Reactome | GABARAPL2 [autophagosome membrane]

GABARAPL2 [autophagosome membrane]

Stable Identifier

R-HSA-5683633

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

autophagosome membrane

Synonyms

Gamma-aminobutyric acid receptor-associated protein-like 2, GBRL2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P60520 GABARAPL2

Gene Names

GABARAPL2, FLC3A, GEF2

Chain

chain:1-116, propeptide:-

Reference Genes

BioGPS Gene:11345 GABARAPL2

COSMIC (genes):GABARAPL2 GABARAPL2

CTD Gene:11345 GABARAPL2

dbSNP Gene:11345 GABARAPL2

ENSEMBL:ENSG00000034713 GABARAPL2

ENSEMBL_homo_sapiens_GENE:ENSG00000034713.8 GABARAPL2

HGNC:13291 GABARAPL2

KEGG Gene (Homo sapiens):11345 GABARAPL2

Monarch:11345 GABARAPL2

NCBI Gene:11345 GABARAPL2

OMIM:607452 GABARAPL2

UCSC:P60520 GABARAPL2

Reference Transcript

RefSeq:NM_007285.6 GABARAPL2

Other Identifiers

11345

11728661_a_at

11728662_s_at

11747514_a_at

11754495_x_at

16821076

209046_PM_s_at

209046_s_at

35767_at

3669060

3669061

3669064

3669067

3669072

3669073

7997272

A_23_P118313

A_24_P356338

GE61629

GO:0000045

GO:0000139

GO:0000149

GO:0000421

GO:0005515

GO:0005737

GO:0005773

GO:0005776

GO:0005783

GO:0005789

GO:0005794

GO:0005829

GO:0006891

GO:0006914

GO:0006995

GO:0008017

GO:0008092

GO:0008289

GO:0008429

GO:0015031

GO:0016020

GO:0016192

GO:0016236

GO:0030163

GO:0031410

GO:0031625

GO:0032781

GO:0043226

GO:0048487

GO:0050811

GO:0051117

GO:0070972

GO:1901799

HMNXSV003049457

ILMN_1796458

ILMN_2046315

PH_hs_0027060

TC16000620.hg

g12641848_3p_s_at

Participates

as a member of

Other forms of this molecule

GABARAPL2(1-117) [cytosol]

GABARAPL2 [cytosol]

Inferred To

GABARAPL2 [autophagosome membrane] (Bos taurus)

GABARAPL2 [autophagosome membrane] (Caenorhabditis elegans)

GABARAPL2 [autophagosome membrane] (Canis familiaris)

GABARAPL2 [autophagosome membrane] (Gallus gallus)

GABARAPL2 [autophagosome membrane] (Sus scrofa)

Gabarapl2 [autophagosome membrane] (Mus musculus)

Gabarapl2 [autophagosome membrane] (Rattus norvegicus)

gabarapl2 [autophagosome membrane] (Danio rerio)

gabarapl2 [autophagosome membrane] (Xenopus tropicalis)

GABARAP [autophagosome membrane] (Plasmodium falciparum)

atg8 [autophagosome membrane] (Dictyostelium discoideum)

atg8 [autophagosome membrane] (Schizosaccharomyces pombe)

ATG8 [autophagosome membrane] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_009216.1

OpenTargets

ENSG00000034713

HPA

ENSG00000034713-GABARAPL2

GeneCards

P60520

Ensembl

ENST00000037243, ENSG00000034713, ENSP00000037243

PRO

P60520

Pharos - Targets

P60520

HMDB Protein

HMDBP10646

PDB

6H8C, 7YO8, 7LK3, 4CO7

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13501 SQSTM1	7	SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.97	25
UniProt:Q9NT62 ATG3	8	ATG3 [cytosol] (R-HSA-5671860) CysO264-ATG3-MAP1LC3A [cytosol] (R-HSA-9819371) CysO264-ATG3-GABARAP [cytosol] (R-HSA-9819379) CysO264-ATG3-GABARAPL3 [cytosol] (R-HSA-5683569) CysO264-ATG3-MAP1LC3B [cytosol] (R-HSA-9819365) CysO264-ATG3-GABARAPL1 [cytosol] (R-HSA-9819381) CysO264-ATG3-MAP1LC3C [cytosol] (R-HSA-9819377) CysO264-ATG3-GABARAPL2 [cytosol] (R-HSA-9819376)	0.85	8
UniProt:Q9UH92 MLX	1	MLX [nucleoplasm] (R-HSA-163695)	0.742	5
UniProt:Q3MII6 TBC1D25	1	TBC1D25 [autophagosome] (R-HSA-8854607)	0.742	5
UniProt:Q14596 NBR1	2	NBR1 [peroxisomal membrane] (R-HSA-9665177) NBR1 [cytosol] (R-HSA-9665180)	0.725	11
UniProt:O00410 IPO5	1	IPO5 [nucleoplasm] (R-HSA-192675)	0.688	6
UniProt:O75385 ULK1	7	ULK1 [recycling endosome] (R-HSA-8854761) p-S758-ULK1 [cytosol] (R-HSA-5672131) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) ULK1 [cytosol] (R-HSA-1632847) ULK1 [mitochondrial outer membrane] (R-HSA-8948145)	0.681	4
UniProt:Q8IVP5 FUNDC1	4	p-S17-FUNDC1 [mitochondrial outer membrane] (R-HSA-8948140) p-S13,Y18-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934915) FUNDC1 [mitochondrial outer membrane] (R-HSA-8934922) p-S13-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934910)	0.666	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.635	3
UniProt:Q92945 KHSRP	4	p-S193-KHSRP [nucleoplasm] (R-HSA-450452) p-T692-KHSRP [cytosol] (R-HSA-451177) p-S193-KHSRP [cytosol] (R-HSA-450505) KSRP [cytosol] (R-HSA-450485)	0.564	2
UniProt:P22061 PCMT1	1	PCMT1 [cytosol] (R-HSA-5676580)	0.564	2
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.564	2
UniProt:O60238 BNIP3L	1	BNIP3L [mitochondrial outer membrane] (R-HSA-6798001)	0.556	3
UniProt:Q9NV35 NUDT15	1	NUDT15 [cytosol] (R-HSA-2394014)	0.556	3
UniProt:Q8N6T3 ARFGAP1	1	ARFGAP1 [cytosol] (R-HSA-200464)	0.556	3
UniProt:Q96A56 TP53INP1	1	TP53INP1 [nucleoplasm] (R-HSA-3215226)	0.556	6
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.547	2
UniProt:Q13685 AAMP	1	AAMP [cytosol] (R-HSA-9674636)	0.547	2
UniProt:P15880 RPS2	3	RPS2 [nucleoplasm] (R-HSA-6790655) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [cytosol] (R-HSA-72347)	0.547	2
UniProt:Q13188 STK3	4	p-T180-STK3(1-322) [cytosol] (R-HSA-2028696) STK3(323-491) [cytosol] (R-HSA-2028684) STK3(1-491) [cytosol] (R-HSA-2028280) p-T180-STK3(1-491) [cytosol] (R-HSA-2028274)	0.544	2
UniProt:Q8TC07 TBC1D15	1	TBC1D15 [cytosol] (R-HSA-8854150)	0.544	2
UniProt:Q13043 STK4	4	STK4(1-487) [cytosol] (R-HSA-201627) p-T183-STK4(1-326) [cytosol] (R-HSA-2028682) p-T183-STK4(1-487) [cytosol] (R-HSA-2028258) STK4(327-487) [cytosol] (R-HSA-2028668)	0.544	2
UniProt:Q9Z2F7	1	Bnip3l [mitochondrial outer membrane] (R-MMU-6798001)	0.544	2
UniProt:P46934 NEDD4	1	NEDD4 [cytosol] (R-HSA-975992)	0.525	6
UniProt:Q676U5 ATG16L1	1	ATG16L1 [cytosol] (R-HSA-5671734)	0.525	2
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [cytosol] (R-HSA-5205651)	0.483	2

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