Reactome | ULK1 phosphorylates Beclin-1

ULK1 phosphorylates Beclin-1

Stable Identifier

R-HSA-5679205

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

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Following amino-acid starvation or mTOR inhibition, activated ULK1 phosphorylates BECN1 (Beclin-1) on Ser-15, thereby enhancing the activity of PIK3C3 (Vps34) in the Beclin-1 complex. This phosphorylation is required for full autophagic induction in mammals (Russell et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23685627	ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase Park, HW, Guan, KL, Yuan, H, Dillin, A, Tian, Y, Russell, RC, Kim, J, Neufeld, TP, Kim, H, Chang, YY	Nat. Cell Biol.	2013

Participants

Input

Output

Participates

as an event of

Macroautophagy (Homo sapiens)

Catalyst Activity

protein serine/threonine kinase activity of p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane]

Physical Entity

p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)

Activity

protein serine/threonine kinase activity (GO:0004674)

Orthologous Events

ULK1 phosphorylates Beclin-1 (Bos taurus)

ULK1 phosphorylates Beclin-1 (Caenorhabditis elegans)

ULK1 phosphorylates Beclin-1 (Canis familiaris)

ULK1 phosphorylates Beclin-1 (Danio rerio)

ULK1 phosphorylates Beclin-1 (Dictyostelium discoideum)

ULK1 phosphorylates Beclin-1 (Drosophila melanogaster)

ULK1 phosphorylates Beclin-1 (Gallus gallus)