WICH phosphorylates H2AFX on Y142

Stable Identifier
R-HSA-5683930
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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WICH phosphorylates H2AFX on Y142
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Under basal conditions, histone H2AFX (H2AX) is phosphorylated on tyrosine residue Y142 by the WICH complex composed of BAZ1B (WSTF) and SMARCA5 (SNF2H) (Xiao et al. 2009).
Literature References
PubMed ID Title Journal Year
19092802 WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity

Xiao, A, Li, H, Shechter, D, Ahn, SH, Fabrizio, LA, Erdjument-Bromage, H, Ishibe-Murakami, S, Wang, B, Tempst, P, Hofmann, K, Patel, DJ, Elledge, SJ, Allis, CD

Nature 2009
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of WICH [nucleoplasm]

Physical Entity
WICH [nucleoplasm] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
WICH phosphorylates H2AFX on Y142 (Bos taurus)
WICH phosphorylates H2AFX on Y142 (Canis familiaris)
WICH phosphorylates H2AFX on Y142 (Danio rerio)
WICH phosphorylates H2AFX on Y142 (Gallus gallus)
WICH phosphorylates H2AFX on Y142 (Mus musculus)
WICH phosphorylates H2AFX on Y142 (Rattus norvegicus)
WICH phosphorylates H2AFX on Y142 (Sus scrofa)
Authored
Orlic-Milacic, M  (2015-05-12)
Reviewed
Borowiec, JA  (2015-06-12)
Created
Orlic-Milacic, M  (2015-03-17)
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