BRAF is subject to MAPK-dependent phosphorylation that limits its activity. Phosphorylation of S151 inhibits binding of BRAF to activated RAS, while phosphorylation of T401, S750 and S753 abrogates heterodimerization with RAF1 (Ritt et al, 2010; Rushworth et al, 2006; Brummer et al, 2003).
O'Neill, E, Rushworth, LK, Hindley, AD, Kolch, W
Brummer, T, Naegele, H, Misawa, Y, Reth, M
Specht, SI, Monson, DM, Morrison, DK, Ritt, DA
protein serine/threonine kinase activity of p-T,Y MAPK monomers and dimers [cytosol]
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