Reactome | UIMC1 [nucleoplasm]

UIMC1 [nucleoplasm]

Stable Identifier

R-HSA-5682574

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

BRCA1-A complex subunit RAP80, RAP80, Receptor-associated protein 80, RXRIP110, Retinoid X receptor-interacting protein 110, Ubiquitin interaction motif-containing protein 1

Locations in the PathwayBrowser for interactor UniProt:Q6UWZ7 ABRAXAS1

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External Reference Information

External Reference

UniProt:Q96RL1 UIMC1

Gene Names

UIMC1, RAP80, RXRIP110

Chain

chain:1-719

Reference Genes

BioGPS Gene:51720 UIMC1

COSMIC (genes):UIMC1 UIMC1

CTD Gene:51720 UIMC1

dbSNP Gene:51720 UIMC1

ENSEMBL:ENSG00000087206 UIMC1

HGNC:30298 UIMC1

KEGG:hsa:51720 UIMC1

Monarch:51720 UIMC1

NCBI Gene:51720 UIMC1

OMIM:609433 UIMC1

UCSC:Q96RL1 UIMC1

Reference Transcript

Participates

as an output of

as a component of

as an input of

UIMC1 and FAM175A bind DNA DSBs (Homo sapiens)

Inferred To

Ghost homologue of UIMC1 [nucleoplasm] (Danio rerio)

Uimc1 [nucleoplasm] (Mus musculus)

Uimc1 [nucleoplasm] (Rattus norvegicus)

UIMC1 [nucleoplasm] (Bos taurus)

UIMC1 [nucleoplasm] (Canis familiaris)

UIMC1 [nucleoplasm] (Gallus gallus)

UIMC1 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

XP_054208783.1, NP_057374.3, XP_005265993.1, XP_016865068.1, XP_005265987.1, XP_006714934.1, XP_054208784.1, NP_001186227.1, XP_016865067.1, XP_016865063.1, NP_001304890.1, NP_001186226.1

OpenTargets

ENSG00000087206

ENSEMBL

ENST00000377227, ENST00000506128, ENSP00000423717, ENST00000511320, ENSP00000421926, ENSG00000087206, ENST00000510698, ENSP00000366434, ENSP00000427480

HPA

ENSG00000087206-UIMC1

GeneCards

UIMC1

PRO

Q96RL1

Pharos - Targets

Q96RL1

PDB

2MKG, 2RR9, 2MKF, 2N9E

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.78	13
UniProt:Q6UWZ7 ABRAXAS1	1	p-S406-FAM175A [nucleoplasm] (R-HSA-5682575)	0.677	9
UniProt:O14641 DVL2	5	pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) DVL2 [cytosol] (R-HSA-201694) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) ub-DVL2 [cytosol] (R-HSA-4652689)	0.668	4
UniProt:Q9NWV8 BABAM1	2	BABAM1 [nucleoplasm] (R-HSA-5682582) BABAM1 [cytosol] (R-HSA-5691418)	0.527	4

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