Reactome | PTPLAD1 [endoplasmic reticulum membrane]

PTPLAD1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-5676074

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3, HACD3

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
18554506	Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis Ikeda, M, Kanao, Y, Yamanaka, M, Sakuraba, H, Igarashi, Y, Kihara, A, Mizutani, Y	FEBS Lett.	2008

External Reference Information

External Reference

UniProt:Q9P035 HACD3

Gene Names

HACD3, BIND1, PTPLAD1

Chain

chain:1-362

Reference Genes

BioGPS Gene:51495 HACD3

COSMIC (genes):HACD3 HACD3

CTD Gene:51495 HACD3

dbSNP Gene:51495 HACD3

ENSEMBL:ENSG00000074696 HACD3

HGNC:24175 HACD3

KEGG:hsa:51495 HACD3

Monarch:51495 HACD3

NCBI Gene:51495 HACD3

OMIM:615940 HACD3

UCSC:Q9P035 HACD3

Reference Transcript

RefSeq:NM_016395.2 HACD3

Other Identifiers

11715864_a_at

11746799_a_at

11746800_s_at

11757829_a_at

16802106

217777_PM_s_at

217777_s_at

222404_PM_x_at

222404_x_at

222405_3p_at

222405_PM_at

222405_at

234000_PM_s_at

234000_s_at

3598382

3598383

3598385

3598387

3598395

3598397

3598398

3598399

3598400

3598401

3598402

3598406

3598408

3598409

3598411

3598412

3598413

3598416

3598419

3598421

3598422

3598423

3598425

45284_at

51495

7984263

83275_at

87622_s_at

87625_r_at

92109_at

92111_g_at

A_14_P139294

A_23_P99927

A_33_P3365676

GE61680

GO:0003824

GO:0005096

GO:0005515

GO:0005783

GO:0005789

GO:0005925

GO:0006629

GO:0006633

GO:0007249

GO:0007254

GO:0007264

GO:0007266

GO:0016020

GO:0016601

GO:0016829

GO:0018812

GO:0019899

GO:0030148

GO:0030497

GO:0031965

GO:0042761

GO:0043226

GO:0045070

GO:0046726

GO:0098772

GO:0102158

GO:1902532

HMNXSV003043715

Hs.260622.0.S1_3p_a_at

Hs.260622.0.S3_3p_at

Hs.260622.0.S3_3p_s_at

ILMN_1658746

ILMN_1737398

ILMN_1743065

PH_hs_0026337

PH_hs_0036062

TC15000606.hg

g7705458_3p_a_at

Participates

as a candidate of

PTPLs [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

HACD3 [endoplasmic reticulum membrane] (Bos taurus)

HACD3 [endoplasmic reticulum membrane] (Canis familiaris)

HACD3 [endoplasmic reticulum membrane] (Gallus gallus)

HACD3 [endoplasmic reticulum membrane] (Sus scrofa)

PTPLAD1 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

PTPLAD1 [endoplasmic reticulum membrane] (Dictyostelium discoideum)

hacd3 [endoplasmic reticulum membrane] (Danio rerio)

hacd3 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Hacd2 [endoplasmic reticulum membrane] (Drosophila melanogaster)

Hacd3 [endoplasmic reticulum membrane] (Mus musculus)

Hacd3 [endoplasmic reticulum membrane] (Rattus norvegicus)

Cross References

ENSEMBL

ENST00000442729, ENSP00000261875, ENSP00000392491, ENST00000261875

OpenTargets

ENSG00000074696

HPA

ENSG00000074696-HACD3

PRO

Q9P035

Pharos - Targets

Q9P035

GlyGen

Q9P035

HMDB Protein

HMDBP09066

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.736	15
UniProt:P0DTC4 E	9	Ub-3xPalmC-E [virion membrane] (R-COV-9698416) Ub-3xPalmC-E [endocytic vesicle membrane] (R-COV-9698422) Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698420) Ub-3xPalmC-E [Golgi membrane] (R-COV-9694687) Ub-3xPalmC-E [endoplasmic reticulum membrane] (R-COV-9694465) Ub-3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694423) 3xPalmC-E [endoplasmic reticulum lumen] (R-COV-9694305) nascent E [endoplasmic reticulum lumen] (R-COV-9694312) N-glycan E [endoplasmic reticulum lumen] (R-COV-9694754)	0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2

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