MRN bound to shortened telomeres activates ATM

Stable Identifier
R-HSA-5682026
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MRN bound to shortened telomeres activates ATM
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MRN bound to shortened telomeres promotes dissociation of ATM dimers to ATM monomers which is accompanied by ATM autophosphorylation on serine residue S1981. Dissociation of ATM dimers requires the ATP-dependent DNA-helicase activity of the MRN subunit RAD50 (Lee and Paull 2005, Wu et al. 2007).

Literature References
PubMed ID Title Journal Year
15790808 ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

Paull, TT, Lee, JH

Science 2005
17694070 MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control

Xiao, S, Wu, Y, Zhu, XD

Nat. Struct. Mol. Biol. 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm]

Physical Entity
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
MRN bound to shortened telomeres activates ATM (Bos taurus)
MRN bound to shortened telomeres activates ATM (Canis familiaris)
MRN bound to shortened telomeres activates ATM (Danio rerio)
MRN bound to shortened telomeres activates ATM (Dictyostelium discoideum)
MRN bound to shortened telomeres activates ATM (Drosophila melanogaster)
MRN bound to shortened telomeres activates ATM (Gallus gallus)
MRN bound to shortened telomeres activates ATM (Mus musculus)
MRN bound to shortened telomeres activates ATM (Rattus norvegicus)
MRN bound to shortened telomeres activates ATM (Saccharomyces cerevisiae)
MRN bound to shortened telomeres activates ATM (Schizosaccharomyces pombe)
MRN bound to shortened telomeres activates ATM (Sus scrofa)
MRN bound to shortened telomeres activates ATM (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2015-03-05)
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