653482)
phospho-pS181-S-Farn-Me KRAS4B [mitochondrial outer membrane]
(R-MMU-9653578)
S-Farn-Me PalmS KRAS4A [Golgi membrane]
(R-MMU-9647903)
proKRAS [cytosol]
(R-MMU-9647762)
pro-KRAS4A [cytosol]
(R-MMU-9649683)
S-Farn proKRAS4B [endoplasmic reticulum membrane]
(R-MMU-9649693)
S-Farn-proKRAS [endoplasmic reticulum membrane]
(R-MMU-9647925)
S-Farn-Me KRAS [endoplasmic reticulum membrane]
(R-MMU-9647801)
S-Farn KRAS4B [endoplasmic reticulum membrane]
(R-MMU-9649698)
S-Farn-KRAS [endoplasmic reticulum membrane]
(R-MMU-9647790)
S-Farn-Me KRAS4B [endoplasmic reticulum membrane]
(R-MMU-9649690)
S-Farn-Me-PalmS KRAS4A [plasma membrane]
(R-MMU-9647915)
S-Farn-Me KRAS4B [plasma membrane]
(R-MMU-9647815)
0.573
2
UniProt:Q8IVT5 KSR1
5
p-S311,S406 KSR1 [cytosol]
(R-HSA-5672654)
KSR1 [cytosol]
(R-HSA-5672587)
p-S311 KSR1 [cytosol]
(R-HSA-5672652)
p-S311,Y602 KSR1 [plasma membrane]
(R-HSA-5672659)
p-S311,Y602 KSR1 [cytosol]
(R-HSA-5672656)
0.564
5
UniProt:Q9UNE7 STUB1
1
STUB1 [cytosol]
(R-HSA-975970)
0.564
8
UniProt:Q15773 MLF2
0.564
4
UniProt:Q13526 PIN1
2
PIN1 [cytosol]
(R-HSA-9626823)
PIN1 [nucleoplasm]
(R-HSA-936016)
0.564
2
UniProt:Q13177 PAK2
11
p-S141,T402-PAK2 [plasma membrane]
(R-HSA-5096524)
PAK2(1-524) [plasma membrane]
(R-HSA-164946)
p-Y130,S141,T402-PAK2 [cytosol]
(R-HSA-5218705)
K48polyUb-p-T402-PAK-2p43 [cytosol]
(R-HSA-3095873)
p-T402-PAK2(213-524) [nucleoplasm]
(R-HSA-211709)
p-T402-PAK2(213-524) [cytosol]
(R-HSA-211654)
p-5S-PAK2(2-212) [cytosol]
(R-HSA-211588)
p-S141,T402-PAK2 [cytosol]
(R-HSA-399824)
PAK2 [cytosol]
(R-HSA-211604)
p-5S-PAK2 [cytosol]
(R-HSA-211609)
PAK2(213-524) [cytosol]
(R-HSA-211653)
0.558
2
UniProt:Q14790 CASP8
8
CASP8(1-374) [cytosol]
(R-HSA-3465404)
CASP8(217-374) [mitochondrial outer membrane]
(R-HSA-351869)
CASP8(385-479) [mitochondrial outer membrane]
(R-HSA-351828)
CASP8(385-479) [cytosol]
(R-HSA-76158)
CASP8(375-384) [cytosol]
(R-HSA-933460)
CASP8(217-374) [cytosol]
(R-HSA-75975)
CASP8(1-216) [cytosol]
(R-HSA-933456)
CASP8(1-479) [cytosol]
(R-HSA-57031)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:O39474 O39474
0.556
4
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:Q13362 PPP2R5C
3
PPP2R5C [nucleoplasm]
(R-HSA-3008946)
p-S337-PPP2R5C [cytosol]
(R-HSA-6811447)
PPP2R5C [cytosol]
(R-HSA-3008954)
0.544
2
UniProt:P67775 PPP2CA
4
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
PPP2CA [nucleoplasm]
(R-HSA-165978)
PPP2CA [cytosol]
(R-HSA-165971)
0.544
2
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.536
2
UniProt:P78371 CCT2
3
CCT2 [extracellular region]
(R-HSA-6806220)
CCT2 [azurophil granule lumen]
(R-HSA-6799356)
CCT2 [cytosol]
(R-HSA-390464)
0.527
6
UniProt:Q99832 CCT7
1
CCT7 [cytosol]
(R-HSA-390451)
0.527
6
UniProt:P30876 POLR2B
1
POLR2B [nucleoplasm]
(R-HSA-63504)
0.527
2
UniProt:P50991 CCT4
1
CCT4 [cytosol]
(R-HSA-390458)
0.527
6
UniProt:P17066 HSPA6
5
HSPA6 [cytosol]
(R-HSA-3371521)
HSPA6 [nucleoplasm]
(R-HSA-5252088)
HSPA6 [secretory granule lumen]
(R-HSA-6801472)
HSPA6 [extracellular region]
(R-HSA-6806500)
HSPA6 [ficolin-1-rich granule lumen]
(R-HSA-6801512)
0.527
3
UniProt:Q9ULX6 AKAP8L
1
AKAP8L [nucleoplasm]
(R-HSA-9821364)
0.527
9
UniProt:P61619 SEC61A1
2
SEC61A1 [endoplasmic reticulum membrane]
(R-HSA-444591)
SEC61A1 [phagocytic vesicle membrane]
(R-HSA-1236813)
0.527
3
UniProt:Q9H9S3 SEC61A2
2
SEC61A2 [endoplasmic reticulum membrane]
(R-HSA-444585)
SEC61A2 [phagocytic vesicle membrane]
(R-HSA-1236771)
0.527
3
UniProt:Q96AG4 LRC59
0.527
2
UniProt:P50402 EMD
4
EMD [nuclear envelope]
(R-HSA-201573)
EMD [cytosol]
(R-HSA-9613988)
EMD [endoplasmic reticulum membrane]
(R-HSA-9613998)
EMD [endosome membrane]
(R-HSA-9715092)
0.527
2
UniProt:P48643 CCT5
1
CCT5 [cytosol]
(R-HSA-390447)
0.527
6
UniProt:O14593 RFXK
0.527
3
UniProt:Q58FF7 H90B3
0.527
13
UniProt:P40227 CCT6A
1
CCT6A [cytosol]
(R-HSA-390454)
0.527
6
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.527
5
UniProt:Q8N163 CCAR2
2
DBC1 [nucleoplasm]
(R-HSA-3371479)
p-T454-DBC1 [nucleoplasm]
(R-HSA-3371569)
0.527
9
UniProt:Q53GQ0 HSD17B12
1
HSD17B12 [endoplasmic reticulum membrane]
(R-HSA-548766)
0.527
2
UniProt:O43324 EEF1E1
1
EEF1E1 [cytosol]
(R-HSA-379693)
0.527
2
UniProt:P03495 NS1
0.508
2
UniProt:Q99933 BAG1
1
BAG1 [cytosol]
(R-HSA-5255443)
0.508
2
UniProt:O15371 EIF3D
1
EIF3D [cytosol]
(R-HSA-72548)
0.508
4
UniProt:P43246 MSH2
3
MSH2 R406* [nucleoplasm]
(R-HSA-5575594)
MSH2 [nucleoplasm]
(R-HSA-5357525)
MSH2 GLN601TER [nucleoplasm]
(R-HSA-5577243)
0.508
2
UniProt:P28301
3
LOX(22-168) [extracellular region]
(R-MMU-2022074)
LOX(22-417) [extracellular region]
(R-MMU-2022071)
LOX [extracellular region]
(R-MMU-2022085)
0.499
2
UniProt:Q9ESN9-2 MAPK8IP3
0.499
2
UniProt:P01120
2
RRAS2 [plasma membrane]
(R-SCE-9715189)
RRAS [plasma membrane]
(R-SCE-396959)
0.499
2
UniProt:P05783 KRT18
1
KRT18 [cytosol]
(R-HSA-201582)
0.488
5
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