Reactome | PTPLB [endoplasmic reticulum membrane]

PTPLB [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-5676075

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2, HACD2

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
18554506	Characterization of four mammalian 3-hydroxyacyl-CoA dehydratases involved in very long-chain fatty acid synthesis Ikeda, M, Kanao, Y, Yamanaka, M, Sakuraba, H, Igarashi, Y, Kihara, A, Mizutani, Y	FEBS Lett.	2008

External Reference Information

External Reference

UniProt:Q6Y1H2 HACD2

Gene Names

HACD2, PTPLB

Chain

initiator methionine:, chain:2-254

Reference Genes

BioGPS Gene:201562 HACD2

COSMIC (genes):HACD2 HACD2

CTD Gene:201562 HACD2

dbSNP Gene:201562 HACD2

ENSEMBL:ENSG00000206527 HACD2

HGNC:9640 HACD2

KEGG:hsa:201562 HACD2

Monarch:201562 HACD2

NCBI Gene:201562 HACD2

OMIM:615939 HACD2

UCSC:Q6Y1H2 HACD2

Reference Transcript

RefSeq:NM_198402.4 HACD2

Other Identifiers

11717333_at

11758773_at

11758774_at

16958236

201562

212640_PM_at

212640_at

227741_PM_at

227741_at

2692412

2692413

2692414

2692415

2692416

2692420

2692421

2692422

2692423

2692432

2692436

2692437

2692438

35342_at

76489_at

8090091

A_23_P155197

A_24_P135753

A_33_P3244194

GE54470

GO:0003824

GO:0005515

GO:0005783

GO:0005789

GO:0006629

GO:0006633

GO:0006790

GO:0016020

GO:0016829

GO:0018812

GO:0019899

GO:0030148

GO:0030497

GO:0035338

GO:0042761

GO:0043226

GO:0055086

GO:0102158

GO:1901135

HMNXSV003046803

HMNXSV003048929

Hs.127478.0.A1_3p_at

Hs.5957.0.S1_3p_at

ILMN_1690806

ILMN_2170353

PH_hs_0000603

TC03001711.hg

TC03001712.hg

TC03003054.hg

Participates

as a member of

PTPLs [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

PHS1 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

hpo-8 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

HACD2 [endoplasmic reticulum membrane] (Bos taurus)

HACD2 [endoplasmic reticulum membrane] (Canis familiaris)

HACD2 [endoplasmic reticulum membrane] (Sus scrofa)

hacd2 [endoplasmic reticulum membrane] (Danio rerio)

hacd2 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Hacd1 [endoplasmic reticulum membrane] (Drosophila melanogaster)

Hacd2 [endoplasmic reticulum membrane] (Mus musculus)

PTPLB [endoplasmic reticulum membrane] (Dictyostelium discoideum)

PTPLB [endoplasmic reticulum membrane] (Gallus gallus)

PTPLB [endoplasmic reticulum membrane] (Plasmodium falciparum)

PTPLB [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

Cross References

ENSEMBL

ENST00000383657, ENSP00000373153

OpenTargets

ENSG00000206527

HPA

ENSG00000206527-HACD2

PRO

Q6Y1H2

Pharos - Targets

Q6Y1H2

GlyGen

Q6Y1H2

HMDB Protein

HMDBP11774

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	3
UniProt:Q13651 IL10RA	3	p-Y446-IL10RA [plasma membrane] (R-HSA-6784810) p-Y496-IL10RA [plasma membrane] (R-HSA-6784793) IL10RA [plasma membrane] (R-HSA-449841)	0.556	3
UniProt:P51572 BCAP31	6	BCAP31 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985503) BCAP31 [endoplasmic reticulum membrane] (R-HSA-9714333) BCAP31(2-245) [endoplasmic reticulum membrane] (R-HSA-201587) BCAP31(165-237) [endoplasmic reticulum membrane] (R-HSA-351909) BCAP31(2-164) [endoplasmic reticulum membrane] (R-HSA-351826) BCAP31(238-246) [cytosol] (R-HSA-351912)	0.543	4
UniProt:P25103 TACR1	2	TACR1 [plasma membrane] (R-HSA-380103) TACR1 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869122)	0.527	2
UniProt:Q16581 C3AR1	3	C3AR1 [plasma membrane] (R-HSA-444727) C3AR1 [azurophil granule membrane] (R-HSA-6799517) C3AR1 [specific granule membrane] (R-HSA-6799516)	0.527	2
UniProt:P35414 APLNR	1	APLNR [plasma membrane] (R-HSA-374259)	0.527	2
UniProt:Q9H8X2 IPPK	2	IPPK [cytosol] (R-HSA-1604598) IPPK [nucleoplasm] (R-HSA-2023949)	0.527	2
UniProt:P25090 FPR2	4	FPR2 [plasma membrane] (R-HSA-416408) FPR2 [ficolin-1-rich granule membrane] (R-HSA-6803335) FPR2 [specific granule membrane] (R-HSA-6803319) FPR2 [tertiary granule membrane] (R-HSA-6803296)	0.527	2
UniProt:Q15758 SLC1A5	1	SLC1A5 [plasma membrane] (R-HSA-352376)	0.527	2
UniProt:Q9H2J7 SLC6A15	1	SLC6A15 [plasma membrane] (R-HSA-352060)	0.527	2

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