K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]

Stable Identifier
R-HSA-5682847
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
K63PolyUb-K14,K16,p-S139-H2AFX, Ub,gamma-H2AX
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P16104 H2AX
Gene Names
H2AFX, H2AX
Chain
initiator methionine:1, chain:2-143
Reference Genes
BioGPS Gene:3014 H2AFX
COSMIC (genes):H2AFX H2AFX
CTD Gene:3014 H2AFX
dbSNP Gene:3014 H2AFX
ENSEMBL:ENSG00000188486 H2AFX
ENSEMBL:ENSG00000188486.4 H2AFX
HGNC:4739 H2AFX
KEGG Gene (Homo sapiens):3014 H2AFX
Monarch:3014 H2AFX
NCBI Gene:3014 H2AFX
OMIM:601772 H2AFX
UCSC:P16104 H2AFX
Reference Transcript
Other Identifiers
11754243_a_at
16745236
205436_PM_s_at
205436_s_at
212525_3p_s_at
212525_PM_s_at
212525_s_at
3014
3394184
3394185
3394186
3394187
3394188
3394189
3394190
40195_at
7952179
A_24_P38895
GE59719
GO:0000077
GO:0000228
GO:0000724
GO:0000781
GO:0000785
GO:0000786
GO:0000794
GO:0001673
GO:0001741
GO:0003677
GO:0003684
GO:0005198
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005657
GO:0005694
GO:0005813
GO:0005815
GO:0005856
GO:0006281
GO:0006302
GO:0006310
GO:0006325
GO:0006334
GO:0006974
GO:0007049
GO:0007283
GO:0010212
GO:0016607
GO:0019899
GO:0021987
GO:0022414
GO:0023052
GO:0030527
GO:0035861
GO:0042393
GO:0043226
GO:0043229
GO:0045739
GO:0046982
GO:0048856
GO:0051321
GO:0065003
GO:0070062
GO:0071480
GO:0090398
GO:0090734
HMNXSV003055476
Hs.147097.1.A1_3p_a_at
ILMN_1785756
ILMN_2200331
PH_hs_0008797
PH_hs_0040597
TC11002362.hg
X14850_at
g4504252_3p_a_at
Participates
as a component of
Other forms of this molecule
p-S140-H2AFX [nucleoplasm]
p-S140,Y143-H2AFX [nucleoplasm]
p-Y143-H2AFX [nucleoplasm]
H2AFX [nucleoplasm]
H2AFX [extracellular region]
Me2sR4-H2AFX [nucleoplasm]
Inferred To
phospho-H2ax [nucleoplasm] (Mus musculus)
phospho-H2ax [nucleoplasm] (Rattus norvegicus)
phospho-zgc:56685 [nucleoplasm] (Danio rerio)
phospho-K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (Canis familiaris)
phospho-K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (Danio rerio)
phospho-K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (Gallus gallus)
phospho-K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (Xenopus tropicalis)
phospho-h2az2 [nucleoplasm] (Xenopus tropicalis)
Homologues of K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (Danio rerio)
Homologues of K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (Xenopus tropicalis)
phospho-H2AX [nucleoplasm] (Sus scrofa)
Ghost homologue of K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (Bos taurus)
phospho-h2afx1 [nucleoplasm] (Danio rerio)
Modified Residues
Name
O-phospho-L-serine at 140
Coordinate
140
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
ubiquitinylated lysine (K63polyUb [nucleoplasm]) at 14
Coordinate
14
Modification
K63polyUb [nucleoplasm]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K63polyUb [nucleoplasm]) at 16
Coordinate
16
Modification
K63polyUb [nucleoplasm]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
HPA
GeneCards
Ensembl
PRO
Pharos - Targets
PDB
Interactors (35)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q14676 MDC1  6 0.965 21
 UniProt:O60934 NBN  3 0.859 14
 UniProt:P49959 MRE11  2 0.809 7
 UniProt:P62805 H4C1  17 0.802 5
 UniProt:P09874 PARP1  4 0.798 10
 UniProt:Q12888 TP53BP1  3 0.793 6
 UniProt:P38398 BRCA1  20 0.714 4
 UniProt:Q15554 TERF2  2 0.681 4
 UniProt:Q14191 WRN  2 0.667 6
 UniProt:Q16695 H3-4  3 0.641 12
 UniProt:P02545 LMNA  3 0.604 3
 UniProt:P63104 YWHAZ  2 0.577 6
 UniProt:P58876 H2BC5  9 0.564 2
 UniProt:Q6ZW49-1 PAXIP1      0.558 7
 UniProt:Q6P4T3 Q6P4T3      0.544 2
 UniProt:Q99986 VRK1  2 0.544 3
 UniProt:O15297 PPM1D  1 0.544 3
 UniProt:P51532 SMARCA4  1 0.537 9
 UniProt:Q08945 SSRP1  1 0.527 2
 UniProt:P55209 NP1L1      0.527 2
 UniProt:Q12905 ILF2  5 0.527 2
 UniProt:Q9Y5B9 SUPT16H  1 0.527 2
 UniProt:O94880 PHF14      0.527 2
 UniProt:P46783 RPS10  2 0.527 2
 UniProt:O15355 PPM1G      0.527 2
 UniProt:Q92878 RAD50  1 0.527 3
 UniProt:Q8N108 MIER1      0.527 2
 UniProt:P61769-PRO_0000018779 B2M      0.524 5
 UniProt:P45983 MAPK8  3 0.524 3
 UniProt:P46933-1 APBB1      0.524 2
 UniProt:P17693 HLA-G  7 0.524 5
 UniProt:Q13315 ATM  5 0.491 2
 UniProt:Q9NX02 NALP2      0.463 3
 IntAct:EBI-1265559 MYC      0.462 2
 IntAct:EBI-5276484 ACTB      0.462 2
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