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K48pUb-BIRC2 [cytosol]
Stable Identifier
R-HSA-5675479
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
K48polyUB-BIRC, K48polyUb-cIAP2
Icon
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Regulated Necrosis (Homo sapiens)
RIPK1-mediated regulated necrosis (Homo sapiens)
Regulation of necroptotic cell death (Homo sapiens)
BIRC2/3 (cIAP1/2) is autoubiquitinated (Homo sapiens)
K48pUb- BIRC2,3,4 [cytosol] (Homo sapiens)
K48pUb-BIRC2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13490 BIRC2
Gene Names
BIRC2, API1, MIHB, RNF48
Chain
chain:1-618
Reference Genes
BioGPS Gene:329 BIRC2
COSMIC (genes):BIRC2 BIRC2
CTD Gene:329 BIRC2
dbSNP Gene:329 BIRC2
ENSEMBL:ENSG00000110330 BIRC2
ENSEMBL_homo_sapiens_GENE:ENSG00000110330.10 BIRC2
HGNC:590 BIRC2
KEGG Gene (Homo sapiens):329 BIRC2
Monarch:329 BIRC2
NCBI Gene:329 BIRC2
OMIM:601712 BIRC2
UCSC:Q13490 BIRC2
Reference Transcript
RefSeq:NM_001256166.1 BIRC2
RefSeq:NM_001166.4 BIRC2
RefSeq:NM_001256163.1 BIRC2
Other Identifiers
11717627_a_at
11717628_a_at
11744694_a_at
11750887_a_at
11757937_s_at
16730540
202076_PM_at
202076_at
329
3346585
3346586
3346587
3346588
3346589
3346590
3346593
3346594
3346595
3346596
3346597
3346598
3346599
3346601
3346604
3346605
3346607
3346608
3346609
3346610
3346611
3346612
3346613
3346614
3346615
3346616
36578_at
7943424
A_14_P124015
A_14_P129741
A_14_P131109
A_24_P115774
GE59117
GO:0000209
GO:0001666
GO:0001741
GO:0001890
GO:0002376
GO:0003713
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005694
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006915
GO:0006954
GO:0007166
GO:0007249
GO:0008270
GO:0009898
GO:0010243
GO:0012501
GO:0014070
GO:0016740
GO:0023052
GO:0030154
GO:0030163
GO:0031398
GO:0032991
GO:0033209
GO:0034121
GO:0035631
GO:0036211
GO:0038061
GO:0039535
GO:0042127
GO:0042802
GO:0042981
GO:0043027
GO:0043066
GO:0043123
GO:0043130
GO:0043161
GO:0043226
GO:0044877
GO:0045088
GO:0045471
GO:0045595
GO:0045893
GO:0046872
GO:0048856
GO:0050727
GO:0051087
GO:0051591
GO:0051726
GO:0060544
GO:0060546
GO:0061630
GO:0065003
GO:0070266
GO:0070424
GO:0071356
GO:0098542
GO:0098770
GO:0098772
GO:0140096
GO:0140110
GO:1901222
GO:1902443
GO:1902523
GO:1902524
GO:1902527
GO:1902916
GO:2000116
GO:2000377
HMNXSV003027101
ILMN_1768194
ILMN_2182704
PH_hs_0015035
TC11000957.hg
U37547_at
g10880127_3p_at
Participates
as a member of
K48pUb- BIRC2,3,4 [cytosol] (Homo sapiens)
Other forms of this molecule
K63polyUb-BIRC2 [cytosol]
BIRC2(1-372) [cytosol]
BIRC2(373-618) [cytosol]
BIRC2 [cytosol]
Inferred To
birc2 [cytosol]
(Danio rerio)
birc2 [cytosol]
(Xenopus tropicalis)
K48pUb-BIRC2 [cytosol]
(Drosophila melanogaster)
K48pUb-BIRC2 [cytosol]
(Gallus gallus)
K48pUb-BIRC2 [cytosol]
(Mus musculus)
K48pUb-BIRC2 [cytosol]
(Schizosaccharomyces pombe)
BIRC2 [cytosol]
(Bos taurus)
BIRC2 [cytosol]
(Canis familiaris)
BIRC2 [cytosol]
(Sus scrofa)
Birc2 [cytosol]
(Rattus norvegicus)
Modified Residues
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_001157.1
,
NP_001243092.1
,
NP_001243095.1
Guide to Pharmacology - Targets
2791
OpenTargets
ENSG00000110330
ZINC - Substances
BIRC2_HUMAN
ZINC target
Q13490
PRO
Q13490
PDB
4LGE
,
7TRM
,
6HPR
,
4KMN
,
4EB9
,
3D9T
,
3T6P
,
7TRL
,
8DSO
,
5M6N
,
6W74
,
3UW4
,
3MUP
,
3OZ1
,
4MU7
,
6EXW
,
6W8I
,
8DSF
,
7QGJ
,
2L9M
,
4MTI
,
6W7O
,
4HY5
,
3M1D
,
3D9U
,
4HY4
,
1QBH
,
4LGU
ZINC - Investigational
BIRC2_HUMAN
HPA
ENSG00000110330-BIRC2
GeneCards
Q13490
Ensembl
ENSG00000110330
,
ENSP00000431723
,
ENST00000530675
,
ENST00000613397
,
ENST00000227758
,
ENSP00000227758
,
ENSP00000477613
Pharos - Targets
Q13490
ZINC - Predictions - Purchasable
BIRC2_HUMAN
Interactors (69)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.951
19
UniProt:P55211 CASP9
5
p-S196-CASP9(1-416) [cytosol]
(R-HSA-198636)
p-T412-CASP9(1-416) [cytosol]
(R-HSA-9627087)
CASP9(331-416) [cytosol]
(R-HSA-141639)
CASP9(?-315) [cytosol]
(R-HSA-141638)
CASP9(1-416) [cytosol]
(R-HSA-57033)
0.919
12
UniProt:Q9NR28 DIABLO
2
DIABLO [mitochondrial intermembrane space]
(R-HSA-64637)
DIABLO [cytosol]
(R-HSA-114298)
0.825
8
UniProt:Q96HA8 NTAQ1
0.801
8
UniProt:Q96CA5 BIRC7
1
BIRC7 [cytosol]
(R-HSA-50855)
0.801
8
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.798
8
UniProt:P01375 TNF
5
TNF(52-76) [extracellular region]
(R-HSA-8863375)
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-233) [plasma membrane]
(R-HSA-66220)
0.788
5
UniProt:Q9Y3E2 BOLA1
0.781
7
UniProt:Q92844 TANK
2
TANK [cytosol]
(R-HSA-933407)
K63polyUb-TANK [cytosol]
(R-HSA-5362480)
0.725
5
UniProt:Q96CN9 GCC1
1
GCC1 [cytosol]
(R-HSA-6813877)
0.718
6
UniProt:P08949-2 NMB
0.718
6
UniProt:Q8N3J5 PPM1K
2
H139Hfs13* PPM1K [mitochondrial matrix]
(R-HSA-9912515)
PPM1K [mitochondrial matrix]
(R-HSA-5693145)
0.718
6
UniProt:Q9NQT4 EXOSC5
2
EXOSC5 [cytosol]
(R-HSA-429889)
EXOSC5 [nucleoplasm]
(R-HSA-6791550)
0.718
6
UniProt:Q13546 RIPK1
20
K48polyUb-RIPK1 [cytosol]
(R-HSA-6783308)
PolyUb-RIPK1 [cytosol]
(R-HSA-6783197)
RIPK1 D324N [cytosol]
(R-HSA-9693930)
RIPK1 D324Y [cytosol]
(R-HSA-9693931)
RIPK1 D324V [cytosol]
(R-HSA-9693927)
RIPK1 D324H [cytosol]
(R-HSA-9693922)
RIPK1 [plasma membrane]
(R-HSA-937073)
K48polyUb-K571,K604,K627-RIPK1 [cytosol]
(R-HSA-9796639)
K63,Met1polyUb-p-S25-RIPK1 [cytosol]
(R-HSA-9818793)
K63,M1polyUb-RIPK1 [cytosol]
(R-HSA-9793681)
RIPK1(1-324) [cytosol]
(R-HSA-5212664)
RIPK1(325-671) [cytosol]
(R-HSA-5212671)
polyUb-K377,K604,K634-RIPK1 [cytosol]
(R-HSA-9818391)
K63,M1polyUb, p-T189-RIPK1 [cytosol]
(R-HSA-9817377)
p-S320-RIPK1 [cytosol]
(R-HSA-9815498)
p-S357-RIPK1 [cytosol]
(R-HSA-9819116)
p-S166-RIPK1 [cytosol]
(R-HSA-5218872)
K63polyUb-RIPK1 [cytosol]
(R-HSA-937021)
RIPK1 [endosome membrane]
(R-HSA-450326)
RIPK1 [cytosol]
(R-HSA-168651)
0.697
5
UniProt:P19438 TNFRSF1A
2
TNFRSF1A(41-201) [extracellular region]
(R-HSA-6785048)
TNFRSF1A(30-45) [plasma membrane]
(R-HSA-5675738)
0.69
4
UniProt:Q13490 BIRC2
5
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
BIRC2 [cytosol]
(R-HSA-50847)
0.667
4
UniProt:Q9BZW7 TSG10
0.666
4
UniProt:O43464 HTRA2
1
HTRA2 [mitochondrial intermembrane space]
(R-HSA-56655)
0.65
4
UniProt:P55210 CASP7
5
CASP7(24-198) [nucleoplasm]
(R-HSA-351927)
CASP7(207-303) [nucleoplasm]
(R-HSA-351924)
CASP7(2-303) [cytosol]
(R-HSA-57029)
CASP7(24-198) [cytosol]
(R-HSA-141641)
CASP7(207-303) [cytosol]
(R-HSA-141642)
0.641
3
ChEBI:47924 N,N'-(HEXANE-1,6-DIYL)BIS(1-{(2S)-2-CYCLOHEXYL-2-[(N-METHYL-L-ALANYL)AMINO]ACETYL}-L-PROLYL-BETA-PHENYL-L-PHENYLALANINAMIDE)
0.618
4
ChEBI:47922 METHYL 1-{(2S)-2-CYCLOHEXYL-2-[(N-METHYL-L-ALANYL)AMINO]ACETYL}-L-PROLYL-BETA-PHENYL-L-PHENYLALANINATE
0.618
6
UniProt:P57078 RIPK4
0.602
3
UniProt:Q9Y572 RIPK3
8
p-S199,227, K48pUb-363-RIPK3 [cytosol]
(R-HSA-9686933)
K33polyUb-K197,302,364-RIPK3 [cytosol]
(R-HSA-9794180)
OGlcNAc-T467-RIPK3 [cytosol]
(R-HSA-9687819)
RIPK3(329-518) [cytosol]
(R-HSA-9686937)
RIPK3(1-328) [cytosol]
(R-HSA-9686917)
RIPK3 [cytosol]
(R-HSA-450328)
p-S199,227-RIPK3 [cytosol]
(R-HSA-5218873)
Ub-K55,363-RIPK3 [cytosol]
(R-HSA-9688825)
0.602
3
UniProt:O43353 RIPK2
2
RIPK2 [cytosol]
(R-HSA-168402)
Ub-209-RIPK2 [cytosol]
(R-HSA-706483)
0.602
3
UniProt:Q9UBU9 NXF1
2
NXF1 [cytosol]
(R-HSA-156481)
NXF1 [nucleoplasm]
(R-HSA-111690)
0.556
3
UniProt:P40325 HUA1
0.556
3
UniProt:A0A087WZT3 A0A087WZT3
0.556
3
UniProt:P32502
1
GCD7 [cytosol]
(R-SCE-72519)
0.556
3
UniProt:P51813 BMX
3
BMX(1-242) [cytosol]
(R-HSA-351899)
BMX [cytosol]
(R-HSA-351917)
BMX(243-675) [cytosol]
(R-HSA-351875)
0.556
3
UniProt:P08949 NMB
1
NMB(47-56) [extracellular region]
(R-HSA-375361)
0.556
3
UniProt:Q06455-2 RUNX1T1
0.556
3
UniProt:P51451 BLK
2
MyrG2-BLK [plasma membrane]
(R-HSA-9606871)
BLK [cytosol]
(R-HSA-983580)
0.556
3
UniProt:O60341 KDM1A
1
KDM1A [nucleoplasm]
(R-HSA-996769)
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:Q01976
1
NUDT5 [cytosol]
(R-SCE-2393933)
0.556
3
UniProt:P38339
2
RGD1 [cytosol]
(R-SCE-8873920-2)
RGD1 [cytosol]
(R-SCE-2976016-2)
0.556
3
UniProt:Q3E793 BOL1
0.556
3
UniProt:P40937 RFC5
1
RFC5 [nucleoplasm]
(R-HSA-68427)
0.556
3
UniProt:Q8WXH2 JPH3
0.556
3
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.556
3
UniProt:Q9Y4C2-2 TCAF1
0.556
3
UniProt:Q96CJ1 EAF2
1
EAF2 [nucleoplasm]
(R-HSA-8932790)
0.556
3
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:O75173 ADAMTS4
4
ADAMTS4 [extracellular region]
(R-HSA-2533998)
ADAMTS4 [endoplasmic reticulum lumen]
(R-HSA-5173253)
glc-fuc-ADAMTS4 [endoplasmic reticulum lumen]
(R-HSA-5172994)
O-fuc-ADAMTS4 [endoplasmic reticulum lumen]
(R-HSA-5173144)
0.527
3
UniProt:Q9NYW3 TAS2R7
1
TAS2R7 [plasma membrane]
(R-HSA-3299612)
0.527
2
UniProt:Q9H0L4 CSTF2T
1
CSTF2T [nucleoplasm]
(R-HSA-8938786)
0.527
2
UniProt:P19086 GNAZ
2
p-S27-GNAZ [plasma membrane]
(R-HSA-804942)
GNAZ [plasma membrane]
(R-HSA-167416)
0.527
2
UniProt:P00736 C1R
3
C1R(18-705) [extracellular region]
(R-HSA-173554)
C1R N-terminal fragment [extracellular region]
(R-HSA-173606)
C1R C-terminal fragment [extracellular region]
(R-HSA-173603)
0.527
3
UniProt:Q9Y240 CLC11
0.527
3
UniProt:P36941 LTBR
1
LTBR [plasma membrane]
(R-HSA-5668750)
0.527
3
UniProt:P30048 PRDX3
1
PRDX3 [mitochondrial matrix]
(R-HSA-3323081)
0.527
2
UniProt:Q5T6F0 DCA12
0.527
4
UniProt:Q9BQK8 LPIN3
3
p-S106-LPIN3 [nucleoplasm]
(R-HSA-4419935)
LPIN3 [nuclear envelope]
(R-HSA-4419928)
LPIN3 [endoplasmic reticulum membrane]
(R-HSA-549160)
0.527
3
UniProt:Q96EP0 RNF31
1
RNF31 [cytosol]
(R-HSA-5212660)
0.527
3
UniProt:Q9NQ34 TMM9B
0.527
2
UniProt:O75351 VPS4B
1
VPS4B [cytosol]
(R-HSA-917719)
0.527
2
UniProt:Q86SG7 LYG2
0.527
3
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.527
3
UniProt:Q13114 TRAF3
4
TRAF3 R118W [cytosol]
(R-HSA-5602321)
K48polyUb-TRAF3 [cytosol]
(R-HSA-936556)
TRAF3 [cytosol]
(R-HSA-914241)
K63polyUb-TRAF3 [cytosol]
(R-HSA-936402)
0.527
3
UniProt:O75325 LRRN2
0.527
2
UniProt:P58062 ISK7
0.527
2
UniProt:Q14790 CASP8
8
CASP8(1-374) [cytosol]
(R-HSA-3465404)
CASP8(217-374) [mitochondrial outer membrane]
(R-HSA-351869)
CASP8(385-479) [mitochondrial outer membrane]
(R-HSA-351828)
CASP8(385-479) [cytosol]
(R-HSA-76158)
CASP8(375-384) [cytosol]
(R-HSA-933460)
CASP8(217-374) [cytosol]
(R-HSA-75975)
CASP8(1-216) [cytosol]
(R-HSA-933456)
CASP8(1-479) [cytosol]
(R-HSA-57031)
0.527
2
UniProt:P26842 CD27
1
CD27 [plasma membrane]
(R-HSA-5666994)
0.527
2
UniProt:P17677 GAP43
2
PALM-C3,4-GAP43 [plasma membrane]
(R-HSA-8933482)
GAP43 [plasma membrane]
(R-HSA-452888)
0.527
2
UniProt:P21580 TNFAIP3
1
TNFAIP3 [cytosol]
(R-HSA-688989)
0.527
2
UniProt:P98170 XIAP
3
XIAP [nucleoplasm]
(R-HSA-3322366)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [cytosol]
(R-HSA-50849)
0.527
3
UniProt:P63000 RAC1
6
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
RAC1 [cytosol]
(R-HSA-442615)
RAC1 [plasma membrane]
(R-HSA-351141)
0.525
2
UniProt:Q96FW1 OTUB1
2
OTUB1 [cytosol]
(R-HSA-933411)
OTUB1 [nucleoplasm]
(R-HSA-6783242)
0.499
3
UniProt:Q9NP84 TNFRSF12A
1
TNFRSF12A [plasma membrane]
(R-HSA-5675666)
0.499
2
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