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WIPIs bind PI3P
Stable Identifier
R-HSA-5676229
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
phagophore assembly site membrane
ReviewStatus
5/5
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WIPIs bind PI3P (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
WD repeat domain phospoinositide-interacting protein 2 (WIPI2) was identified as the mammalian homologue of yeast Atg18 (Polson et al. 2010). Like the other WIPI proteins, it binds PI(3,5)P2 and is recruited to autophagosomal membranes, especially upon autophagy induction (Proikas-Cezanne et al. 2015). WIPI1, WIPI2 and WIPI4 all localize to the initiating autophagosome during autophagy (Proikas-Cezanne et al. 2007, Obara et al. 2008, Polson et al. 2010). WIPI2 has been found to specifically bind to ATG16L1, thereby recruiting the ATG12:ATG5:ATG16L1 complex that is required for LC3 lipidation (Dooley et al. 2014).
Literature References
PubMed ID
Title
Journal
Year
17618624
Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy
Nordheim, A
,
Berg, C
,
Ruckerbauer, S
,
Proikas-Cezanne, T
,
Stierhof, YD
FEBS Lett.
2007
Participants
Input
PI3P [phagophore assembly site membrane]
WIPI1,WIPI2,(WDR45,WDR45B) [cytosol]
(Homo sapiens)
Output
WIPI1,WIPI2,(WDR45,WDR45B):PI3P [phagophore assembly site membrane]
(Homo sapiens)
Participates
as an event of
Macroautophagy (Homo sapiens)
Orthologous Events
WIPIs bind PI3P (Bos taurus)
WIPIs bind PI3P (Caenorhabditis elegans)
WIPIs bind PI3P (Canis familiaris)
WIPIs bind PI3P (Danio rerio)
WIPIs bind PI3P (Dictyostelium discoideum)
WIPIs bind PI3P (Drosophila melanogaster)
WIPIs bind PI3P (Gallus gallus)
WIPIs bind PI3P (Mus musculus)
WIPIs bind PI3P (Rattus norvegicus)
WIPIs bind PI3P (Saccharomyces cerevisiae)
WIPIs bind PI3P (Schizosaccharomyces pombe)
WIPIs bind PI3P (Sus scrofa)
WIPIs bind PI3P (Xenopus tropicalis)
Authored
Jupe, S (2015-02-02)
Reviewed
Klionsky, DJ (2015-09-03)
Tooze, SA (2015-05-13)
Created
Jupe, S (2015-02-19)
© 2024
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