Reactome | Cytosolic DUSPs dephosphorylate MAPKs

Cytosolic DUSPs dephosphorylate MAPKs

Stable Identifier

R-HSA-5675376

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

MAPKs are inactivated by dephosphorylation of the activation loop T and Y residues by dual-specificity MAPK phosphatases (DUSPs) (reviewed in Roskoski, 2012b). Cytosolic MAPKs are dephosphorylated by the MAPK-specific class II DUSPs 6,7 and 9, but may also be dephosphorylated by cytosolic forms of class III DUSPs 8, 10 and 16, which preferentially dephosphorylate p38 and JNK MAP kinases (reviewed in Bermudez et al, 2010; Kandoh and Nishida, 2007).

Literature References

PubMed ID	Title	Journal	Year
17208316	Regulation of MAP kinases by MAP kinase phosphatases Kondoh, K, Nishida, E	Biochim. Biophys. Acta	2007
20463170	The dual-specificity MAP kinase phosphatases: critical roles in development and cancer Gimond, C, Pagès, G, Bermudez, O	Am. J. Physiol., Cell Physiol.	2010
22569528	ERK1/2 MAP kinases: structure, function, and regulation Roskoski, R Jr	Pharmacol. Res.	2012