Reactome | sTNFSF12 [extracellular region]

sTNFSF12 [extracellular region]

Stable Identifier

R-HSA-5675974

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Tumor necrosis factor ligand superfamily member 12, TNF12_HUMAN, soluble TNFSF12, sTWEAK

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - TNFR2 non-canonical NF-kB pathway (Homo sapiens)
    - K63polyUb-cIAP1,2 ubiquitinates TRAF3 (Homo sapiens)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        3xFN14:sTWEAK,TWEAK homotrimer [plasma membrane] (Homo sapiens)
        
        sTWEAK,TWEAK homotrimers [plasma membrane] (Homo sapiens)
        
        sTWEAK trimer [extracellular region] (Homo sapiens)
        
        sTNFSF12 [extracellular region] (Homo sapiens)
      - TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        3xFN14:sTWEAK,TWEAK homotrimer [plasma membrane] (Homo sapiens)
        
        sTWEAK,TWEAK homotrimers [plasma membrane] (Homo sapiens)
        
        sTWEAK trimer [extracellular region] (Homo sapiens)
        
        sTNFSF12 [extracellular region] (Homo sapiens)
    - Protesomal degradation of K48polyUb-TRAF3 (Homo sapiens)
      - TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        3xFN14:sTWEAK,TWEAK homotrimer [plasma membrane] (Homo sapiens)
        
        sTWEAK,TWEAK homotrimers [plasma membrane] (Homo sapiens)
        
        sTWEAK trimer [extracellular region] (Homo sapiens)
        
        sTNFSF12 [extracellular region] (Homo sapiens)
      - TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        3xFN14:sTWEAK,TWEAK homotrimer [plasma membrane] (Homo sapiens)
        
        sTWEAK,TWEAK homotrimers [plasma membrane] (Homo sapiens)
        
        sTWEAK trimer [extracellular region] (Homo sapiens)
        
        sTNFSF12 [extracellular region] (Homo sapiens)
    - TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway (Homo sapiens)
      - TRAF2:cIAP1/2 complex binds FN14:TWEAK (Homo sapiens)
        
        3xFN14:sTWEAK,TWEAK homotrimer [plasma membrane] (Homo sapiens)
        
        sTWEAK,TWEAK homotrimers [plasma membrane] (Homo sapiens)
        
        sTWEAK trimer [extracellular region] (Homo sapiens)
        
        sTNFSF12 [extracellular region] (Homo sapiens)
        
        3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        3xFN14:sTWEAK,TWEAK homotrimer [plasma membrane] (Homo sapiens)
        
        sTWEAK,TWEAK homotrimers [plasma membrane] (Homo sapiens)
        
        sTWEAK trimer [extracellular region] (Homo sapiens)
        
        sTNFSF12 [extracellular region] (Homo sapiens)
      - TWEAK binds FN14 (Homo sapiens)
        
        3xFN14:sTWEAK,TWEAK homotrimer [plasma membrane] (Homo sapiens)
        
        sTWEAK,TWEAK homotrimers [plasma membrane] (Homo sapiens)
        
        sTWEAK trimer [extracellular region] (Homo sapiens)
        
        sTNFSF12 [extracellular region] (Homo sapiens)
        
        sTWEAK,TWEAK homotrimers [plasma membrane] (Homo sapiens)
        
        sTWEAK trimer [extracellular region] (Homo sapiens)
        
        sTNFSF12 [extracellular region] (Homo sapiens)
    - TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK (Homo sapiens)
      - Non-canonical NF-kB initiating TNFRSF memebers [plasma membrane] (Homo sapiens)
        
        3xFn14:TWEAK:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        3xFN14:sTWEAK,TWEAK homotrimer [plasma membrane] (Homo sapiens)
        
        sTWEAK,TWEAK homotrimers [plasma membrane] (Homo sapiens)
        
        sTWEAK trimer [extracellular region] (Homo sapiens)
        
        sTNFSF12 [extracellular region] (Homo sapiens)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        3xFN14:sTWEAK,TWEAK homotrimer [plasma membrane] (Homo sapiens)
        
        sTWEAK,TWEAK homotrimers [plasma membrane] (Homo sapiens)
        
        sTWEAK trimer [extracellular region] (Homo sapiens)
        
        sTNFSF12 [extracellular region] (Homo sapiens)
    - cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK (Homo sapiens)
      - TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane] (Homo sapiens)
        
        TNFA:TNFR2,BAFF:BAFFR,TWEAK:Fn14,Lymphotoxin:LTBR,RANKL:RANK,CD40L:CD40 [plasma membrane] (Homo sapiens)
        
        3xFN14:sTWEAK,TWEAK homotrimer [plasma membrane] (Homo sapiens)
        
        sTWEAK,TWEAK homotrimers [plasma membrane] (Homo sapiens)
        
        sTWEAK trimer [extracellular region] (Homo sapiens)
        
        sTNFSF12 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43508 TNFSF12

Gene Names

TNFSF12, APO3L, DR3LG, UNQ181/PRO207

Chain

chain:1-249, chain:94-249

Reference Genes

BioGPS Gene:407977 TNFSF12

BioGPS Gene:8742 TNFSF12

COSMIC (genes):TNFSF12 TNFSF12

CTD Gene:8742 TNFSF12

dbSNP Gene:407977 TNFSF12

dbSNP Gene:8742 TNFSF12

ENSEMBL:ENSG00000239697 TNFSF12

ENSEMBL:ENSG00000239697.12 TNFSF12

HGNC:11927 TNFSF12

KEGG Gene (Homo sapiens):407977 TNFSF12

KEGG Gene (Homo sapiens):8742 TNFSF12

Monarch:407977 TNFSF12

Monarch:8742 TNFSF12

NCBI Gene:407977 TNFSF12

NCBI Gene:8742 TNFSF12

OMIM:602695 TNFSF12

Reference Transcript

Other Identifiers

11719911_at

205611_PM_at

205611_at

3708765

3708766

3708767

3708769

3708770

3708771

3708774

3708775

3708776

3708777

3708778

3708779

39588_at

8004464

8742

A_14_P133055

A_24_P245298

A_33_P3406623

GE54528

GO:0001525

GO:0001938

GO:0002376

GO:0005102

GO:0005125

GO:0005164

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0006915

GO:0006955

GO:0007154

GO:0007165

GO:0012501

GO:0016020

GO:0023052

GO:0030154

GO:0030163

GO:0043542

GO:0045732

GO:0045766

GO:0048018

GO:0048471

GO:0048856

GO:0048870

GO:0097191

GO:0098772

GO:2001238

HMNXSV003058400

ILMN_1683700

TC17002035.hg

TC17002864.hg

g4507596_3p_at

Participates

as a component of

sTWEAK trimer [extracellular region] (Homo sapiens)

Other forms of this molecule

TNFSF12 [plasma membrane]

Inferred To

Tnfsf12 [extracellular region] (Mus musculus)

Tnfsf12 [extracellular region] (Rattus norvegicus)

TNFSF12 [extracellular region] (Bos taurus)

TNFSF12 [extracellular region] (Sus scrofa)

tnfsf12 [extracellular region] (Xenopus tropicalis)

sTNFSF12 [extracellular region] (Canis familiaris)

sTNFSF12 [extracellular region] (Danio rerio)

Cross References

RefSeq

NP_003800.1, NP_742086.1

OpenTargets

ENSG00000239697

HPA

ENSG00000239697-TNFSF12

GeneCards

O43508

Ensembl

ENSP00000293825, ENST00000293825, ENSG00000239697

PRO

O43508

Pharos - Targets

O43508

Orphanet

22038

PDB

4HT1

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NP84 TNFRSF12A	1	TNFRSF12A [plasma membrane] (R-HSA-5675666)	0.558	2
UniProt:P06493 CDK1	11	CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) p-Y4-CDK1 [cytosol] (R-HSA-9836187) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14-CDK1 [cytosol] (R-HSA-170064) CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [cytosol] (R-HSA-170075) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [nucleoplasm] (R-HSA-170066)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P35638 DDIT3	1	DDIT3 [nucleoplasm] (R-HSA-381110)	0.556	3
UniProt:Q9UPY3 DICER1	1	DICER1 [cytosol] (R-HSA-203820)	0.543	3