PIAS4, an E3 SUMO ligase, is recruited to DNA double-strand breaks (DSBs) via an unknown mechanism that requires a DNA-binding SAP domain of PIAS4 (Galanty et al. 2009). HERC2, an E3 ubiquitin ligase and a PIAS4 target, is recruited to DNA DSBs probably through its interaction with ATM (Bekker-Jensen et al. 2010).
Jackson, SP, Polo, S, Coates, J, Miller, KM, Galanty, Y, Belotserkovskaya, R
Lukas, J, Gromova, I, Rendtlew Danielsen, J, Bartek, J, Nerstedt, A, Lukas, C, Fugger, K, Bekker-Jensen, S, Mailand, N
© 2023 Reactome