Reactome | ATM phosphorylates WHSC1

ATM phosphorylates WHSC1

Stable Identifier

R-HSA-5682983

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Activated ATM phosphorylates WHSC1 (MMSET) on serine residue S102 (Matsuoka et al. 2007). The BRCT domain of MDC1 binds phosphorylated WHSC1, which is necessary for retention of WHSC1 at DNA double-strand break (DSB) sites (Pei et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
17525332	ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage Gygi, SP, Lerenthal, Y, Hurov, KE, Bakalarski, CE, Shiloh, Y, Smogorzewska, A, Ballif, BA, Zhao, Z, Elledge, SJ, Matsuoka, S, Luo, J, McDonald, ER, Solimini, N	Science	2007
21293379	MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites You, Z, Lou, Z, Chesi, M, Pei, H, Bergsagel, PL, Luo, K, Wang, L, Qin, Y, Zhang, L, Fei, F	Nature	2011