Reactome | TNFRSF12A [plasma membrane]

TNFRSF12A [plasma membrane]

Stable Identifier

R-HSA-5675666

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Tumor necrosis factor receptor superfamily member 12A, TNR12_HUMAN, FN14

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9NP84 TNFRSF12A

Gene Names

TNFRSF12A, FN14

Chain

signal peptide:1-27, chain:28-129

Reference Genes

BioGPS Gene:51330 TNFRSF12A

COSMIC (genes):TNFRSF12A TNFRSF12A

CTD Gene:51330 TNFRSF12A

dbSNP Gene:51330 TNFRSF12A

ENSEMBL:ENSG00000006327 TNFRSF12A

HGNC:18152 TNFRSF12A

KEGG:hsa:51330 TNFRSF12A

Monarch:51330 TNFRSF12A

NCBI Gene:51330 TNFRSF12A

OMIM:605914 TNFRSF12A

UCSC:Q9NP84 TNFRSF12A

Reference Transcript

RefSeq:NM_016639.2 TNFRSF12A

Other Identifiers

11745020_a_at

16815310

218368_PM_s_at

218368_s_at

3645556

3645557

3645558

3645559

3645560

3645561

3645562

3645563

3645564

48013_at

51330

7992789

A_14_P113491

A_14_P200410

A_23_P49338

GE53883

GE564227

GO:0001525

GO:0005515

GO:0005886

GO:0006915

GO:0007155

GO:0012501

GO:0016020

GO:0030154

GO:0043065

GO:0061041

GO:2001238

HMNXSV003056107

ILMN_1689004

TC16000095.hg

g7706185_3p_a_at

Participates

as an input of

TWEAK binds FN14 (Homo sapiens)

as a component of

3xFN14:sTWEAK,TWEAK homotrimer [plasma membrane] (Homo sapiens)

Inferred To

Tnfrsf12a [plasma membrane] (Mus musculus)

Tnfrsf12a [plasma membrane] (Rattus norvegicus)

TNFRSF12A [plasma membrane] (Bos taurus)

TNFRSF12A [plasma membrane] (Canis familiaris)

TNFRSF12A [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_057723.1

Guide to Pharmacology - Targets

1884

ENSEMBL

ENST00000341627, ENSP00000326737, ENST00000326577, ENSP00000343894

OpenTargets

ENSG00000006327

HPA

ENSG00000006327-TNFRSF12A

PRO

Q9NP84

Pharos - Targets

Q9NP84

PDB

2RPJ, 2EQP, 2KMZ

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BRI3 SLC30A2	2	SLC30A2 [endosome membrane] (R-HSA-435363) SLC30A2 [synaptic vesicle membrane] (R-HSA-4084714)	0.781	9
UniProt:O43508 TNFSF12	2	TNFSF12 [plasma membrane] (R-HSA-5667154) sTNFSF12 [extracellular region] (R-HSA-5675974)	0.558	2
UniProt:Q9BYR6 KRTAP3-3	1	KRTAP3-3 [cytosol] (R-HSA-6809859)	0.556	3
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.499	2
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.499	3