Reactome | BRCA1-A Complex [nucleoplasm]

BRCA1-A Complex [nucleoplasm]

Stable Identifier

R-HSA-5683386

Type

Complex

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

BRCA1:BARD1:BRCC3:BRE:BABAM1:UIMC1:p-S406-FAM175A

Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - DNA Double Strand Break Response (Homo sapiens)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
      - Formation of BRCA1-A complex at DNA DSBs (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] (Homo sapiens)
        
        BRCA1-A Complex [nucleoplasm] (Homo sapiens)
      - Phosphorylation of BRCA1-A complex at multiple sites by ATM (Homo sapiens)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] (Homo sapiens)
        
        BRCA1-A Complex [nucleoplasm] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
17525340	Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response Elledge, SJ, Matsuoka, S, Gygi, SP, Wang, B, Smogorzewska, A, Zhang, D, Ballif, BA	Science	2007

Participants

components

Participates

as a component of

Inferred To

BRCA1-A Complex [nucleoplasm] (Bos taurus)

BRCA1-A Complex [nucleoplasm] (Canis familiaris)

BRCA1-A Complex [nucleoplasm] (Gallus gallus)

BRCA1-A Complex [nucleoplasm] (Mus musculus)

BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)

BRCA1-A Complex [nucleoplasm] (Sus scrofa)

BRCA1-A Complex [nucleoplasm] (Xenopus tropicalis)

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