HERC2 facilitates UBE2N:UBE2V2 binding to RNF8

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

HERC2 facilitates binding of the E2 ubiquitin conjugase dimer UBE2N:UBE2V2 (UBC13:MMS2) to RNF8 at DNA double strand breaks (DSBs) (Kolas et al. 2007, Bekker-Jensen et al. 2010, Campbell et al. 2012).

Literature References
PubMed ID Title Journal Year
18006705 Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

Kolas, NK, Chapman, JR, Nakada, S, Ylanko, J, Chahwan, R, Sweeney, FD, Panier, S, Mendez, M, Wildenhain, J, Thomson, TM, Pelletier, L, Jackson, SP, Durocher, D

Science 2007
20023648 HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

Bekker-Jensen, S, Rendtlew Danielsen, J, Fugger, K, Gromova, I, Nerstedt, A, Lukas, C, Bartek, J, Lukas, J, Mailand, N

Nat. Cell Biol. 2010
22589545 Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation

Campbell, SJ, Edwards, RA, Leung, CC, Neculai, D, Hodge, CD, Dhe-Paganon, S, Glover, JN

J. Biol. Chem. 2012
Orthologous Events
Cite Us!