Regulation of necroptotic cell death

Stable Identifier
R-HSA-5675482
Type
Pathway
Species
Homo sapiens
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A regulated balance between cell survival and cell death is essential for normal development and homeostasis of multicellular organisms. Defects in control of this balance may contribute to autoimmune disease, neurodegeneration, ischemia/reperfusion injury, non alcoholic steatohepatitis (NASH) and cancer.

Literature References
PubMed ID Title Journal Year
18570872 cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

Morris, SJ, Milutinovic, S, Gillard, JW, Durkin, J, Ho, WC, Dickson, KM, Boudreault, A, Barker, PA, Bertrand, MJ, Jaquith, JB

Mol. Cell 2008
21737330 cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

Langlais, C, Geserick, P, Kellert, B, H├Ącker, G, Cain, K, Feoktistova, M, Hupe, M, MacFarlane, M, Leverkus, M, Dimitrova, DP

Mol. Cell 2011
29930286 Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

Sandow, JJ, Lessene, G, Kersten, WJA, Wardak, A, Tanzer, MC, Dai, W, Webb, AI, Hildebrand, JM, Young, SN, Silke, J, Jacobsen, AV, Smith, BJ, Cowan, AD, Liang, LY, Murphy, JM, Petrie, EJ, Lucet, IS, Czabotar, PE, Griffin, MDW

Nat Commun 2018
15701649 c-FLIPR, a new regulator of death receptor-induced apoptosis

Golks, A, Fritsch, C, Brenner, D, Lavrik, IN, Krammer, PH

J. Biol. Chem. 2005
12110583 c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis

Yaish-Ohad, S, Algeciras-Schimnich, A, Pan, Y, Chang, DW, Peter, ME, Xing, Z, Yang, X, Barnhart, BC

EMBO J. 2002
20218968 c-FLIP is involved in erythropoietin-mediated protection of erythroid-differentiated cells from TNF-alpha-induced apoptosis

Chamorro, ME, Vittori, D, Nesse, A, Vota, D, Callero, M

Cell Biol. Int. 2010
18621737 c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation

Dynek, JN, Deshayes, K, Fairbrother, WJ, Vucic, D, Goncharov, T, Varfolomeev, E, Fedorova, AV, Zobel, K

J. Biol. Chem. 2008
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