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EDARADD [cytosol]
Stable Identifier
R-HSA-5675659
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Ectodysplasin-A receptor-associated adapter protein, EDAD_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
TNFs bind their physiological receptors (Homo sapiens)
EDA:EDAR binds EDARADD (Homo sapiens)
EDA:EDAR:EDARADD [plasma membrane] (Homo sapiens)
EDARADD [cytosol] (Homo sapiens)
EDARADD [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8WWZ3 EDARADD
Gene Names
EDARADD
Chain
chain:1-215
Reference Genes
BioGPS Gene:128178 EDARADD
COSMIC (genes):EDARADD EDARADD
CTD Gene:128178 EDARADD
dbSNP Gene:128178 EDARADD
ENSEMBL:ENSG00000186197 EDARADD
ENSEMBL_homo_sapiens_GENE:ENSG00000186197.15 EDARADD
HGNC:14341 EDARADD
KEGG Gene (Homo sapiens):128178 EDARADD
Monarch:128178 EDARADD
NCBI Gene:128178 EDARADD
OMIM:606603 EDARADD
UCSC:Q8WWZ3 EDARADD
Reference Transcript
RefSeq:NM_145861.2 EDARADD
RefSeq:NM_080738.3 EDARADD
Other Identifiers
11728640_s_at
11733212_a_at
11741217_a_at
11741218_a_at
11741219_x_at
128178
1553430_PM_a_at
1553430_a_at
16679020
2386832
2386833
2386835
2386836
2386837
2386838
2386841
2386842
2386844
2386851
2386858
2386859
2386860
2386861
2386862
2386863
2386864
2386865
2386866
2395500
2395506
2395512
2395522
2395524
7910694
A_14_P130611
A_23_P503233
GE514624
GO:0005515
GO:0005737
GO:0005829
GO:0007165
GO:0023052
GO:0030154
HMNXSV003010997
Hs2.352224.2.S1_3p_a_at
ILMN_1719206
ILMN_1754592
ILMN_1761820
PH_hs_0028214
TC01001953.hg
Participates
as a component of
EDA:EDAR:EDARADD [plasma membrane] (Homo sapiens)
as an input of
EDA:EDAR binds EDARADD (Homo sapiens)
Inferred To
EDARADD [cytosol]
(Bos taurus)
EDARADD [cytosol]
(Canis familiaris)
EDARADD [cytosol]
(Gallus gallus)
EDARADD [cytosol]
(Sus scrofa)
Edaradd [cytosol]
(Mus musculus)
Edaradd [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_665860.2
,
NP_542776.1
OpenTargets
ENSG00000186197
HPA
ENSG00000186197-EDARADD
GeneCards
Q8WWZ3
Ensembl
ENST00000334232
,
ENST00000359362
,
ENSP00000335076
,
ENSP00000352320
,
ENSG00000186197
PRO
Q8WWZ3
Pharos - Targets
Q8WWZ3
Orphanet
15910
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96HA8 NTAQ1
0.666
4
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.556
5
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [cytosol]
(R-HSA-373639)
0.556
3
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
0.556
5
UniProt:P63279 UBE2I
9
monoSUMO1-K14-UBE2I [nucleoplasm]
(R-HSA-4085358)
UBE2I [nuclear envelope]
(R-HSA-4655408)
SUMO2-C93-UBE2I [cytosol]
(R-HSA-4656944)
SUMO3-C93-UBE2I [nucleoplasm]
(R-HSA-3730629)
UBE2I [cytosol]
(R-HSA-4655342)
SUMO1-C93-UBE2I [cytosol]
(R-HSA-4656909)
SUMO2-C93-UBE2I [nucleoplasm]
(R-HSA-3730619)
SUMO1-C93-UBE2I [nucleoplasm]
(R-HSA-3730617)
UBE2I [nucleoplasm]
(R-HSA-912481)
0.556
3
UniProt:G2XKQ0 SUMO5
0.556
5
UniProt:Q149N8 SHPRH
1
SHPRH [nucleoplasm]
(R-HSA-5689010)
0.556
3
UniProt:P63165 SUMO1
11
lysyl-G97-SUMO1 [plasma membrane]
(R-HSA-9762382)
lysyl-G97-SUMO1 [nucleolus]
(R-HSA-9762385)
lysyl-G97-SUMO1 [viral capsid]
(R-HSA-9762386)
UBE2I-G97-SUMO1 [cytosol]
(R-HSA-4656941)
lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9762380)
lysyl-G97-SUMO1 [cytosol]
(R-HSA-9762266)
UBE2I-G97-SUMO1 [nucleoplasm]
(R-HSA-3730622)
UBA2-G97-SUMO1 [nucleoplasm]
(R-HSA-3730616)
SUMO1 [nucleoplasm]
(R-HSA-877304)
SUMO1(2-101) [nucleoplasm]
(R-HSA-2990831)
lysyl-G97-SUMO1 [nucleoplasm]
(R-HSA-9761562)
0.556
5
UniProt:Q6ZNA4 RNF111
2
RNF111 [cytosol]
(R-HSA-975981)
RNF111 [nucleoplasm]
(R-HSA-2186765)
0.556
3
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