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DUSP9 [cytosol]
Stable Identifier
R-HSA-5675351
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Signaling by MAPK mutants (Homo sapiens)
Constitutively active MAPK1 mutants are not dephosphorylated by DUSPs (Homo sapiens)
cytosolic MAPK DUSPs [cytosol] (Homo sapiens)
DUSP9 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF-independent MAPK1/3 activation (Homo sapiens)
Cytosolic DUSPs dephosphorylate MAPKs (Homo sapiens)
cytosolic MAPK DUSPs [cytosol] (Homo sapiens)
DUSP9 [cytosol] (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
Cytosolic DUSPs dephosphorylate MAPKs (Homo sapiens)
cytosolic MAPK DUSPs [cytosol] (Homo sapiens)
DUSP9 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99956 DUSP9
Gene Names
DUSP9, MKP4
Chain
chain:1-384
Reference Genes
BioGPS Gene:1852 DUSP9
COSMIC (genes):DUSP9 DUSP9
CTD Gene:1852 DUSP9
dbSNP Gene:1852 DUSP9
ENSEMBL:ENSG00000130829 DUSP9
HGNC:3076 DUSP9
KEGG:hsa:1852 DUSP9
Monarch:1852 DUSP9
NCBI Gene:1852 DUSP9
OMIM:300134 DUSP9
UCSC:Q99956 DUSP9
Reference Transcript
RefSeq:NM_001395.3 DUSP9
RefSeq:XM_011531124.1 DUSP9
RefSeq:NM_001318503.1 DUSP9
Other Identifiers
11731750_s_at
11755621_x_at
1443_at
17108056
1852
205777_PM_at
205777_at
3995773
3995777
3995778
3995779
3995780
3995781
3995782
3995783
3995784
3995785
3995786
3995787
3995788
3995789
40186_at
8170695
A_14_P109655
A_24_P417189
GE60251
GO:0000165
GO:0003824
GO:0004721
GO:0004722
GO:0004725
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006470
GO:0007254
GO:0008138
GO:0008330
GO:0016311
GO:0016787
GO:0017017
GO:0017018
GO:0033550
GO:0043226
GO:0043409
GO:0070371
GO:0140096
HMNXSV003043390
ILMN_1712314
PH_hs_0008587
TC0X000753.hg
TC0X001927.hg
Y08302_at
g4503420_3p_at
Participates
as a member of
cytosolic MAPK DUSPs [cytosol] (Homo sapiens)
Inferred To
Homologues of DUSP9 [cytosol]
(Caenorhabditis elegans)
Homologues of DUSP9 [cytosol]
(Dictyostelium discoideum)
mpl1 [cytosol]
(Dictyostelium discoideum)
Dusp9 [cytosol]
(Mus musculus)
Dusp9 [cytosol]
(Rattus norvegicus)
DUSP9 [cytosol]
(Bos taurus)
DUSP9 [cytosol]
(Caenorhabditis elegans)
DUSP9 [cytosol]
(Canis familiaris)
DUSP9 [cytosol]
(Dictyostelium discoideum)
DUSP9 [cytosol]
(Plasmodium falciparum)
DUSP9 [cytosol]
(Sus scrofa)
Mkp3 [cytosol]
(Drosophila melanogaster)
lip-1 [cytosol]
(Caenorhabditis elegans)
mpl2 [cytosol]
(Dictyostelium discoideum)
dusp9 [cytosol]
(Xenopus tropicalis)
mpl3 [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_001386.1
,
NP_001305432.1
,
XP_011529426.1
ENSEMBL
ENSP00000359186
,
ENST00000370167
,
ENST00000342782
,
ENSP00000345853
OpenTargets
ENSG00000130829
HPA
ENSG00000130829-DUSP9
PRO
Q99956
Pharos - Targets
Q99956
HMDB Protein
HMDBP08916
PDB
3LJ8
,
2HXP
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16539 MAPK14
7
MAPK14 [ficolin-1-rich granule lumen]
(R-HSA-6803280)
MAPK14 [extracellular region]
(R-HSA-6806453)
MAPK14 [secretory granule lumen]
(R-HSA-6803300)
MAPK14 [nucleoplasm]
(R-HSA-446223)
MAPK14 [cytosol]
(R-HSA-428933)
p-T180,Y182-MAPK14 [cytosol]
(R-HSA-428935)
p-T180,Y182-MAPK14 [nucleoplasm]
(R-HSA-446227)
0.779
6
UniProt:P28482 MAPK1
18
p-T185,Y187-MAPK1 [nucleoplasm]
(R-HSA-112354)
p-T185,Y187-MAPK1 [cytosol]
(R-HSA-109853)
MAPK1 [cytosol]
(R-HSA-59282)
MAPK1 [nucleoplasm]
(R-HSA-199960)
p-T185-MAPK1 [cytosol]
(R-HSA-9635773)
p-T185,Y187 MAPK1 P58G [cytosol]
(R-HSA-9652802)
p-T185,Y187 MAPK1 E322A [cytosol]
(R-HSA-9652794)
p-T185,Y187 MAPK1 D321N [cytosol]
(R-HSA-9652785)
p-T185,Y187 MAPK1 D321V [cytosol]
(R-HSA-9652791)
p-T185,Y187 MAPK1 P58L [cytosol]
(R-HSA-9652806)
p-T185,Y187 MAPK1 S142L [cytosol]
(R-HSA-9652808)
p-T185,Y187 MAPK1 E81K [cytosol]
(R-HSA-9652799)
p-T185,Y187 MAPK1 E322K [cytosol]
(R-HSA-9652175)
p-T185,Y187 MAPK1 E322V [cytosol]
(R-HSA-9652797)
MAPK1 [azurophil granule lumen]
(R-HSA-6799225)
MAPK1 [extracellular region]
(R-HSA-6806250)
MAPK1 [ficolin-1-rich granule lumen]
(R-HSA-6800964)
MAPK1 [endoplasmic reticulum lumen]
(R-HSA-9636293)
0.738
5
UniProt:P27361 MAPK3
6
p-T202,Y204-MAPK3 [nucleoplasm]
(R-HSA-112359)
p-T202,Y204-MAPK3 [cytosol]
(R-HSA-109842)
MAPK3 [cytosol]
(R-HSA-59284)
MAPK3 [nucleoplasm]
(R-HSA-73724)
p-T202-MAPK3 [cytosol]
(R-HSA-9635775)
MAPK3 [endoplasmic reticulum lumen]
(R-HSA-9636295)
0.615
3
UniProt:P47811 Mapk14
7
p-T180,Y182-Mapk14 [nucleoplasm]
(R-MMU-1605486)
phospho-MAP kinase p38 alpha [cytosol]
(R-MMU-448842)
MAP kinase p38 alpha [cytosol]
(R-MMU-448843)
MAPK14 [nucleoplasm]
(R-MMU-446223)
MAPK14 [secretory granule lumen]
(R-MMU-6803300)
MAPK14 [extracellular region]
(R-MMU-6806453)
MAPK14 [ficolin-1-rich granule lumen]
(R-MMU-6803280)
0.527
2
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