Reactome | ATM phosphorylates HERC2

ATM phosphorylates HERC2

Stable Identifier

R-HSA-5682598

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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ATM phosphorylates HERC2 on threonine residue T4827. This threonine residue may also be phosphorylated by ATR and DNA-PKcs (PRKDC) (Bekker-Jensen et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20023648	HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes Lukas, J, Gromova, I, Rendtlew Danielsen, J, Bartek, J, Nerstedt, A, Lukas, C, Fugger, K, Bekker-Jensen, S, Mailand, N	Nat. Cell Biol.	2010

Participants

Input

Output

Participates

as an event of

Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)

Catalyst Activity

protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm]

Physical Entity

DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] (Homo sapiens)

Activity

protein serine/threonine kinase activity (GO:0004674)

Orthologous Events

ATM phosphorylates HERC2 (Bos taurus)

ATM phosphorylates HERC2 (Canis familiaris)

ATM phosphorylates HERC2 (Drosophila melanogaster)

ATM phosphorylates HERC2 (Gallus gallus)

ATM phosphorylates HERC2 (Mus musculus)

ATM phosphorylates HERC2 (Rattus norvegicus)

ATM phosphorylates HERC2 (Saccharomyces cerevisiae)