Reactome | ULK complex translocates to the ER

ULK complex translocates to the ER

Stable Identifier

R-HSA-5679239

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

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The ULK complex is recruited to the membrane site of phagophore nucleation, which is likely to be a pre-existing ER structure containing the multi-membrane spanning protein vacuole membrane protein 1 (VMP1) (Wirth et al. 2013, Koyama-Honda et al. 2013). This may be mediated by the C-terminal early autophagy targeting/tethering (EAT) domain of ULK1, which appears to be essential for recruitment to the site of phagophore nucleation (Chan et al. 2009, Ragusa et al. 2012). The N-terminus of the ATG13 component of the ULK complex may also contribute to membrane association as it can interact with acidic phospholipids and is required for the translocation of ATG13 to omegasomes (Karanasios et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
23727157	Autophagosome formation--the role of ULK1 and Beclin1-PI3KC3 complexes in setting the stage Wirth, M, Joachim, J, Tooze, SA	Semin. Cancer Biol.	2013
23884233	Temporal analysis of recruitment of mammalian ATG proteins to the autophagosome formation site Koyama-Honda, I, Itakura, E, Fujiwara, TK, Mizushima, N	Autophagy	2013