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p-Y143-H2AFX [nucleoplasm]
Stable Identifier
R-HSA-5683942
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-Y142-H2AFX
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Homo sapiens)
DNA DSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-Y143-H2AFX [nucleoplasm] (Homo sapiens)
ATM recognizes H2AFX-Nucleosomes (Homo sapiens)
DNA DSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-Y143-H2AFX [nucleoplasm] (Homo sapiens)
p-Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-Y143-H2AFX [nucleoplasm] (Homo sapiens)
WICH phosphorylates H2AFX on Y142 (Homo sapiens)
p-Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
p-Y143-H2AFX [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16104 H2AFX
Gene Names
H2AFX, H2AX
Chain
initiator methionine:, chain:2-143
Reference Genes
BioGPS Gene:3014 H2AFX
COSMIC (genes):H2AFX H2AFX
CTD Gene:3014 H2AFX
dbSNP Gene:3014 H2AFX
ENSEMBL:ENSG00000188486 H2AFX
ENSEMBL_homo_sapiens_GENE:ENSG00000188486.4 H2AFX
HGNC:4739 H2AFX
KEGG Gene (Homo sapiens):3014 H2AFX
Monarch:3014 H2AFX
NCBI Gene:3014 H2AFX
OMIM:601772 H2AFX
UCSC:P16104 H2AFX
Reference Transcript
RefSeq:NM_002105.2 H2AFX
Other Identifiers
11754243_a_at
16745236
205436_PM_s_at
205436_s_at
212525_3p_s_at
212525_PM_s_at
212525_s_at
3014
3394184
3394185
3394186
3394187
3394188
3394189
3394190
40195_at
7952179
A_24_P38895
GE59719
GO:0000077
GO:0000228
GO:0000724
GO:0000781
GO:0000785
GO:0000786
GO:0000794
GO:0001673
GO:0001741
GO:0003677
GO:0003684
GO:0005198
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005657
GO:0005694
GO:0005813
GO:0005815
GO:0005856
GO:0006281
GO:0006302
GO:0006310
GO:0006325
GO:0006334
GO:0006974
GO:0007049
GO:0007283
GO:0010212
GO:0016607
GO:0019899
GO:0021987
GO:0022414
GO:0023052
GO:0030527
GO:0035861
GO:0042393
GO:0043226
GO:0043229
GO:0045739
GO:0046982
GO:0048856
GO:0051321
GO:0065003
GO:0070062
GO:0071480
GO:0090398
GO:0090734
HMNXSV003055476
Hs.147097.1.A1_3p_a_at
ILMN_1785756
ILMN_2200331
PH_hs_0008797
PH_hs_0040597
TC11002362.hg
X14850_at
g4504252_3p_a_at
Participates
as a component of
p-Y142-H2AFX-Nucleosome [nucleoplasm] (Homo sapiens)
Other forms of this molecule
Me2sR4-H2AFX [nucleoplasm]
H2AFX [nucleoplasm]
p-S140,Y143-H2AFX [nucleoplasm]
p-S140-H2AFX [nucleoplasm]
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
H2AFX [extracellular region]
Inferred To
phospho-hta1 [nucleoplasm]
(Schizosaccharomyces pombe)
phospho-HTA2 [nucleoplasm]
(Saccharomyces cerevisiae)
phospho-LOC100485548 [nucleoplasm]
(Xenopus tropicalis)
phospho-H2AX [nucleoplasm]
(Canis familiaris)
phospho-H2AX [nucleoplasm]
(Dictyostelium discoideum)
phospho-H2AX [nucleoplasm]
(Sus scrofa)
Ghost homologue of p-Y143-H2AFX [nucleoplasm]
(Bos taurus)
phospho-LOC116411633 [nucleoplasm]
(Xenopus tropicalis)
phospho-LOC100487632 [nucleoplasm]
(Xenopus tropicalis)
phospho-h2ac16 [nucleoplasm]
(Xenopus tropicalis)
phospho-hta2 [nucleoplasm]
(Schizosaccharomyces pombe)
phospho-H2Av2 [nucleoplasm]
(Dictyostelium discoideum)
phospho-LOC100859381 [nucleoplasm]
(Gallus gallus)
phospho-LOC101732059 [nucleoplasm]
(Xenopus tropicalis)
phospho-h2afx1 [nucleoplasm]
(Danio rerio)
phospho-His2A:CG33859 [nucleoplasm]
(Drosophila melanogaster)
phospho-p-Y143-H2AFX [nucleoplasm]
(Gallus gallus)
phospho-p-Y143-H2AFX [nucleoplasm]
(Plasmodium falciparum)
phospho-zgc:56685 [nucleoplasm]
(Danio rerio)
Homologues of p-Y143-H2AFX [nucleoplasm]
(Danio rerio)
Homologues of p-Y143-H2AFX [nucleoplasm]
(Dictyostelium discoideum)
Homologues of p-Y143-H2AFX [nucleoplasm]
(Drosophila melanogaster)
Homologues of p-Y143-H2AFX [nucleoplasm]
(Gallus gallus)
Homologues of p-Y143-H2AFX [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of p-Y143-H2AFX [nucleoplasm]
(Schizosaccharomyces pombe)
Homologues of p-Y143-H2AFX [nucleoplasm]
(Xenopus tropicalis)
phospho-LOC100487067 [nucleoplasm]
(Xenopus tropicalis)
phospho-His2A:CG33862 [nucleoplasm]
(Drosophila melanogaster)
phospho-H2AFX [nucleoplasm]
(Gallus gallus)
phospho-HTA1 [nucleoplasm]
(Saccharomyces cerevisiae)
phospho-H2ax [nucleoplasm]
(Mus musculus)
phospho-H2ax [nucleoplasm]
(Rattus norvegicus)
phospho-H2Av3 [nucleoplasm]
(Dictyostelium discoideum)
phospho-LOC116407737 [nucleoplasm]
(Xenopus tropicalis)
phospho-H2Av1 [nucleoplasm]
(Dictyostelium discoideum)
Modified Residues
Name
O4'-phospho-L-tyrosine at 143
Coordinate
143
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_002096.1
HPA
ENSG00000188486-H2AX
GeneCards
P16104
Ensembl
ENSP00000364310
,
ENST00000530167
,
ENSP00000434024
,
ENSG00000188486
,
ENST00000375167
PRO
P16104
Pharos - Targets
P16104
PDB
2D31
,
2DYP
,
7YQK
,
6K1J
,
6K1K
,
3SHV
,
2AZM
,
3SQD
,
3U3Z
,
6ZWK
,
3SZM
,
1YDP
,
6K1I
Interactors (34)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14676 MDC1
6
monoSUMO1-K1840-MDC1 [nucleoplasm]
(R-HSA-4570546)
polySUMO2,3-K1840-MDC1 [nucleoplasm]
(R-HSA-4570473)
K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm]
(R-HSA-5684074)
SUMO2-K1840,p-5T-MDC1 [nucleoplasm]
(R-HSA-5684061)
p-5T-MDC1 [nucleoplasm]
(R-HSA-75236)
MDC1 [nucleoplasm]
(R-HSA-75231)
0.965
21
UniProt:O60934 NBN
3
p-S343-NBN [nucleoplasm]
(R-HSA-75237)
NBN [cytosol]
(R-HSA-5684005)
NBN [nucleoplasm]
(R-HSA-75163)
0.859
14
UniProt:P49959 MRE11
2
MRE11A [nucleoplasm]
(R-HSA-59544)
MRE11A [cytosol]
(R-HSA-3204309)
0.809
7
UniProt:P62805 H4C1
17
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
HIST1H4A [extracellular region]
(R-HSA-977569)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
HIST1H4 [nucleoplasm]
(R-HSA-181902)
0.802
5
UniProt:P09874 PARP1
4
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551617)
monoSUMO1-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551686)
PAR-PARP1 [nucleoplasm]
(R-HSA-5651713)
PARP1 [nucleoplasm]
(R-HSA-201568)
0.798
10
UniProt:Q12888 TP53BP1
3
monoSUMO1-K-TP53BP1 [nucleoplasm]
(R-HSA-2997591)
p-S25,S1778-TP53BP1 [nucleoplasm]
(R-HSA-5683418)
TP53BP1 [nucleoplasm]
(R-HSA-61175)
0.793
6
UniProt:P38398 BRCA1
20
polySUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
monoSUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
BRCA1 M1411T [nucleoplasm]
(R-HSA-9702140)
BRCA1 M1400V [nucleoplasm]
(R-HSA-9701202)
BRCA1 L1407P [nucleoplasm]
(R-HSA-9702135)
BRCA1 Y777* [nucleoplasm]
(R-HSA-9702765)
BRCA1 S1009* [nucleoplasm]
(R-HSA-9702755)
BRCA1 P724Lfs*12 [nucleoplasm]
(R-HSA-9703778)
BRCA1 S451* [nucleoplasm]
(R-HSA-9702754)
BRCA1 S864* [nucleoplasm]
(R-HSA-9702752)
BRCA1 P897Kfs*5 [nucleoplasm]
(R-HSA-9703782)
BRCA1 N555Kfs*17 [nucleoplasm]
(R-HSA-9703781)
BRCA1 Y1127Sfs*6 [nucleoplasm]
(R-HSA-9703780)
BRCA1 S886Cfs*16 [nucleoplasm]
(R-HSA-9703802)
BRCA1 V83Cfs*2 [nucleoplasm]
(R-HSA-9703800)
BRCA1 T464Pfs*11 [nucleoplasm]
(R-HSA-9703807)
BRCA1 G813Dfs*2 [nucleoplasm]
(R-HSA-9703549)
BRCA1 V340Gfs*6 [nucleoplasm]
(R-HSA-9703804)
BRCA1 Y655* [nucleoplasm]
(R-HSA-9702769)
BRCA1 W372* [nucleoplasm]
(R-HSA-9702768)
0.714
4
UniProt:Q15554 TERF2
2
TERF2 [nucleoplasm]
(R-HSA-174895)
p-S365-TERF2 [nucleoplasm]
(R-HSA-9686530)
0.681
4
UniProt:Q14191 WRN
2
WRN [nucleoplasm]
(R-HSA-67387)
monoSUMO1-K356,K496,K898-WRN [nucleoplasm]
(R-HSA-4568904)
0.667
6
UniProt:Q16695 H3-4
3
HIST3H3 [nucleoplasm]
(R-HSA-181914)
Me3K5-HIST3H3 [nucleoplasm]
(R-HSA-2245188)
Me2K5-HIST3H3 [nucleoplasm]
(R-HSA-2245186)
0.641
12
UniProt:P02545 LMNA
3
LMNA(1-646) [nuclear envelope]
(R-HSA-535479)
LMNA(1-567)-RAF1(279-648) fusion [cytosol]
(R-HSA-6802399)
LMNA(1-567)-p-RAF1(279-648) fusion [cytosol]
(R-HSA-6802537)
0.604
3
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.577
6
UniProt:P58876 H2BC5
9
Ub-HIST1H2BD [nucleoplasm]
(R-HSA-6782546)
AcK-HIST1H2BD [nucleoplasm]
(R-HSA-4549255)
HIST1H2BD [extracellular region]
(R-HSA-977561)
AcK16-HIST1H2BD [nucleoplasm]
(R-HSA-4568633)
AcK6-HIST1H2BD [nucleoplasm]
(R-HSA-4568642)
AcK21-HIST1H2BD [nucleoplasm]
(R-HSA-4568627)
AcK13-HIST1H2BD [nucleoplasm]
(R-HSA-4568645)
Ub-121-HIST1H2BD [nucleoplasm]
(R-HSA-3364025)
HIST1H2BD [nucleoplasm]
(R-HSA-181912)
0.564
2
UniProt:Q6ZW49-1 PAXIP1
0.558
7
UniProt:Q6P4T3 Q6P4T3
0.544
2
UniProt:Q99986 VRK1
2
VRK1 [cytosol]
(R-HSA-2995381)
VRK1 [nucleoplasm]
(R-HSA-2528998)
0.544
3
UniProt:O15297 PPM1D
1
PPM1D [nucleoplasm]
(R-HSA-2562518)
0.544
3
UniProt:P51532 SMARCA4
1
SMARCA4 [nucleoplasm]
(R-HSA-201686)
0.537
9
UniProt:P55209 NP1L1
0.527
2
UniProt:O94880 PHF14
0.527
2
UniProt:P46783 RPS10
2
RPS10 [nucleoplasm]
(R-HSA-6798733)
RPS10 [cytosol]
(R-HSA-72325)
0.527
2
UniProt:O15355 PPM1G
0.527
2
UniProt:Q92878 RAD50
1
RAD50 [nucleoplasm]
(R-HSA-75160)
0.527
3
UniProt:Q8N108 MIER1
0.527
2
UniProt:Q9Y5B9 SUPT16H
1
SUPT16H [nucleoplasm]
(R-HSA-112415)
0.527
2
UniProt:Q12905 ILF2
5
ILF2 [ficolin-1-rich granule lumen]
(R-HSA-6801001)
ILF2 [extracellular region]
(R-HSA-6799684)
ILF2 [specific granule lumen]
(R-HSA-6799611)
ILF2 [tertiary granule lumen]
(R-HSA-6800995)
ILF2 [cytosol]
(R-HSA-9836392)
0.527
2
UniProt:Q08945 SSRP1
1
SSRP1 [nucleoplasm]
(R-HSA-65105)
0.527
2
UniProt:P61769-PRO_0000018779 B2M
0.524
5
UniProt:P46933-1 APBB1
0.524
2
UniProt:P45983 MAPK8
3
MAPK8 [cytosol]
(R-HSA-168141)
p-T,Y-MAPK8 [cytosol]
(R-HSA-194371)
p-T,Y-MAPK8 [nucleoplasm]
(R-HSA-216349)
0.524
3
UniProt:Q13315 ATM
5
Ac-K3016-ATM [nucleoplasm]
(R-HSA-5682043)
ATM [nucleoplasm]
(R-HSA-69484)
p-S1981,Ac-K3016-ATM [nucleoplasm]
(R-HSA-5693527)
ATM [peroxisomal matrix]
(R-HSA-9665169)
ATM [cytosol]
(R-HSA-9665171)
0.491
2
UniProt:Q9NX02 NALP2
0.463
3
IntAct:EBI-1265559 MYC
0.462
2
IntAct:EBI-5276484 ACTB
0.462
2
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