Reactome | TNFRSF1A(30-45) [plasma membrane]

TNFRSF1A(30-45) [plasma membrane]

Stable Identifier

R-HSA-5675738

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Tumor necrosis factor receptor superfamily member 1A, TNR1A_HUMAN

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External Reference Information

External Reference

UniProt:P19438 TNFRSF1A

Gene Names

TNFRSF1A, TNFAR, TNFR1

Chain

signal peptide:1-29, chain:30-455, chain:41-201

Reference Genes

BioGPS Gene:7132 TNFRSF1A

COSMIC (genes):TNFRSF1A TNFRSF1A

CTD Gene:7132 TNFRSF1A

dbSNP Gene:7132 TNFRSF1A

ENSEMBL:ENSG00000067182 TNFRSF1A

ENSEMBL_homo_sapiens_GENE:ENSG00000067182.9 TNFRSF1A

HGNC:11916 TNFRSF1A

KEGG Gene (Homo sapiens):7132 TNFRSF1A

Monarch:7132 TNFRSF1A

NCBI Gene:7132 TNFRSF1A

OMIM:191190 TNFRSF1A

UCSC:P19438 TNFRSF1A

Reference Transcript

Other Identifiers

11739346_s_at

11752814_s_at

11754297_s_at

1563_s_at

16760329

207643_PM_s_at

207643_s_at

3441848

3441850

3441851

3441852

3441853

3441854

3441855

3441856

3441857

3441858

3441859

3441860

3441861

3441863

3441864

3441865

3441867

3441868

3441869

3441871

3441878

3441879

7132

7960518

A_23_P139722

GE59806

GO:0000139

GO:0002947

GO:0003012

GO:0003176

GO:0003177

GO:0003332

GO:0005031

GO:0005515

GO:0005576

GO:0005615

GO:0005794

GO:0005886

GO:0006351

GO:0006355

GO:0006366

GO:0006629

GO:0006693

GO:0006915

GO:0006952

GO:0006954

GO:0007165

GO:0007166

GO:0008625

GO:0008630

GO:0009986

GO:0010614

GO:0010803

GO:0012501

GO:0016020

GO:0019221

GO:0023052

GO:0030154

GO:0030198

GO:0033209

GO:0034250

GO:0036211

GO:0038023

GO:0042531

GO:0042742

GO:0043120

GO:0043123

GO:0043226

GO:0043235

GO:0045121

GO:0045834

GO:0045944

GO:0048856

GO:0050728

GO:0050729

GO:0060089

GO:0071260

GO:0072659

GO:0098542

GO:1900119

GO:1902339

GO:1903140

GO:1905038

HMNXSV003033824

ILMN_1685005

M58286_s_at

PH_hs_0027516

TC12001135.hg

g4507574_3p_a_at

Participates

as a member of

TNFRSF1A,1B,14 [plasma membrane] (Homo sapiens)

as a component of

Other forms of this molecule

TNFRSF1A(41-201) [extracellular region]

Inferred To

TNFRSF1A [plasma membrane] (Bos taurus)

TNFRSF1A [plasma membrane] (Canis familiaris)

TNFRSF1A [plasma membrane] (Sus scrofa)

Tnfrsf1a [plasma membrane] (Rattus norvegicus)

TNFRSF1A(30-45) [plasma membrane] (Mus musculus)

tnfrsf1a [plasma membrane] (Danio rerio)

tnfrsf1a [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001333021.1, NP_001056.1, NP_001333020.1

Guide to Pharmacology - Targets

1870

OpenTargets

ENSG00000067182

ZINC - Substances

TNR1A_HUMAN

ZINC - Biogenic

TNR1A_HUMAN

ZINC target

P19438

PRO

P19438

PDB

1EXT, 7KP8, 7KPB, 1TNR, 1NCF, 7K7A, 1ICH, 7KP7, 1FT4, 8P6Q

HPA

ENSG00000067182-TNFRSF1A

GeneCards

P19438

Ensembl

ENSP00000513672, ENST00000698340, ENSG00000067182, ENST00000162749, ENSP00000513670, ENSP00000513671, ENST00000698339, ENSP00000162749, ENST00000437813

Pharos - Targets

P19438

ZINC - Predictions - Purchasable

TNR1A_HUMAN

Orphanet

15636

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15628 TRADD	1	TRADD [cytosol] (R-HSA-66376)	0.957	16
UniProt:P01375 TNF	5	TNF(52-76) [extracellular region] (R-HSA-8863375) TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-233) [plasma membrane] (R-HSA-66220)	0.939	16
UniProt:Q13546 RIPK1	20	K48polyUb-RIPK1 [cytosol] (R-HSA-6783308) PolyUb-RIPK1 [cytosol] (R-HSA-6783197) RIPK1 D324N [cytosol] (R-HSA-9693930) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 [plasma membrane] (R-HSA-937073) K48polyUb-K571,K604,K627-RIPK1 [cytosol] (R-HSA-9796639) K63,Met1polyUb-p-S25-RIPK1 [cytosol] (R-HSA-9818793) K63,M1polyUb-RIPK1 [cytosol] (R-HSA-9793681) RIPK1(1-324) [cytosol] (R-HSA-5212664) RIPK1(325-671) [cytosol] (R-HSA-5212671) polyUb-K377,K604,K634-RIPK1 [cytosol] (R-HSA-9818391) K63,M1polyUb, p-T189-RIPK1 [cytosol] (R-HSA-9817377) p-S320-RIPK1 [cytosol] (R-HSA-9815498) p-S357-RIPK1 [cytosol] (R-HSA-9819116) p-S166-RIPK1 [cytosol] (R-HSA-5218872) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) RIPK1 [endosome membrane] (R-HSA-450326) RIPK1 [cytosol] (R-HSA-168651)	0.877	7
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.745	5
UniProt:Q13490 BIRC2	5	K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(1-372) [cytosol] (R-HSA-202913) BIRC2(373-618) [cytosol] (R-HSA-202931) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2 [cytosol] (R-HSA-50847)	0.69	4
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.564	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2

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