Reactome | PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer

PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer

Stable Identifier

R-HSA-5682101

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer

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ATP-binding cassette sub-family A member 1 (ABCA1) is a key mediator of cholesterol and phospholipid efflux to apolipoprotein particles. This efflux activity is regulated by protein kinase A (PKA) site-specific phosphorylation of ABCA1 at Ser-1042 and Ser-2054, located in the nucleotide binding domains of ABCA1 (See et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
12196520	Protein kinase A site-specific phosphorylation regulates ATP-binding cassette A1 (ABCA1)-mediated phospholipid efflux Wellington, CL, Zhang, LH, Huber, MT, Zhou, S, Rigot, V, Wang, M, Hayden, MR, James, ER, Silverston, A, Singaraja, RR, Tafuri, SR, Moran, J, Caday-Malcolm, RA, Chimini, G, Janoo, R, See, RH, Savill, JM	J. Biol. Chem.	2002