WHSC1 dimethylates histone H4 on lysine K21 at DSBs

Stable Identifier
R-HSA-5682965
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
WHSC1 (MMSET) histone methyltransferase dimethylates histone H4 (HIST1H4A) on lysine residue K21 (commonly labeled in literature as K20), locally increasing the concentration of the H4K20Me2 mark. H4K20Me2 (Me2-K21-HIST1H4A) serves as a binding site for TP53BP1 (53BP1). The recruitment of WHSC1 to DNA double-strand breaks (DSBs) is independent of RNF8 and RNF168, but the catalytic activity of all three proteins is necessary for binding and accumulation of TP53BP1 at DSBs (Pei et al. 2011).
Literature References
PubMed ID Title Journal Year
21293379 MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

You, Z, Lou, Z, Chesi, M, Pei, H, Bergsagel, PL, Luo, K, Wang, L, Qin, Y, Zhang, L, Fei, F

Nature 2011
Participants
Participates
Catalyst Activity

histone methyltransferase activity (H4-K20 specific) of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
Cite Us!